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EC number: 451-690-9 | CAS number: 86273-46-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 17 February 2009 to 5 March 2009
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The non-GLP study meets generally accepted scientific standards, is well documented and acceptable for assessment.
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- GLP compliance:
- no
- Remarks:
- In-house study not conducted to GLP
- Radiolabelling:
- no
- Analytical monitoring:
- yes
- Buffers:
- Test System:
- A sterile buffer pH4: Potassium hydrogen phthalate aqueous solution
- A sterile buffer pH7: Potassium dihydrogen phosphate aqueous solution
- A sterile buffer PH9: Sodium tetraborate aqueous solution
Reagents:
- pH 4 buffer solution: Wako Pure Chemical Industries, Inc. Buffer Solution Standard (#028-03185), Japan
- pH 7 buffer solution: Wako Pure Chemical Industries, Inc. Buffer Solution Standard (#025-03195), Japan
- pH 9 buffer solution: Wako Pure Chemical Industries, Inc. Buffer Solution Standard (#028-03205), Japan
- Ethylene glycol: >99%, Wako Pure Chemical Industries, Inc., Japan - Details on test conditions:
- TEST SYSTEM
- Lighting: No
- Measures taken to avoid photolytic effects: Test conducted in darkness - Duration:
- 2 h
- pH:
- 4
- Temp.:
- 30 °C
- Initial conc. measured:
- 876.9 mg/L
- Duration:
- 1 h
- pH:
- 4
- Temp.:
- 40 °C
- Initial conc. measured:
- 874.8 mg/L
- Duration:
- 132 h
- pH:
- 7
- Temp.:
- 30 °C
- Initial conc. measured:
- 971 mg/L
- Duration:
- 72 h
- pH:
- 7
- Temp.:
- 40 °C
- Initial conc. measured:
- 928 mg/L
- Duration:
- 40 h
- pH:
- 9
- Temp.:
- 30 °C
- Initial conc. measured:
- 952.9 mg/L
- Duration:
- 18 h
- pH:
- 9
- Temp.:
- 40 °C
- Initial conc. measured:
- 916.7 mg/L
- Number of replicates:
- 1
- Positive controls:
- no
- Negative controls:
- no
- Statistical methods:
- The logarithms of all relative concentrations were plotted against time and a linear regression program (least-squares method) was used to calculate the regression line.
- Preliminary study:
- For testing of pseudo-first order kinetics (Test 1 according to EEC guideline C.7) at pH7 and pH9, the logarithms of the relative concentrations between 80 % and 30 % (i.e. between 20 % and 70 % hydrolysis) were plotted against time. Because at both pHs linear relationships were found, the reactions were considered to be (pseudo)-first order. Hence, the half-life times at 25 °C were estimated in a subsequent test.
- Test performance:
- The coefficients of determination (R²) were between 0.9995 and 0.9841, which confirmed the satisfying linearity of the results.
- Transformation products:
- not measured
- pH:
- 4
- Temp.:
- 40 °C
- Hydrolysis rate constant:
- 1.174 h-1
- DT50:
- 0.59 h
- pH:
- 4
- Temp.:
- 30 °C
- Hydrolysis rate constant:
- 0.563 h-1
- DT50:
- 1.231 h
- pH:
- 4
- Temp.:
- 25 °C
- Hydrolysis rate constant:
- 0.382 h-1
- DT50:
- 1.81 h
- Remarks on result:
- other: the rate constant (and the corresponding half-life time) at 25 °C was calculated using the Arrhenius equation
- pH:
- 7
- Temp.:
- 40 °C
- Hydrolysis rate constant:
- 0.016 h-1
- DT50:
- 42.2 h
- pH:
- 7
- Temp.:
- 30 °C
- Hydrolysis rate constant:
- 0.006 h-1
- DT50:
- 116.92 h
- pH:
- 7
- Temp.:
- 25 °C
- Hydrolysis rate constant:
- 0.003 h-1
- DT50:
- 200.1 h
- Remarks on result:
- other: the rate constant (and the corresponding half-life time) at 25 °C was calculated using the Arrhenius equation
- pH:
- 9
- Temp.:
- 40 °C
- Hydrolysis rate constant:
- 0.05 h-1
- DT50:
- 14 h
- pH:
- 9
- Temp.:
- 30 °C
- Hydrolysis rate constant:
- 0.018 h-1
- DT50:
- 39.02 h
- pH:
- 9
- Temp.:
- 25 °C
- Hydrolysis rate constant:
- 0.01 h-1
- DT50:
- 66.88 h
- Remarks on result:
- other: the rate constant (and the corresponding half-life time) at 25 °C was calculated using the Arrhenius equation
- Conclusions:
- The hydrolysis of the test substance as a function of pH was assessed according to EU Method C7. The test substance was determined to be hydrolytically unstable (half-life time at 25 °C < 1 day) in aqueous solutions buffered at pH 4. The half-life time of the test substance at 25 °C was 1.81 h in aqueous solutions buffered at pH 4, 200.1 h in aqueous solutions buffered at pH 7 and 66.9 h in aqueous solutions buffered at pH 9.
