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Diss Factsheets
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EC number: 951-182-1 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- April 1973
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Study carried out prior to guideline and GLP
- GLP compliance:
- no
- Remarks:
- Study conducted prior to GLP
Test material
- Reference substance name:
- Diamino Trimethylphenylindane
- IUPAC Name:
- Diamino Trimethylphenylindane
- Test material form:
- solid: particulate/powder
- Details on test material:
- Purity:
97.6% (49.9% 6-4’ isomer, 47.7 5-4’ isomer; per Protocol)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Young albino rats of the Sprague-Dawlcy strain* were used as test animals. All animals were kept under observation for five days prior to experimental use, during which period they were checked for general physical health and suitability as test animals. The animals were housed in stock cages and were permitted a standard laboratory diet plus water ad libitum, except during the 16-hour period immediately prior to oral intubation when food was withheld.
Administration / exposure
- Route of administration:
- other: hypodermic syringe with ball tipped intubating needle
- Vehicle:
- corn oil
- Details on oral exposure:
- Initial screening was conducted in order to determine the general
level of toxicity of the test material. Selected groups of four albino rats
each (two males and two females) were administered the test material at
several dose levels. All doses were administered directly into the stomachs
of the r a t s using a hypodermic syringe equipped with a ball-tipped intubating
needle. - Doses:
- 400, 600, 900, 1350 mg/kg
- No. of animals per sex per dose:
- 2
- Control animals:
- no
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 600 mg/kg bw
- Based on:
- test mat.
- Mortality:
- See data table
- Clinical signs:
- other: 600 mg/kg dose level: Hypoactivity Ruffed fur Muscular weakness Salivation Lacrimation Prostration 900 mg/kg dose level: Hypoactivity Ruffed fur Muscular weakness Salivation Lacrimation Prostration Hypothermia Shallow breathing Emaciation 1350 dose leve
Any other information on results incl. tables
Mortality and Body Weight Data
Dose (mg/kg) |
Animal Number and Sex | Individual Body Weight Day 0 |
Individual Body Weight Day 14 |
Number Dead/Number tested | Precent dead |
400 | 1M |
212 | 310 | 0/4 | 0 |
2M | 201 | 308 | |||
3F | 179 | 225 | |||
4F | 167 | 208 | |||
600 | 5M | 208 | (2days) | 3/4 | 75 |
6M | 205 | (2days) | |||
7M | 174 | (2 days) | |||
8F | 183 | 224 | |||
900 | 9M | 197 | (5 days) | 3/4 | 75 |
10M | 204 | (1 day) | |||
11F | 152 | 187 | |||
12F | 173 | (1 day) | |||
1350 | 13M | 203 | (6 -22 hours) | 4/4 | 100 |
14M | 217 | (1day) | |||
15F | 161 | (6 -22 hours) | |||
16F | 167 | (6 -22 hours) |
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- an LD50 of 600 mg/kg was calculated for acute oral toxicity using the techniques of Weil and Thompson.
- Executive summary:
Young albino rats of the Sprague-Dawlcy strain* were used as
test animals. All animals were kept under observation for five days prior
to experimental use, during which period they were checked for general
physical health and suitability as test animals. The animals were housed in
stock cages and were permitted a standard laboratory diet plus water ad
libitum, except during the 16-hour period immediately prior to oral intubation
when food was withheld.
Initial screening was conducted in order to determine the general
level of toxicity of the test material. Selected groups of four albino rats
each (two males and two females) were administered the test material at
several dose levels. All doses were administered directly into the stomachs
of the r a t s using a hypodermic syringe equipped with a ball-tipped intubating
needle.
After oral administration of the test material, the rats were housed
individually in suspended, wire-mesh cages and observed for the following
14 days. Initial and final body weights, mortalities, and reactions were r e corded.
A necropsy was conducted on any animal which died during the
study and on all animals sacrificed at the end of the 14-day observation
period.
At the end of the observation period, the acute oral median lethal
dose (LD50) of 600 mg/kg was calculated.
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