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EC number: 500-013-6 | CAS number: 9004-78-8 1 - 2.5 moles ethoxylated
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 10th October 2019- 22nd October 2019
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- no
- Type of method:
- flask method
- Water solubility:
- 29 695.094 mg/L
- Conc. based on:
- test mat. (dissolved fraction)
- Incubation duration:
- 24 h
- Temp.:
- 20.6 °C
- pH:
- 5
- Water solubility:
- 29 756.967 mg/L
- Conc. based on:
- test mat. (dissolved fraction)
- Incubation duration:
- 48 h
- Temp.:
- 20.8 °C
- pH:
- 5
- Water solubility:
- 30 311.568 mg/L
- Conc. based on:
- test mat. (dissolved fraction)
- Incubation duration:
- 72 h
- Temp.:
- 20.9 °C
- pH:
- 6
- Key result
- Water solubility:
- 29 921.209 mg/L
- Conc. based on:
- test mat. (dissolved fraction)
- Temp.:
- 20.8 °C
- pH:
- >= 5 - <= 6
- Details on results:
- Phenol, ethoxylated gave a mean result for solubility of 29921.209 mg/l with no evidence of chemical instability, due to the standards that were injected every run. The protocol states that the percentage difference between replicates must be ≤15% and samples were within this range, showing a percentage of using the formula : [ (Average Concentration 2 – Average Concentration 3)/ Average Conc. 2-3 ] * 100 .
- Conclusions:
- The water solubility of Phenol, ethoxylated was determined to be 29,921.209 mg/L at 20.8 ± 0.2 °C.
- Executive summary:
The water solubility of Phenol, ethoxylated was determined by the flask method, using a procedure designed to be compatible with Method A.6 Water Solubility of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 105 of the OECD Guidelines for Testing of Chemicals, 27 July 1995. A preliminary test was performed in order to select the appropriate method and to determine that volume of water in which complete dissolution of the sample occurs. In a stepwise procedure, increasing volumes of water were added at room temperature to 0.1 g of the liquid sample in a 10 mL glass-stoppered measuring cylinder. After each addition of water, the mixture was shaken for 10 minutes and checked for any undissolved parts of the sample, visual observations were made. After the addition of 0.1 mL of water, the sample was immiscible and it showed no solubility until 10 mL were added. Therefore, 10m mL was the lowest volume of water that could have been added to dissolve the sample in water clearly. Based on the result of the preliminary test, the solubility of the material was estimated to be approximately between 10 g/L (10,000 mg/L) and 50 g/L (50,000 mg/L), therefore the shake flask method was chosen for the definitive test. Three identical 100 mL volumetric flasks were prepared by addition of the test sample (5.01 g, 5.00 g, 5.00 g) and by adding 100 mL of water, the contents were agitated. These flasks were tightly stoppered and incubated in a water bath (29.7°C) whilst being constantly stirred. After 24 hours the first sample was removed from the water bath and left equilibrating at 20.6°C. Then the test was centrifuged and pipetted into a vial ready for the analysis. After 48 hours the second sample was removed and followed the same procedure (20.8°C); likewise, for the 72 hours flask (20.9°C). The samples were run to determine the dissolved concentration of Phenol, ethoxylated in the eluent of the solubility test solutions on an HPLC. Phenol, ethoxylated gave a mean result for solubility of 29,921.209 mg/L with no evidence of chemical instability, due to the standards that were injected every run. The protocol states that the percentage difference between replicates must be ≤15% and samples were within this range. Therefore, the water solubility of Phenol, ethoxylated was determined to be 29,921.209 mg/L at 20.8 ± 0.2 °C.
Reference
Table 2: Average solubility of the sample (mg/l):
Flask | Concentration (mg/l) | Difference % (2 -1,3 -2) | Solubility of the sample (mg/l) Average |
1 | 29695.094 | # | |
2 | 29756.967 | 0.21% | 29921.209 |
3 | 30311.568 | 1.85% |
Table 3: pH and Incubation details
Samples | pH | Temp°C (Water bath) | Temp °C (Lab) |
1 | 5.0 | 29.1 | 20.6 |
2 | 5.0 | 30.0 | 20.8 |
3 | 6.0 | 29.5 | 20.9 |
The Water bath in the 3 days showed a temperature of 29.5±0.5°C and the laboratory where the samples were equilibrated a temperature of 20.8±0.2°C.
Description of key information
The water solubility of Phenol, ethoxylated was determined to be 29921.209 mg/L at 20.8 ± 0.2 °C.
Key value for chemical safety assessment
- Water solubility:
- 29 921.209 mg/L
- at the temperature of:
- 20.8 °C
Additional information
The water solubility of Phenol, ethoxylated was determined by the flask method, using a procedure designed to be compatible with Method A.6 Water Solubility of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 105 of the OECD Guidelines for Testing of Chemicals, 27 July 1995. A preliminary test was performed in order to select the appropriate method and to determine that volume of water in which complete dissolution of the sample occurs. In a stepwise procedure, increasing volumes of water were added at room temperature to 0.1g of the liquid sample in a 10ml glass-stoppered measuring cylinder. After each addition of water, the mixture was shaken for 10 minutes and checked for any undissolved parts of the sample, visual observations were made. After the addition of 0.1ml of water, the sample was immiscible and it showed no solubility until 10ml were added. Therefore, 10ml was the lowest volume of water that could have been added to dissolve the sample in water clearly. Based on the result of the preliminary test, the solubility of the material was estimated to be approximately between 10g/l (10000mg/l) and 50g/l (50000mg/l), therefore the shake flask method was chosen for the definitive test. Three identical 100ml volumetric flasks were prepared by addition of the test sample (5.01g, 5.00g, 5.00g) and by adding 100ml of water, the contents were agitated. These flasks were tightly stoppered and incubated in a water bath (29.7ºC) whilst being constantly stirred. After 24 hours the first sample was removed from the water bath and left equilibrating at 20.6ºC. Then the test was centrifuged and pipetted into a vial ready for the analysis. After 48 hours the second sample was removed and followed the same procedure (20.8ºC); likewise, for the 72 hours flask (20.9ºC). The samples were run to determine the dissolved concentration of Phenol, ethoxylated in the eluent of the solubility test solutions on an HPLC. Phenol, ethoxylated gave a mean result for solubility of 29921.209 mg/l with no evidence of chemical instability, due to the standards that were injected every run. The protocol states that the percentage difference between replicates must be ≤15% and samples were within this range. Therefore, the water solubility of Phenol, ethoxylated was determined to be 29921.209mg/l at 20.8 ± 0.2 °C.
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