Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 831-167-5 | CAS number: 2126827-44-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
In a reliable in vitro skin corrosion study human skin tissue (eipdermis keratinocytes) was exposed to undiluted substance for 3 and 60 minutes. There was 94% and 100 % tissue viability following the 3- and 60-minutes exposure, respectively. Resultantly, the substance considered as non-corrosive to human skin.
In a reliable in vitro skin irritation study conducted on the substance the mean value of relative tissue viability was 74% following a 15-minutes exposure to undiluted substance. This value is above the threshold for skin irritation (50%). Therefore, the substance is considered to be as non-irritant to human skin.
In a reliable in vitro eye irritation study employing bovine cornea were exposed to the undiluted substance for 4 hours. Opacity and permeability values were measured. There was a mean IVIS score of -0.4 following the 4-hour exposure point. Resultantly, the test material is considered to be non-irritant to the eye.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin corrosion: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 6th February 2019 - 8th February 2019
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 431 (In Vitro Skin Corrosion: Reconstructed Human Epidermis (RHE) Test Method)
- Version / remarks:
- Adopted 29th July 2016
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: EC Guideline No. 440/2008. Part B: Methods for the Determination of Toxicity and other health effects, Guideline B.40 BIS: "In Vitro Skin Corrosion: Human Skin Model Test".
- Version / remarks:
- Official Journal of the European Union No. L142, 31 May 2008.
- Deviations:
- no
- GLP compliance:
- yes
- Specific details on test material used for the study:
- Batch (Lot) Number: 2715/18/01
Expiry date: 01 July 2020
Physical Description: Dark green solid
Purity/Composition: 99%
Storage Conditions: At room temperature protected from light - Test system:
- human skin model
- Source species:
- human
- Cell type:
- non-transformed keratinocytes
- Cell source:
- other: Cultured to form a multilayered, highly differentiated model of the human epidermis
- Source strain:
- other: Not applicable
- Details on animal used as source of test system:
- EpiDerm Skin Model (EPI-200, Lot no.: 29944 Kit I and J).
- Justification for test system used:
- Recommended system according to the OECD 431 and EC TG.
- Vehicle:
- unchanged (no vehicle)
- Details on test system:
- The model consists of normal, human-derived epidermal keratinocytes which have been cultured to form a multilayered, highly differentiated model of the human epidermis. It consists of organized basal, spinous and granular layers, and a multi-layered stratum corneum containing intercellular lamellar lipid layers arranged in patterns analogous to those found in vivo. The EpiDerm tissues (surface 0.6 cm²) were cultured on polycarbonate membranes of 10 mm cell culture inserts.
- Control samples:
- yes, concurrent negative control
- yes, concurrent positive control
- yes, concurrent MTT non-specific colour control
- Amount/concentration applied:
- Substance: 25.4 to 41.6 mg per tissue
Positive control: 50 μL per tissue
Negative control: 50 μL per tissue - Duration of treatment / exposure:
- 3 minutes and 60 minutes
- Duration of post-treatment incubation (if applicable):
- 3 hours at 37°C in air containing 5% CO2.
- Number of replicates:
- Duplicate
- Irritation / corrosion parameter:
- % tissue viability
- Remarks:
- 3-minute time point
- Run / experiment:
- mean of two samples
- Value:
- ca. 94
- Vehicle controls validity:
- not applicable
- Negative controls validity:
- valid
- Positive controls validity:
- valid
- Remarks on result:
- other: No indication of corrosion
- Irritation / corrosion parameter:
- % tissue viability
- Remarks:
- 60 minute time point
- Run / experiment:
- Mean of two samples
- Value:
- ca. 100
- Vehicle controls validity:
- not applicable
- Negative controls validity:
- valid
- Positive controls validity:
- valid
- Remarks on result:
- other: No indication of corrosion
- Other effects / acceptance of results:
- The non-specific reduction of MTT by the substance was -7.4% and 2.2% of the negative control tissues after 3 minutes and 1 hour, respectively.
In addition to the normal 3-minute and 1-hour procedure, two tissues were treated with substance instead of MTT solution these tissues were incubated with DMEM. The color interference by the substance was 5.4% and 7.3% of the negative control tissues after 3 minutes and 1 hour respectively.
