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Diss Factsheets
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EC number: 951-918-1 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Repeated dose toxicity studies are available for samples of gasoline involving exposure by oral, inhalation and dermal routes. The only consistent systemic finding was male rat nephropathy, mediated by accumulation of alpha 2 micro globulin in the kidney tubules. This finding is specific to the male rat and is not relevant to human health.
Any further testing on the registered substance will be waived based on the composition which contains > 0.1% benzene (Classification H340; Cat 1B)
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Study duration:
- subacute
- Species:
- rat
Repeated dose toxicity: inhalation - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEC
- 1 402 mg/m³
- Study duration:
- chronic
- Species:
- rat
Repeated dose toxicity: inhalation - local effects
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Repeated dose toxicity: dermal - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 0.038 mg/kg bw/day
- Study duration:
- chronic
- Species:
- mouse
Repeated dose toxicity: dermal - local effects
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Study duration:
- chronic
- Species:
- mouse
Additional information
Repeated exposure of rats by inhalation to unleaded gasoline and naphtha blending stocks produced minor effects and only at the highest levels tested. Reported changes included body weight effects, organ weight changes, variations in hematologic parameters, and red nasal discharge. The only pathological findings reported were changes in male rat kidneys associated with alpha-2u-globulin-induced renal nephropathy, a male rat specific finding that is not relevant for human health. The NOAEC was 1402 mg/m3, based on a body weight effect at higher exposure concentrations.
In a chronic dermal study in mice, there were no discernible systemic effects, indicating that gasoline has a very low potential for systemic toxicity. The only effect of note was moderate to severe dermal irritation at the application site.
The only oral toxicity study identified involved repeated administration of gasoline to male rats to investigate the potential of gasoline and other light hydrocarbon streams to cause alpha 2 micro globulin mediated nephropathy in rats. A sample of gasoline caused light hydrocarbon nephropathy and the LOEL for this lesion was 500 mg/kg. This finding is specific to the male rat and is not relevant to human health.
Justification for selection of repeated dose toxicity inhalation - systemic effects endpoint:
One of 6 studies investigating repeat dose toxicity following inhalation exposure for periods up to 2 yrs. The only consistent effect was alpha 2u nephropathy in male rats, an effect which is not relevant for human health.
Justification for selection of repeated dose toxicity dermal - systemic effects endpoint:
Chronic dermal mouse study. No systemic toxicity or carcinogenic effect reported
Justification for selection of repeated dose toxicity dermal - local effects endpoint:
chronic dermal application study. Skin irritation only at dose 0.05 mL/kg, equivalent to 0.038 mg/kg bw/day.
Justification for classification or non-classification
Many of the studies described in this section followed regulatory guidelines and many have been published in the scientific literature. The data are sufficient for regulatory purposes, no additional testing is necessary. According to EU CLP regulation (EC No. 1272/2008), the classification for systemic toxicity is not warranted.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.