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EC number: 482-200-1 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
HPCTP is not classified to Skin irritation/corrosion and Eye irritation.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- Adopted: 28, July, 2015
- Qualifier:
- according to guideline
- Guideline:
- other: Testing Guidelines for Studies of Chemicals
- Version / remarks:
- Notification No. 2018-12, issued by the National Institute of Environmental Research, Republic of Korea on 9, April, 2018
- GLP compliance:
- yes
- Specific details on test material used for the study:
- Lot No. 180705
Purity: 99.08%
Appearance: White crystal
Storage condition: Room temperature - Species:
- rabbit
- Details on test animals or test system and environmental conditions:
- Species: New-Zealand white-Rabbit
Sex, number and body weight range (on administration): Males, 3 rabbits, 2.334-2.574 kg
Temperature: 17.0-23.2 oC(average: 19.5 oC)
Relative humidity: 30.0-70.0%(average:44.5%)
Air changes: 10-15 times/hour
Lighting: 12 hour light/dark cycle
Intensity of illumination: 150-300 Lux - Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- 0.5g
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 3 days
- Number of animals:
- 3
- Details on study design:
- Initial test were performed with one animal. The test item was applied to the animal three times in sequence. When ovserving the first three minutes and one hour after the applicaiton was do not observed skin irritation. Applied to the other parts of the third for 4 hours the skin reactions were evaluated scores. Since corrosive effect was not observed in the initial test, two additional animals were used for the confirmatory test. Skin reactions of each animal were evaluated applying 4 hours. Also the set control region does not apply the test item in the same animal.
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- HPCTP does not belong to the category planned in this study. Therefore test item was determined to "Not classified".
- Executive summary:
This study was conducted to evaluate the dermial irritant and/or corrosive response of the test item, Phenoxycycloposphazene. A total of 3 rabbits was treated with test item, and the skin reaction was observed for a maximunm of 3 day.
The test results are shown below.
1) Deaths and abnormal symptoms by test item were not observed.
2) Change of body weight by test item was not observed.
3) In the initial test, corrosive response was not observed.
4) In the initial and confirmatory test, the mean score of the three animals was 0.0, and the mean score of the two high-score animals among the three animals was 0.0.
5) Skin irritation by the test item lasted for up to 3 days.
6) Other reaction by the test item was not observed.
According to the above results, test item, Phenoxycycloposphazene does not belong to the category planned in this study. Therefore test item was determined to "Not classified".
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 438 (Isolated Chicken Eye Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage)
- Version / remarks:
- 25 June 2018
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- Batch/Lot number: 190202
Description: White or light yellow crystal
Purity: 99.53%
Expiry date: 31 January 2021
Storage conditions: Controlled room temperature (15-25o
C, ≤70% relative
humidity)
Safety precautions: Routine safety precautions (lab coat, gloves, safety glasses,
face mask) for unknown materials were applied to assure
personnel health and safety. - Species:
- chicken
- Strain:
- other: ROSS 308
- Details on test animals or tissues and environmental conditions:
- Chicken heads were collected after slaughter in a commercial abattoir from chickens (approximately 7 weeks old) which are used for human consumption. Heads were collected by a slaughter house technician and heads transported to Citoxlab Hungary
Ltd. at ambient temperature at the earliest convenience. After collection, the heads were inspected for appropriate quality and wrapped with tissue paper moistened with saline, then placed in a plastic box which was closed (4-5 heads per box). The heads were received at Citoxlab Hungary Ltd. and processed
within 2 hours of collection in each experiment. - Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent positive control
- yes, concurrent negative control
- Amount / concentration applied:
- 30 mg of the powdered test item
- Duration of treatment / exposure:
- In each experiment, 30 mg of the powdered test item was applied onto the entire surface of the cornea attempting to cover the cornea surface uniformly with the test item, taking care not to damage or touch the cornea. In each experiment, negative control eye was treated with 30 µL of physiological saline; positive control eyes were treated with 30 mg powdered Imidazole. One eye was treated with physiological saline, three eyes with the powdered test item and another three with powdered Imidazole in each experiment.
- Duration of post- treatment incubation (in vitro):
- The time of application was noted, then after an exposure period of 10 seconds from the end of the application the cornea surface was rinsed thoroughly with 20 mL physiological saline solution at ambient temperature, taking care not to damage the cornea but attempting to remove all residual test material if possible. Additional gentle rinsing (one or three times with 20 mL saline) was performed at each time point of both experiments when the test item or positive control material remaining on the cornea was observed.