For the true tissue viability to be calculated, in addition to the normal 3-minute and 1-hour procedure, two freeze-killed tissues treated with test item were used but instead of MTT solution these tissues were incubated with DMEM. The nonspecific color in freeze-killed tissues by the substance was 2.8% and 4.4% of the negative control tissues after 3 minutes and 1 hour respectively. - Interpretation of results:
- GHS criteria not met
- Conclusions:
- The substance is not corrosive in the in vitro skin corrosion test under the experimental conditions described in this study.
- Executive summary:
In a reliable in vitro skin corrosion study, conducted according to the OECD Guideline 431, 'In Vitro Skin Corrosion: reconstructed human epidermis (RHE) test method', the undiluted substance ( 25.4 to 41.6 mg) was applied onto reconstructed human skin tissue (epidermal model, EpiDerm tissue (0.6 cm²)) in duplicate for a period of 3 or 60 minutes.
Skin corrosion is expressed as the remaining cell viability after exposure to the substance. The relative mean tissue viability obtained after 3-minute and 1-hour treatments with the substance compared to the negative control tissues was 94 % and 100 %, respectively. Because the mean relative tissue viability for the substance was not below 50% after the 3-minute treatment and not below 15% after the 1-hour treatment the substance is considered to be non corrosive.
In conclusion, the substance is not corrosive in the in vitro skin corrosion test under the experimental conditions described in this study.
- Endpoint:
- skin irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 26th March 2019 - 1st April 2019
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- OECD Guideline study.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 439 (In Vitro Skin Irritation: Reconstructed Human Epidermis Test Method)
- Version / remarks:
- Adopted 28 July 2015
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.46 (In Vitro Skin Irritation: Reconstructed Human Epidermis Model Test)
- Version / remarks:
- No. 440/2008. Official Journal of the European Union No. L142; Amended by EC No. 640/2012 OJ No. L193, 20 July 2012
- Deviations:
- no
- GLP compliance:
- yes
- Specific details on test material used for the study:
- Batch (Lot) Number: 2715/18/01
Expiry date: 01 July 2020 (expiry date)
Physical Description: Dark green solid
Purity/Composition: 99%
Storage Conditions: At room temperature protected from light - Test system:
- human skin model
- Source species:
- other: Not applicable
- Cell type:
- non-transformed keratinocytes
- Cell source:
- other: EPISKIN Small Model TM
- Source strain:
- other: Not applicable
- Justification for test system used:
- One of the validated in vitro skin irritation tests is the EPISKIN test, which is recommended in international guidelines (e.g. OECD and EC).
- Vehicle:
- unchanged (no vehicle)
- Details on test system:
- EPISKIN Small ModelTM (EPISKIN-SMTM), 0.38 cm2.
This model is a three-dimensional human epidermis model, which consists of adult human-derived epidermal keratinocytes which have been seeded on a dermal substitute consisting of a collagen type I matrix coated with type IV collagen. The keratinocytes are cultured for 13-days, which results in a highly differentiated and stratified epidermis model comprising the main basal, supra basal, spinous and granular layers and a functional stratum corneum.
Source.
SkinEthic Laboratories, Lyon, France. - Control samples:
- yes, concurrent negative control
- yes, concurrent positive control
- Amount/concentration applied:
- 10 mg of substance (tissue moistened with 5 µL Milli-Q water prior to the application).
- Duration of treatment / exposure:
- 15 ± 0.5 minutes at room temperature.
- Duration of post-treatment incubation (if applicable):
- 42 ± 1 hours at 37°C.
- Number of replicates:
- Triplicate
- Irritation / corrosion parameter:
- % tissue viability
- Remarks:
- maen of three
- Run / experiment:
- 1
- Value:
- 74
- Vehicle controls validity:
- valid
- Negative controls validity:
- valid
- Positive controls validity:
- valid
- Remarks on result:
- no indication of irritation
- Other effects / acceptance of results:
- Because a color change was observed in aqueous conditions and by adding MTT-medium it was concluded that the substance did interact with the MTT endpoint.
