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EC number: 209-421-6 | CAS number: 578-36-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- Experimental test result performed according to the guideline.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Principles of method if other than guideline:
- Acute Immobilization study of sodium salicylate on Daphnia magna in a Semi-Static System for 48 hrs. Test performed according to the OECD guideline 202.
- GLP compliance:
- not specified
- Remarks:
- Test conducted originally for other purposes than REACH and thus conducted as per the OECD guidelines only.
Test material
- Reference substance name:
- Sodium salicylate
- EC Number:
- 200-198-0
- EC Name:
- Sodium salicylate
- Cas Number:
- 54-21-7
- Molecular formula:
- C7H6O3.Na
- IUPAC Name:
- sodium salicylate
- Test material form:
- solid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report):sodium salicylate- Molecular formula (if other than submission substance):C7H6O3.Na- Molecular weight (if other than submission substance): 160.1035- Substance type: organic- Physical state: solid- Name of test material (as cited in study report):sodium salicylate- Molecular formula (if other than submission substance):C7H6O3.Na- Molecular weight (if other than submission substance): 160.1035- Substance type: organic- Physical state: solid
Sampling and analysis
- Analytical monitoring:
- not required
- Remarks:
- As the test chemical was stable
Test solutions
- Vehicle:
- no
- Details on test solutions:
- The test substance was soluble in water. Therefore, the stock solution was prepared by dissolving 100 mg of the test substance in 100 ml of ADaM’s media and from this stock, further test solution was prepared for achieving test concentrations of 100 mg/L, respectively. ADaM’s media is used, prepared in MiliQ water.
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- - Common name: Water flea- Source: Own breeding of daphnia magna- Food: No feeding after hatching
Study design
- Test type:
- semi-static
- Water media type:
- freshwater
- Total exposure duration:
- 48 h
- Post exposure observation period:
- 24 and 48 hrs
Test conditions
- Hardness:
- 145.5 mg of CaCO3
- Test temperature:
- 20±2 °C
- pH:
- 7.3
- Details on test conditions:
- TEST SYSTEM - Test vessel: Glass beaker - Aeration: No aeration during experiment - Material, size, headspace, fill volume: 25 ml of glass beaker filled with 20 ml media having headspace of 5 ml - No. of organisms per vessel: 10 daphnids OTHER TEST CONDITIONS - Photoperiod:16 hours light and 8 hours dark
- Reference substance (positive control):
- not specified
Results and discussion
Effect concentrations
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: Other details not known
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Remarks:
- 1. In the control, including the control containing the solubilising agent, not more that 10 percent of the daphnids should have been immobilized. 2. The dissolved oxygen concentration at the end of the test should be 3 mg/l in control and test vessels
- Conclusions:
- Based on nominal concentrations, experimental median effective Concentrations [EC-50 (48 h)] for test chemical on test daphnia was determine to be > 100 mg/L.
- Executive summary:
Daphnia sp., Acute Immobilization Test according to OECD Guideline 203 was conducted for test chemical sodium salicylate. The test substance was soluble in water. Therefore, the stock solution was prepared by dissolving 100 mg of the test substance in 100 ml of ADaM’s media and from this stock, further test solution was prepared for achieving test concentrations of 100 mg/L, respectively. ADaM’s media is used, prepared in MiliQ water and test Daphnia magna were exposed to these concentration for 48 hours. Test conducted under the semi-static system in which 25 ml of glass beaker filled with 20 ml media having headspace of 5 ml were used. The median effect concentration (EC50) for test chemical on Daphnia magna in a 48 hours study on the basis of immobilization effect was determine to be > 100 mg/l. Test consider to be valid as fullfills all the criteria as per standards. Firstly In the control, including the control containing the solubilising agent, not more that 10 percent of the daphnids should have been immobilized. Secondly the dissolved oxygen concentration at the end of the test should be 3 mg/l in control and test vesselsBased on the EC50, it can be consider that the chemical was nontoxic and can be consider to be not classified as per the CLP classification criteria.
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