- Number of animals or in vitro replicates:
- Experiment I and Experiment II
- Details on study design:
- In the first experiment, the test item was stuck on all cornea surfaces after the posttreatment rinse. One cornea surface (1/3) was cleared at 30 minutes, one cornea surface (1/3) at 75 minutes and the third cornea surface (1/3) was cleared at 120 minutes after the post-treatment rinse. In the second experiment, the test item was stuck on two cornea surfaces (2/3) after the post-treatment rinse. One cornea surface (1/3) was cleared at 30 minutes, the other cornea surface (1/3) was cleared at 120 minutes after the post-treatment rinse. In each experiment, positive control material was stuck on all cornea surfaces after the post-treatment rinse, the cornea surfaces (3/3) were not cleared at 240 minutes after the post-treatment rinse.
- Irritation parameter:
- percent corneal swelling
- Run / experiment:
- Experiment I
- Value:
- ca. 0
- Vehicle controls validity:
- valid
- Negative controls validity:
- valid
- Positive controls validity:
- valid
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- cornea opacity score
- Run / experiment:
- Experiment I
- Value:
- ca. 0.17
- Vehicle controls validity:
- valid
- Negative controls validity:
- valid
- Positive controls validity:
- valid
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- fluorescein retention score
- Run / experiment:
- Experiment I
- Value:
- ca. 0.17
- Vehicle controls validity:
- valid
- Negative controls validity:
- valid
- Positive controls validity:
- valid
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- percent corneal swelling
- Run / experiment:
- Experiment II
- Value:
- ca. 0
- Vehicle controls validity:
- valid
- Negative controls validity:
- valid
- Positive controls validity:
- valid
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- cornea opacity score
- Run / experiment:
- Experiment II
- Value:
- ca. 0
- Vehicle controls validity:
- valid
- Negative controls validity:
- valid
- Positive controls validity:
- valid
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- fluorescein retention score
- Run / experiment:
- Experiment II
- Value:
- ca. 0.17
- Vehicle controls validity:
- valid
- Negative controls validity:
- valid
- Positive controls validity:
- valid
- Remarks on result:
- no indication of irritation
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Based on these in vitro eye irritation assays in isolated chicken eyes withHPC TP, the test item was non-irritant, UN GHS Classification: No Category.
- Executive summary:
An in vitro eye irritation study of the test item was performed in isolated chicken’s eyes. The irritation effects of the test item were evaluated according to the OECD No. 438 guideline (25 June 2018). In each experiment after the zero reference measurements, the eye was held in horizontal position and 30 mg powdered test item was applied onto the centre of the cornea in such a way that the entire surface of the cornea was covered. After 10 seconds, the surface was rinsed with physiological saline. Positive control eyes were treated with 30 mg powdered Imidazole. The negative control eye was treated with 30 µL of physiological saline (0.9% (w/v) NaCl solution). In each experiment, three test item treated eyes, three positive control treated eyes and one negative control treated eye were examined. The results from all eyes used in the study met the quality control standards. The negative control and positive control results were within the historical control data range in each experiment. Thus, the study was considered to be valid. Experiment I: No corneal swelling was observed during the four-hour observation period on test item treated eyes. Minimal cornea opacity change and fluorescein retention change was observed on all three eyes. Test item was stuck on all cornea surfaces after the post-treatment rinse. One cornea surface (1/3) was cleared at 30 minutes, one cornea surface (1/3) at 75 minutes and the third cornea surface (1/3) was cleared at 120 minutes after the post-treatment rinse. Experiment II: No corneal swelling was observed during the four-hour observation period on test item treated eyes. No cornea opacity change was observed on all three eyes. Minimal fluorescein retention change was noted on all three eyes. Test item was stuck on two cornea surfaces (2/3) after the post-treatment rinse. One cornea surface (1/3) was cleared at 30 minutes, the other cornea surface (2/3) was cleared at 120 minutes after the post-treatment rinse. Based on these in vitro eye irritation assays in isolated chicken eyes with HPCTP, the test item was non-irritant, UN GHS Classification: No Category.
Reference
The results from all eyes used met the quality control standards. The negative control and positive control results were within the historical data range in each experiment. This study was considered to be valid.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
Based on the results of Skin irritation and Eye irritation studies, no adverse effect was observed.
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