Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
Under the conditions of the test, oxygen consumption was not significantly inhibited at any of the concentrations tested. 3 hour EC50 > 1000 mg/L, NOEC 1000 mg/L, OECD 209, Roulstone 2013.
Key value for chemical safety assessment
- EC10 or NOEC for microorganisms:
- 1 000 mg/L
Additional information
The toxicity of the test material to microorganisms was determined in an activated sludge respiration inhibition test (carbon and ammonium oxidation) test performed under GLP conditions and in accordance with the standardised guidelines OECD 209.
Activated sewage sludge was exposed to an aqueous dispersion of the test material at concentrations of 10, 100 and 1000 mg/L (3 replicates of the 1000 mg/L test concentration) for a period of 3 hours at a temperature of 20 ± 2 °C with the addition of a synthetic sewage as a respiratory substrate. The rate of respiration was determined after 3 hours contact time and compared to data for the control and a reference item, 3,5-dichlorophenol.
Under the conditions of the test, oxygen consumption was not significantly inhibited at any of the concentrations tested. Since no significant toxic effects were shown the 3 hour EC50 is > 1000 mg/L and the NOEC is 1000 mg/L.
This key study was performed in line with GLP and accepted standardised guidelines with a high standard of reporting. The study was assigned a reliability score of 1 in accordance with the criteria outlined by Klimisch (1997) and considered suitable for assessment as an accurate reflection of the test material.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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