In addition to the normal procedure, three freeze-killed tissues treated with substance and three freeze-killed non-treated tissues were used for the cytotoxicity evaluation with MTT. The non-specific reduction of MTT by the substance was 12% of the negative control tissues. The net OD of the treated killed tissues was subtracted from the ODs of the substance treated viable tissues.
In addition to the normal procedure, three tissues were treated with substance. Instead of MTT solution the tissues were incubated with assay medium. The non-specific color by the substance was 10% of the negative control tissues. The OD of the tissue incubated with assay medium was subtracted from the ODs of the substance treated tissues incubated with MTT medium.
For the true tissue viability to be calculated, three freeze-killed tissues treated with substance were measured but instead of MTT solution these tissues were incubated with assay medium.
The nonspecific color in freeze-killed tissues by the substance was 9.7% of the negative control tissues. - Interpretation of results:
- GHS criteria not met
- Conclusions:
- The substance is non-irritant in the in vitro skin irritation test under the experimental conditions described in this study.
- Executive summary:
In an in vitro skin irritation study conducted according to OECD TG 439 ‘In vitro Skin Irritation: Reconstructed Human Epidermis Test Method’ human skin tissue (eipdermis keratinocytes) was exposed to the undiluted (10 mg) substance for 15-minutes at room temperature. Following the exposure, the substance was rinsed and incubated for further 42 ± 1 hours at 37°C in fresh medium. There was 74 % tissue viability following the 15-minute exposure point. This value is above the threshold for skin irritation (50%). Resultantly, the substance is considered to be a non-irritant to human skin.
Referenceopen allclose all
Mean Absorption in the in vitro Skin Corrosion Test
|
3 -minute application viability (%) |
1 -hour application viability (%) |
||||||
A (OD570) |
B (OD570) |
Mean (OD570) |
SD (+/-) |
A (OD570) |
B (OD570) |
Mean (OD570) |
SD (+/-) |
|
Negative control |
1.375 |
1.511 |
1.443 |
0.097 |
1.316 |
1.538 |
1.427 |
0.157 |
Substance* |
1.279 |
1.423 |
1.351 |
0.101 |
1.281 |
1.562 |
1.422 |
0.199 |
Positive control |
0.511 |
0.324 |
0.087 |
0.132 |
0.250 |
0.117 |
0.183 |
0.094 |
SD = Standard deviation
Duplicate exposures are indicated by A and B.
* For the 3 minute exposure the substance values are corrected for the color interference (5.4%).
For the 1 hour exposure the substance values are corrected for the non-specific MTT reaction and color interference (2.2%
and 7.3 %, respectively). In addition these values are corrected for the nonspecific color in freeze-killed tissues (4.4%).
The values are corrected for background absorption (0.0475). Isopropanol was used to measure the background absorption.
Mean Tissue Viability in the in vitro Skin Corrosion Test
3 -minute application viability (% of control) |
1 -hour application viability (% of control) |
|
Negative control | 100 | 100 |
Substance | 94 | 100 |
Positive control | 29 | 13 |
Mean absorption in the In Vitro Skin Irritation Test with substance
A (OD570) | B (OD570) | C (OD570) | Mean (OD570) | SD (+/-) | |
Negative Control | 1.0820 | 1.010 | 1.063 | 1.052 | 0.037 |
Substance | 0.862 | 0.908 | 0.579 | 0.783 | 0.178 |
Positive Control | 0.055 | 0.045 | 0.118 | 0.072 | 0.040 |
OD = optical density
SD = Standard deviation
* The substance values are corrected for the non-specific MTT reaction and color interference.
Triplicate exposures are indicated by A, B and C.
In this table the values are corrected for background absorption (0.046). Isopropanol was used to measure the background absorption.
Mean Tissue Viability in the In Vitro Skin Irritation Test with the substance
Mean tissue viability (percentage of control) | Standard deviation (percentage) | |
Negative Control | 100 | 3.5 |
Substance | 74 | 17 |
Positive Control | 6.9 | 3.8 |
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 18th February 2019 - 19th February 2019
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 437 (Bovine Corneal Opacity and Permeability Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage)
- Version / remarks:
- Adopted October 09, 2017
- Deviations:
- no
- GLP compliance:
- yes
- Specific details on test material used for the study:
- Batch (Lot) Number: 2715/18/01
Expiry date: 01 July 2020 (expiry date)
Physical Description: Dark green solid
Purity/Composition: 99%
Storage Conditions: At room temperature protected from light
Additional information.
