Registration Dossier
Registration Dossier
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EC number: 410-940-7 | CAS number: 60166-91-8 LACTOFTALURO
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1992
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1992
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: EEC B12 micronucleus
- GLP compliance:
- yes
- Type of assay:
- other: Non-bacteriological test in vivo - 6th amendment data
Test material
- Reference substance name:
- (S)-5-[2-(acetyloxy)propanamido]-2,4,6-triiodo-1,3-di(chloroformyl)benzene
- EC Number:
- 410-940-7
- EC Name:
- (S)-5-[2-(acetyloxy)propanamido]-2,4,6-triiodo-1,3-di(chloroformyl)benzene
- Cas Number:
- 60166-91-8
- Molecular formula:
- C13H8Cl2I3NO5
- IUPAC Name:
- 1-{[3,5-bis(carbonochloridoyl)-2,4,6-triiodophenyl]carbamoyl}ethyl acetate
- Test material form:
- solid: particulate/powder
1
Test animals
- Species:
- other: Sprague Dawley Crl:CD(SD)BR rats
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- 0.5% Methylcellulose (400 cps) in water.
- No. of animals per sex per dose:
- Female: 2000 mg/kg; No. of animals: ; Sacrifice times: hours
Results and discussion
Test results
- Sex:
- male/female
- Genotoxicity:
- negative
- Toxicity:
- yes
- Remarks:
- Doses producing toxicity: > 5000 mg/kg
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): negative
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