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Boiling point

Link to relevant study record(s)

Reference

Endpoint:

boiling point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2019-2020

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 103 (Boiling Point)

Version / remarks:

1995

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.2 (Boiling Temperature)

Version / remarks:

2008

Deviations:

no

Principles of method if other than guideline:

Not applicable.

GLP compliance:

yes (incl. QA statement)

Remarks:

Inspected on 15-16/11/2017, Signed on 15/05/2018

Type of method:

dynamic method

Key result

Boiling pt.:

> 170 °C

Atm. press.:

>= 999.3 - <= 1 007.9 mBar

Conclusions:

The boiling point of the test item should be stated as 409.79 °C in a boiling process beginning at 170 °C (dynamic method).

Executive summary:

An experimental study, conducted in accordance with conditions recommended in OECD guideline and under GLP, was performed. The main determination of the boiling point of the test item was determined with the method following Cottrell.

Two experiments were performed using the Dynamic method using Cottrell apparatus to determine the initial boiling point of the item.

Constant pumping of the Cottrell pump was observed at 222 °C (first determination) and 221 °C (second determination) whereas the thermometer in the Cottrell pump showed a much lower temperature than the temperature in the sample 180.8 °C (first determination) and 181.5 °C (second determination). The measured temperatures of the thermometer of the Cottrell pump are close to the value determined in the pre-test for the boiling point with 170 °C.

When a pure substance boils, the temperature should be similar to the temperature measured at the Cottrell pump. Considering this observation for complex substance, difference between the temperature of the Cottrell pump and the test vessel may be the sign of a decomposition.

By comparison the results of the dynamic method with the results of the second DSC pre-test measurement a turbulent baseline was observed after the first event since 100 °C. The turbulent behaviour might be cause through the boiling behaviour of the single components of the test item. This turbulent behaviour became more intense since 355 °C.

It can be supposed that the major fraction boils in a range of 355 °C to 430 °C with a maximum of 409.79°C.

The values determined with the Dynamic method represent only a part of the boiling behaviour of the test item. The higher boiling components could not be caught or covered.

Therefore, taking all measurements into account, the boiling point of the test item should be stated as 409.79 °C in a boiling process beginning at 170 °C.

No observations were made which might cause doubts on the validity of the study outcome. Therefore, the result of the study is considered valid.

Description of key information

The boiling point of the test item should be stated as 409.79 °C in a boiling process beginning at 170 °C.

Additional information

An experimental study, conducted in accordance with conditions recommended in OECD guideline and under GLP, was performed. It should be considered as a key study. The result should be retained as key data.