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Diss Factsheets
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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Details on sampling:
- The prepared test concentration along with the negative control was analyzed for the test item concentration at the beginning and end of test. For analysis, single composite sample was drawn from prepared test concentration and duplicate sample was drawn from the negative control.
- Vehicle:
- yes
- Remarks:
- reconstituted water
- Details on test solutions:
- To prepare test concentration of 100 mg/L, 100 mg test item was mixed and made up to 1L in a volumetric flask using test medium separately.
For negative control (GI), 1L test medium was used.
A stock solution of reference substance (Potassium dichromate) at 1 mg/mL was prepared by mixing 10 mg in 10 mL of test medium. For preparation of reference substance at 0.32 mg/L (G3), 0.32 mL of reference substance stock was mixed and made up to 1L in a volumetric flask using test medium.
150 mL of prepared negative control, test item concentrations and reference substance was dispensed separately into 4 test containers. - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Age at study initiation (mean and range, SD): Less than 24 hours (Neonates)
- Source: Ecotoxicology lab, Eurofins Advinus ltd.
- Feeding during test: Chlorella Vulgaris.
- Food type: unicellular green alga.
ACCLIMATION
- Acclimation conditions (same as test or not): Yes
- Type and amount of food: Chlorella Vulgaris
- Health during acclimation (any mortality observed): No - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Test temperature:
- Range finding : 20.3 to 20.5 degree celcius
Definitive test : 20.3 to 20.4 degree celcius - pH:
- Range finding : 7.70 to 7.81
Definitive test : 7.79 to 7.81 - Dissolved oxygen:
- Range finding : 7.0 to 7.4
Definitive test : 7.0 to 7.3 - Nominal and measured concentrations:
- Range finding test: 0.00001, 0.0001, 0.001, 0.01, 0.1, 1, 10 and 100 mg/L
Limit test: 100 mg/L - Details on test conditions:
- VEHICLE CONTROL PERFORMED: yes
- Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate
- Key result
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- Range finding study : No immobility of daphnia was observed in negative control and at any of the tested concentration.
Main study: No immobility observed with negative control and at 100 mg/L test concentration. - Results with reference substance (positive control):
- At 0.32 mg/L reference substance, the immobilization of daphnia was 50 and 60% at 24 and 48 hours exposure respectively.
- Validity criteria fulfilled:
- yes
- Conclusions:
- The EC50 value for FAT 41047/A TE at 48 hours is higher than 100 mg/L.
- Executive summary:
The acute immobilization effect of the test item FAT 41047/A TE was studied on Daphnia magna according to OECD test guideline 202.
A range finding test was carried out to determine the test concentration for the definitive test, where Daphnia magna less than 24 hours old were exposed to the test item concentrations of 0.00001, 0.001, 0.01, 0.1, 1.0, 10 and 100 mg/L along with the negative control in test medium (reconstituted water) at 20 ± 1 °C. No immolisation was observed at any of the test concentrations during the range finding test.
Based on the results of range finding test, in definitive test, Daphnia magna less than 24 hours old were exposed to limit test concentrations of 100 mg/L along with a negative control and a reference substance, potassium dichromate at 0.32 mg/L in test medium (reconstituted water) at 20 ± 1 °C. The number of daphnia immobilized was recorded at 24 and 48 hours exposure.
There was no immobilization of daphnia in the negative control and the limit test concentration of 100 mg/L up to 48 hours exposure. At 0.32 mg/L reference substance, the immobilization of daphnia was 50 and 60 % at 24- and 48-hours exposure, respectively.
The analytical test concluded that the test item stable in the test medium up to 49 hours at 1.09 and 109.00 mg/L claimed concentrations. The active ingredient concentration analysis in all test concentrations showed that the per cent agreement with claimed concentration was 75.4% at the start of test and 93.93 % at end of test (48 hours) which is within the acceptable limit.
Hence based on the findings of the study, the EC50 value for FAT 41047/A TE at 48 hours is higher than 100 mg/L.
Reference
Description of key information
The EC50 value for FAT 41047/A TE at 48 hours is higher than 100mg/L.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 100 mg/L
Additional information
The acute immobilization effect of the test item FAT 41047/A TE was studied on Daphnia magna according to OECD test guideline 202.
A range finding test was carried out to determine the test concentration for the definitive test, where Daphnia magna less than 24 hours old were exposed to the test item concentrations of 0.00001, 0.001, 0.01, 0.1, 1.0, 10 and 100 mg/L along with the negative control in test medium (reconstituted water) at20 ± 1 °C. No immolisation was observed at any of the test concentrations during the range finding test.
Based on the results of range finding test, in definitive test,Daphnia magnaless than 24 hours old were exposed to limit test concentrations of100 mg/L along with a negative control and a reference substance, potassium dichromate at 0.32 mg/Lin test medium (reconstituted water) at 20 ± 1 °C. The number of daphnia immobilized was recorded at 24 and 48 hours exposure.
There was no immobilization of daphnia in the negative control and the limit test concentration of 100 mg/L up to 48 hours exposure. At0.32 mg/L reference substance, the immobilization of daphnia was 50 and 60 % at 24- and 48-hours exposure, respectively.
The analytical test concluded that the test item stable in the test medium up to 49 hours at 1.09 and 109.00 mg/L claimed concentrations. The active ingredient concentration analysis in all test concentrations showed that the per cent agreement with claimed concentration was 75.4% at the start of test and 93.93 % at end of test (48 hours) which is within the acceptable limit.
Hence based on the findings of the study, the EC50 value for FAT 41047/A TE at 48 hours is higher than 100 mg/L.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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