4-(1-piperidinyl)-2-(E)-butenoicacid hydrochloride

Guidance on Safe Use

First-aid measures

Description of First Aid Measures
Eye Contact: Flush with water while holding eyelids open for at least 15 minutes. Seek medical attention immediately.

Skin Contact:Remove contaminated clothing. Flush area with large amounts of water. Use soap. Seek medical attention.

Ingestion:Never give anything by mouth to an unconscious person. Wash out mouth with water. Do not induce vomiting unless directed by medical personnel. Seek medical attention immediately.

Inhalation:Remove to fresh air and keep patient at rest. Seek medical attention immediately.

Symptoms and Effects of Exposure: No data available

Medical Conditions
Aggravated by Exposure:None known

Indication of the Immediate Medical Attention and Special Treatment Needed
Notes to Physician: None

Fire-fighting measures

Extinguishing Media:
Extinguish fires with CO2, extinguishing powder, foam, or water.

Special Hazards Arising from the Substance or Mixture
Hazardous Combustion Products: Formation of toxic gases is possible during heating or fire. May include oxides of carbon and nitrogen and products of chlorine.

Fire / Explosion Hazards: Strong dust explosion characteristic. Very high sensitivity of a dust cloud to ignition, based on minimum ignition energy.

Advice for Fire-Fighters: During all fire fighting activities, wear appropriate protective equipment, including self-contained breathing apparatus.

Accidental release measures

Personal Precautions, Protective Equipment and Emergency Procedures
Personnel involved in clean-up should wear appropriate personal protective equipment (see below). Minimize exposure.

Environmental Precautions: Place waste in an appropriately labeled, sealed container for disposal. Care should be taken to avoid environmental release.

Methods and Material for Containment and Cleaning Up
Measures for Cleaning /Collecting: Contain the source of the spill if it is safe to do so. Collect spilled material by a method that
controls dust generation. Avoid use of a filtered vacuum to clean spills of dry solids, due to the potential for electrostatic discharge and the strong dust explosion potential and very high sensitivity to ignition.

Large Spills: Non-essential personnel should be evacuated from affected area. Report emergency situations immediately. Clean up operations should only be undertaken by trained personnel.

Handling and storage

Precautions for Safe Handling
All conductive elements of the system that contact the dry substance should be properly bonded and grounded and equipped
with proper explosion relief or suppression systems. This material should not be flowed through nonconductive ducts or pipes
because of the potential for electrostatic discharge ignition. Restricting the use of high resistivity materials, such as plastics,
should be considered. Minimize dust generation. Avoid open handling. Use local exhaust ventilation or perform work under fume
hood/fume cupboard. Avoid inhalation and contact with skin, eye, and clothing. When handling, use appropriate personal
protective equipment (see below). Wash hands and any exposed skin after removal of PPE. Releases to the environment
should be avoided. Review and implement appropriate technical and procedural waste water and waste disposal measures to
prevent occupational exposure or environmental releases. Potential points of process emissions of this material to the
atmosphere should be controlled with dust collectors, HEPA filtration systems or other equivalent controls.

Conditions for Safe Storage, Including any Incompatibilities
Storage Conditions: Store at room temperature in properly labeled containers. Keep away from heat, sparks and flames.

Specific end use(s):No data available

Transport information

Shipping

SpecialProvisions

Shipping

Remarks

Marine transport (UN RTDG/IMDG)

Shipping

Remarks

Shipping

Remarks

SpecialProvisions

Exposure controls / personal protection

Control Parameters
Pfizer OEL TWA-8 Hr:3000µg/m3, Severe Eye Irritant

Engineering Controls:
Engineering controls should be used as the primary means to control exposures. Use process containment, local exhaust ventilation, or other engineering controls to maintain airborne levels within the OEB range.

Personal Protective Equipment: Refer to applicable national standards and regulations in the selection and use of PPE.

Hands:Wear impervious gloves as minimum protection.

Eyes: Wear safety glasses as minimum protection.

Skin:Wear impervious protective clothing when handling this compound.

Respiratory protection: If the applicable Occupational Exposure Limit (OEL) is exceeded, wear an appropriate
respirator with a protection factor sufficient to control exposures to below the OEL.

Stability and reactivity

Reactivity: No data available

Chemical Stability: Stable under normal conditions of use.

Possibility of Hazardous Reactions
Oxidizing Properties: No data available

Conditions to Avoid: Fine particles (such as dust and mists) may fuel fires/explosions. Keep away from heat and other sources of ignition, including electrostatic discharge.

Incompatible Materials: As a precautionary measure, keep away from strong oxidizers

Hazardous Decomposition Products: No data available

Disposal considerations

Waste Treatment Methods:
Dispose of waste in accordance with all applicable laws and regulations. Member State specific and Community specific provisions must be considered. Considering the relevant known environmental and human health hazards of the material, review and implement
appropriate technical and procedural waste water and waste disposal measures to prevent occupational exposure and environmental release. It is recommended that waste minimization be practiced. The best available technology should be utilized to prevent environmental releases. This may include destructive techniques for waste and wastewater.