Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 244-848-1 | CAS number: 22224-92-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- July 1980
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Fenamiphos
- EC Number:
- 244-848-1
- EC Name:
- Fenamiphos
- Cas Number:
- 22224-92-6
- Molecular formula:
- C13H22NO3PS
- IUPAC Name:
- {ethoxy[3-methyl-4-(methylsulfanyl)phenoxy]phosphoryl}(propan-2-yl)amine
- Test material form:
- solid: crystalline
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- other: lutrol, warm
- Details on dermal exposure:
- TEST MATERIAL
- Amount applied: 0.05 - 2 mL - Duration of exposure:
- 24 h
- Doses:
- - 25, 35, 40, 45, 50, 65, 75, 100, 125, 1000 mg/kg bw (males)
- 25, 50, 75, 100, 125, 1000 mg/kg bw (females) - No. of animals per sex per dose:
- males: 5 animals/group at dose levels: 25 and 1000 mg/kg bw; 10 animals/group at dose levels 35, 40, 45, 50, 65, 100, 125 mg/kg bw; 20 animals at 75 mg/kg bw;
females: 5 animals/group at dose levels: 25 and 1000 mg/kg bw; 10 animals/group at dose levels 50, 75, 100, and 125 mg/kg bw - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 72 mg/kg bw
- Based on:
- test mat.
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 92 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Mortalitiy occured in male animals at and above doses of 45 mg/kg bw and at and above 75 mg/kg bw in females (please refer to Table 1 "Any other information on results incl. tables").
- Clinical signs:
- other: other: The following clinical symptoms were seen in male and female rats: apathy, laboured breathing, tremor, abdominal position, salivation, red lacrimation and soft faeces. Symptoms appeared in males after 66 min and in females after 41 min of exposure;
- Gross pathology:
- not specified
- Other findings:
- not specified
Any other information on results incl. tables
Table 1: Results summary
Dose [mg/kg bw] | Toxicological results* | |
male rats | female rats | |
25 | 0/5/5 | 0/5/5 |
35 | 0/10/10 | - |
40 | 0/10/10 | - |
45 | 1/10/10 | - |
50 | 3/10/10 | 0/10/10 |
65 | 4/10/10 | - |
75 | 11/20/20 | 2/10/10 |
100 | 8/10/10 | 6/10/10 |
125 | 9/10/10 | 9/10/10 |
1000 | 5/5/5 | 5/5/5 |
| LD50: 72 mg/kg bw | LD50: 92 mg/kg bw |
* 1st figure = number of dead animals / 2nd figure = number of animals with clinical signs / 3rd figure = number of animals in the group
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 based on GHS criteria
- Conclusions:
- The test item is toxic to rats following dermal administration in a lipophilic vehicle. The dermal LD50 of the test item in rats was 72 – 92 mg/kg bw in males and females, respectively.
- Executive summary:
In a acute dermal toxiciy study equivalent to OECD 402, the test item was dissolved, emulsified, suspended in Lutrol (warm) and applied under occlusive conditions to groups of non-fasted male and female rats for an exposure duration of 24 hours at dose levels of 25, 35, 40, 45, 50, 65, 75, 100, 125 and 1000 mg/kg bw. The treatment volume was 0.05 - 2 mL/kg bw. The recovery period was 14 days.
Mortalitiy occured in male animals at and above doses of 45 mg/kg bw and at and above 75 mg/kg bw in females. Clinical signs were observed in all animals and all dose levels (apathy, laboured breathing, tremor, abdominal position, salivation, red lacrimation and soft faeces).
It was concluded that the test item is toxic to rats following dermal administration in a lipophilic vehicle. The dermal LD50 of the test item in rats was 72 – 92 mg/kg bw in males and females, respectively.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
![ECHA](/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/echa_logo.png)