Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 482-150-0 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Particle size distribution (Granulometry)
Administrative data
- Endpoint:
- particle size distribution (granulometry)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- The study was conducted between 18 July 2007 and 29 August 2007.
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 007
- Report date:
- 2007
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- cascade impaction
- Type of distribution:
- mass based distribution
Test material
- Reference substance name:
- Magenta T-43
- IUPAC Name:
- Magenta T-43
- Test material form:
- solid: particulate/powder
- Details on test material:
- Sponsor's identification: MAGENTA T-43
Description: dark red solid
Storage conditions: room temperature, in the dark
Lot number: H186-5
Constituent 1
Results and discussion
Particle size distribution at different passagesopen allclose all
- No.:
- #1
- Size:
- 100 µm
- Distribution:
- 60.5 %
- Remarks on result:
- other: Proportion of test material having an inhalable particle size, sieve method
- No.:
- #2
- Size:
- 10 µm
- Distribution:
- 1.77 %
- Remarks on result:
- other: Proportion of test material having a thoracic particle size, cascade impactor method
- No.:
- #3
- Size:
- 5.5 µm
- Distribution:
- 0.21 %
- Remarks on result:
- other: Proportion of test material having a respirable particle, cascade impactor method
Any other information on results incl. tables
Results
Definitive test (cascade impactor method)
The results of the cascade impactor method were tabulated.
Cascade Impactor: Determination 1
Cup Number |
Particle Size Range Collected (µM) |
Cup Masses (g) |
||
Pre-Sampling |
Post-Sampling |
Difference |
||
1 |
>10.0 |
86.1398 |
89.1390 |
2.9992 |
2 |
5.5-10.0 |
85.4742 |
85.5283 |
0.0541 |
3 |
2.4-5.5 |
85.8849 |
85.8896 |
0.0047 |
4 |
1.61-2.4 |
85.6339 |
85.6346 |
0.0007 |
5 |
0.307-1.61 |
85.7772 |
85.7774 |
0.0002 |
Filter |
<0.307 |
75.1904 |
75.1916 |
0.0012 |
Amount of test material found in artificial throat: 0.03 g.
Total amount of test material recovered from impactor cups, filter and artificial throat: 3.0901 g.
The cumulative amounts found for the individual particle size cut-points (µm) were tabulated.
Particle size cut-points: Determination 1
Cup number |
Particle Size Cut-Points (µm) |
Cumulative Mass of Test Material (g) |
Cumulative Amount of Test Material (%) |
2 |
10.0 |
0.0609 |
1.97 |
3 |
5.5 |
0.0068 |
0.220 |
4 |
2.4 |
0.0021 |
6.80 x 10-2 |
5 |
1.61 |
0.0014 |
4.53 x 10-2 |
Filter |
0.307 |
0.0012 |
3.88 x 10-2 |
Cascade Impactor: Determination 2
The results of the cascade impactor method were tabulated.
Cup Number |
Particle Size Range Collected (µM) |
Cup Masses (g) |
||
Pre-Sampling |
Post-Sampling |
Difference |
||
1 |
>10.0 |
86.1400 |
89.1299 |
2.9899 |
2 |
5.5-10.0 |
85.4741 |
85.5111 |
0.0370 |
3 |
2.4-5.5 |
85.8848 |
85.8884 |
0.0036 |
4 |
1.61-2.4 |
85.6339 |
85.6351 |
0.0012 |
5 |
0.307-1.61 |
85.7770 |
85.7774 |
0.0004 |
Filter |
<0.307 |
75.1877 |
75.1881 |
0.0004 |
Amount of test material found in artificial throat: 0.01 g.
Total amount of test material recovered from impactor cups, filter and artificial throat: 3.0425 g.
The cumulative amounts found for the individual particle size cut-points (µm) were tabulated.