- Executive summary:
The determination of the hydrolysis rate of VEEA as a function of pH was based on the EEC-Directive 92/69 EEC, Part C, Methods for the determination of Ecotoxicity, C.7: "Abiotic degradation: Hydrolysis as a function of pH", EEC Publication no. L383, December 1992.
The test substance is hydrolytically unstable (half-life time at 25 °C < 1 day) in aqueous solutions buffered at pH 4.
The half-life time of test substance at 25 °C was 1.81 hours in aqueous solutions buffered at pH4.
The half-life time of test substance at 25 °C was 200.1 hours in aqueous solutions buffered at pH7.
The half-life time of test substance at 25 °C was 66.9 hours in aqueous solutions buffered at pH9.
Reference
- The actual temperature during the tests was measured in the 40 °C treatments and found to be 40.0 ± 0.5 °C
- No test substance was detected in the blank buffer solutions
Results of hydrolysis tests at pH 4, pH 7 and pH 9
Code pH and temperature |
Measured pH value |
Time [hours] |
Concentration test substance [mg/L] |
Relative concentration [%] |
Logarithm relative concentration |
pH 4- 30 °C |
4.01 |
0 |
876.9 |
100 |
2.00 |
|
0.5 |
679.8 |
77.5 |
1.89 |
|
|
0.67 |
608.7 |
69.4 |
1.74 |
|
|
0.83 |
549.6 |
62.7 |
1.70 |
|
|
1 |
504.7 |
57.6 |
1.76 |
|
|
1.17 |
456.4 |
52.0 |
1.72 |
|
|
1.33 |
417.9 |
47.7 |
1.68 |
|
|
1.67 |
346.0 |
39.5 |
1.60 |
|
4.01 |
2 |
287.0 |
32.7 |
1.51 |
|
pH 4- 40 °C |
4.02 |
0 |
874.8 |
100 |
2.00 |
|
0.25 |
688.9 |
78.8 |
1.90 |
|
|
0.33 |
636.8 |
72.8 |
1.86 |
|
|
0.5 |
538.1 |
61.5 |
1.79 |
|
|
0.67 |
419.0 |
47.9 |
1.68 |
|
|
0.83 |
312.8 |
35.8 |
1.55 |
|
4.01 |
1 |
292.3 |
33.4 |
1.52 |
|
pH 7- 30 °C |
6.88 |
0 |
971.0 |
100 |
2.00 |
|
48 |
727.6 |
74.9 |
1.87 |
|
|
61 |
677.7 |
69.8 |
1.84 |
|
|
65 |
651.1 |
67.1 |
1.83 |
|
|
69.5 |
652.5 |
67.2 |
1.83 |
|
|
84 |
592.8 |
61.1 |
1.79 |
|
|
89 |
582.3 |
60.0 |
1.78 |
|
|
94 |
559.1 |
57.6 |
1.76 |
|
|
108 |
507.5 |
52.3 |
1.72 |
|
|
114.5 |
487.3 |
50.2 |
1.70 |
|
6.88 |
132 |
446.0 |
45.9 |
1.66 |
|
pH 7- 40 °C |
6.90 |
0 |
928.0 |
100 |
2.00 |
|
22 |
666.6 |
71.8 |
1.86 |
|
|
30 |
578.9 |
62.4 |
1.80 |
|
|
48 |
415.6 |
44.8 |
1.65 |
|
|
56 |
381.5 |
41.1 |
1.61 |
|
|
60 |
350.1 |
37.7 |
1.58 |
|
6.89 |
72 |
286.8 |
30.9 |
1.49 |
|
pH 9- 30 °C |
9.14 |
0 |
952.9 |
100 |
2.00 |
|
14.2 |
718.8 |
75.4 |
1.88 |
|
|
16 |
714.5 |
75.0 |
1.87 |
|
|
18 |
674.8 |
70.8 |
1.85 |
|
|
20 |
662.8 |
69.6 |
1.84 |
|
|
23 |
627.8 |
65.9 |
1.82 |
|
9.15 |
40 |
465.6 |
48.9 |
1.69 |
|
pH 9- 40 °C |
9.16 |
0 |
916.7 |
100 |
2.00 |
|
|
5 |
670.3 |
73.1 |
1.86 |
|
|
8 |
592.1 |
64.6 |
1.81 |
|
|
10 |
564.2 |
61.5 |
1.79 |
|
|
13 |
478.5 |
52.2 |
1.72 |
|
|
15 |
428.3 |
46.7 |
1.67 |
|
9.15 |
18 |
363.1 |
39.6 |
1.60 |
Description of key information
Readily hydrolisable, pH dependent, transformation products unknown but readily biodegradable
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 200.1 h
- at the temperature of:
- 25 °C
Additional information
The submission item is hydrolytically instable under environmentally relevant conditions. The degradation half-life peaks around neutral pH 7 (ca. 200 hours) and is lower in acidic (ca. 2 hours at pH 4) or basic media (ca. 67 hours at pH 9). As it is in addition readily biodegradable the identification of hydrolysis products is considered not required and a full hydrolysis study with a radiolabelled test item was therefore not performed.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.