Test Facility test item number: 210026/A
Purity/Composition correction factor: No correction factor required
Test item handling: Use amber glassware or wrap container in aluminum foil - Species:
- cattle
- Strain:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent positive control
- yes, concurrent negative control
- Amount / concentration applied:
- 356 to 369 mg
- Duration of treatment / exposure:
- for 240 +/- 10 minutes at 32 +/- 1 °C.
- Duration of post- treatment incubation (in vitro):
- Opacity determined directly after the treatment; Permiability determined after post-treatment incubation of 90 +/- 5 minutes at 32 +/- 1 °C.
- Number of animals or in vitro replicates:
- Triplicate.
- Details on study design:
- Test System.
Test System: Bovine eyes were used as soon as possible after slaughter.
Source:
Bovine eyes from young cattle were obtained from the slaughterhouse (Vitelco, -'s Hertogenbosch, The Netherlands), where the eyes were excised by a slaughterhouse employee as soon as possible after slaughter.
Transport:
Eyes were collected and transported in physiological saline in a suitable container under cooled conditions.
Preparation of Corneas.
The eyes were checked for unacceptable defects, such as opacity, scratches, pigmentation and neovascularization by removing them from the physiological saline and holding them in the light. Those exhibiting defects were discarded.
The isolated corneas were stored in a petri dish with cMEM (Earle’s Minimum Essential Medium (Life Technologies, Bleiswijk, The Netherlands) containing 1% (v/v) L-glutamine (Life Technologies) and 1% (v/v) Fetal Bovine Serum (Life Technologies)). The isolated corneas were mounted in a corneal holder (one cornea per holder) of BASF (Ludwigshafen, Germany) with the endothelial side against the O-ring of the posterior half of the holder. The anterior half of the holder was positioned on top of the cornea and tightened with screws. The compartments of the corneal holder were filled with cMEM of 32 +/- 1 °C. The corneas were incubated for the minimum of 1 hour at 32 +/- 1 °C.
Cornea Selection and Opacity Reading.
After the incubation period, the medium was removed from both compartments and replaced with fresh cMEM. Opacity determinations were performed on each of the corneas using an opacitometer (BASF-OP3.0, BASF, Ludwigshafen, Germany). The opacity of each cornea was read against a cMEM filled chamber, and the initial opacity reading thus determined was recorded. Corneas that had an initial opacity reading higher than 7 were not used. Three corneas were selected at random for each treatment group.
Substance Preparation.
No correction will be made for the purity/composition of the substance.
Since no workable suspension of the substance in physiological saline could be obtained, the substance was used as delivered by the sponsor and added pure on top of the corneas.
To protect the substance from light, amber-colored glassware or tubes wrapped in tin-foil were used for substance preparations.
Treatment of Corneas and Opacity Measurements.
The medium from the anterior compartment was removed and 750 ul of the negative control and 20% (w/v) Imidazole solution (positive control) were introduced onto the epithelium of the cornea. The substance was weighed in a bottle and applied directly on the corneas in such a way that the cornea was completely covered (356 to 369 mg). The holder was slightly rotated, with the corneas maintained in a horizontal position, to ensure uniform distribution of the solutions over the entire cornea. Corneas were incubated in a horizontal position for 240 +/- 10 minutes at 32 +/- 1°C. After the incubation the solutions and the substance were removed and the epithelium was washed at least three times with MEM with phenol red (Earle’s Minimum Essential Medium Life Technologies). Possible pH effects of the substance on the corneas were recorded. Each cornea was inspected visually for dissimilar opacity patterns. The medium in the posterior compartment was removed and both compartments were refilled with fresh cMEM and the opacity determinations were performed. - Irritation parameter:
- in vitro irritation score
- Run / experiment:
- 1
- Value:
- 0.1
- Vehicle controls validity:
- not applicable
- Negative controls validity:
- valid
- Positive controls validity:
- valid
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- in vitro irritation score
- Run / experiment:
- 2
- Value:
- -2.1
- Vehicle controls validity:
- not applicable
- Negative controls validity:
- valid
- Positive controls validity:
- valid
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- in vitro irritation score
- Run / experiment:
- 3
- Value:
- 0.8
- Vehicle controls validity:
- not applicable
- Negative controls validity:
- valid
- Positive controls validity:
- valid
- Remarks on result:
- no indication of irritation
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The results of an eye corrosion/irritation study employing isolated bovine cornea exposed to undiluted substance for 240-minutes indicate that it is a non-irritant to the eye.