Particle size cut-points: Determination 2
Cup number |
Particle Size Cut-Points (µm) |
Cumulative Mass of Test Material (g) |
Cumulative Amount of Test Material (%) |
2 |
10.0 |
0.0426 |
1.40 |
3 |
5.5 |
0.0056 |
0.184 |
4 |
2.4 |
0.0020 |
6.57 x 10-2 |
5 |
1.61 |
0.0008 |
2.63 x 10-2 |
Filter |
0.307 |
0.0004 |
1.32 x 10-2 |
Cascade Impactor: Determination 3
The results of the cascade impactor method were tabulated.
Cup Number |
Particle Size Range Collected (µM) |
Cup Masses (g) |
||
Pre-Sampling |
Post-Sampling |
Differencei |
||
1 |
>10.0 |
86.1408 |
89.1298 |
2.9890 |
2 |
5.5-10.0 |
85.4746 |
85.5273 |
0.0527 |
3 |
2.4-5.5 |
85.8854 |
85.8893 |
0.0039 |
4 |
1.61-2.4 |
85.6339 |
85.6346 |
0.0007 |
5 |
0.307-1.61 |
85.7775 |
85.7776 |
0.0001 |
Filter |
<0.307 |
75.1845 |
75.1867 |
0.0022 |
Amount of test material found in artificial throat: 0.01 g.
Total amount of test material recovered from impactor cups, filter and artificial throat: 3.0586 g.
The cumulative amounts found for the individual particle size cut-points (µm) were tabulated.
Particle size cut-points: Determination 3
Cup number |
Particle Size Cut-Points (µm) |
Cumulative Mass of Test Material (g) |
Cumulative Amount of Test Material (%) |
2 |
10.0 |
0.0596 |
1.95 |
3 |
5.5 |
0.0069 |
0.226 |
4 |
2.4 |
0.0030 |
9.81 x 10-2 |
5 |
1.61 |
0.0023 |
7.52 x 10-2 |
Filter |
0.307 |
0.0022 |
7.19 x 10-2 |
The overall cumulative amounts of test material with a particle size less than 10.0 µm (%)from Determinations 1 to 3 were tabulated.
Determination |
Cumulative Amount of Test Material Less Than 10.0 µm (%) |
Mean Cumulative Amount of Test Material Less Than 10.0 µm (%) |
1 |
1.97 |
1.77 |
2 |
1.40 |
|
3 |
1.95 |
The overall cumulative amounts of test material with a particle size less than 5.5 µm (%) from Determinations 1 to 3 were tabulated.
Determination |
Cumulative Amount of Test Material Less Than 5.5 µm (%) |
Mean Cumulative Amount of Test Material Less Than 5.5 µm (%) |
1 |
0.220 |
0.210 |
2 |
0.184 |
|
3 |
0.226 |
Concluding Particle Size Data
Measurement |
Method |
Result |
Proportion of test material having an inhalable particle size < 100µm |
Sieve |
60.5% |
Proportion of test material having a thoracic particle size < 10.0 µrn |
Cascade Impactor |
1.77% |
Proportion of test material having a respirable particle size < 5.5 µm |
Cascade Impactor |
0.210% |
Applicant's summary and conclusion
- Conclusions:
- The proportion of test material having an inhalable particle size less than 100 µm = 60.5% by the sieve method.
The proportion of test material having a thoracic particle size less than 10 µm = 1.77% by the cascade impactor method.
The proportion of test material having a respirable particle size less than 5.5 µm = 0.210% by the cascade impactor method.
Mass Median Diameter: Too few particles were of a size less than 10 µm to allow accurate assessment of mass median aerodynamic diameter. - Executive summary:
The particle size distribution of substance Magenta T-43 was determined to have 60.5% inhalable particle size < 100 µm by the sieve method; 1.77 % thoracic particle size < 10 µm by the cascade impactor method and 0.210% respirable particle size < 5.5 µm by the cascade impactor method, according to the OECD Test Guideline 110.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.