- Executive summary:
In a reliable in vitro eye irritation study, conducted according to OECD Guideline 437, ‘Bovine Corneal Opacity and Permeability Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage’, the ability of the substance to induce opacity and permeability in an isolated bovine cornea were determined.
The substance was applied undiluted (356 - 369 mg) onto corneas (n=3) for a period of 240 minutes, followed by rinsing of the substance. The opacity of the corneas was then determined. The permeability measurements were determined after 90 minutes of incubation with fluorescein. The results of an eye corrosion/irritation study show that the mean in vitro irritance score was -0.4, indicating that that the substance is non-irritant to the eye.
Reference
Opacity Score.
Treatment |
Opacity before treatment |
Opacity after treatment |
Final Opacity1 |
Negative control corrected Final Opacity2 |
Mean Final Opacity |
|
|
||||||
Negative control |
4.1 |
5.4 |
1.2 |
|
0.7 |
|
3.4 |
3.5 |
0.1 |
||||
4.3 |
5.3 |
0.9 |
||||
|
||||||
Positive control |
4.6 |
160.2 |
155.6 |
155 |
137 |
|
3.2 |
113.1 |
109.9 |
109 |
|||
3.1 |
149.6 |
146.5 |
146 |
|||
|
||||||
Substance |
3.4 |
4.3 |
1.0 |
0.2 |
-0.6 |
|
3.4 |
2.3 |
-1.1 |
-1.8 |
|||
4.5 |
5.0 |
0.5 |
-0.3 |
1 Final Opacity = Opacity after treatment – Opacity before treatment.
2 Negative control corrected Final Opacity = Final opacity – Mean final opacity negative control
In vitro Irritancy Score.
Treatment |
Final Opacity2 |
Final OD4902 |
In vitro Irritancy Score1 |
|
|||
Negative control |
1.2 |
0.001 |
1.2 |
0.1 |
0.023 |
0.4 |
|
0.9 |
0.010 |
1.1 |
|
|
|||
Positive control |
155 |
1.225 |
173 |
109 |
2.577 |
148 |
|
146 |
1.733 |
172 |
|
|
|||
Substance |
-0.2 |
-0.008 |
0.1 |
-1.8 |
-0.019 |
-2.1 |
|
-0.3 |
0.072 |
0.8 |
1 In vitro irritancy score (IVIS) = opacity value + (15 x OD490 value).
2 Positive control and substance are corrected for the negative control.
Permeability Score (uncorrected).
Treatment |
Dilution factor |
OD490 1 |
OD490 2 |
OD490 3 |
Average OD |
Final OD |
Mean final negative control |
|||||
|
||||||||||||
Negative control |
1 |
0.001 |
0.001 |
0.001 |
0.001 |
0.001 |
0.011 |
|||||
1 |
0.026 |
0.028 |
0.016 |
0.023 |
0.023 |
|||||||
1 |
0.007 |
0.007 |
0.016 |
0.010 |
0.010 |
|||||||
|
|
|||||||||||
Positive control |
1 |
1.229 |
1.240 |
1.241 |
1.237 |
1.237 |
|
|||||
6 |
0.442 |
0.440 |
0.441 |
0.441 |
2.646 |
|
||||||
6 |
0.300 |
0.300 |
0.301 |
0.300 |
1.802 |
|
||||||
|
|
|||||||||||
Substance |
1 |
0.003 |
0.003 |
0.004 |
0.003 |
0.003 |
|
|||||
1 |
-0.008 |
-0.008 |
-0.007 |
-0.008 |
-0.008 |
|
||||||
1 |
0.086 |
0.082 |
0.082 |
0.083 |
0.083 |
|
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
Based on the findings of a reliable in vitro skin irritation, skin corrosion and eye irritation studies conducted on the substance, classification of the substance is not justified.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.