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EC number: 818-416-3 | CAS number: 1438425-69-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Melting point / freezing point
Administrative data
Link to relevant study record(s)
- Endpoint:
- melting point/freezing point
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- September 04, 2019 to September 12, 2019
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 102 (Melting point / Melting Range)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.1 (Melting / Freezing Temperature)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- differential scanning calorimetry
- Remarks:
- and capillary method
- Key result
- Melting / freezing pt.:
- > 135 °C
- Decomposition:
- yes
- Remarks:
- melted under decomposition starting at 135 °C
- Decomp. temp.:
- > 135 °C
- Executive summary:
The test item BAY 1021189 (Vericiguat) DMSO-Solvat melted under decomposition starting at 135 °C. The decomposition (bubble formation and mass loss) could have been caused by an evaporation of the DMSO, that is included in the test item as solvate.
Reference
Individual results
Melting point / melting range: Differential scanning calorimetry
Two DSC measurements in aluminium crucibles with a hole showed two endothermal effects in the temperature range of 70 – 140 °C and 160 – 260 °C. Additionally a multistage exothermal effect in the temperature range of 320 – 460 °C was observed. After the measurement the test item was a black residue. The mass loss after the DSC measurement amounted to 50 % and 48 %, respectively.
Two additional DSC measurements were performed in order to clarify the melting. The DSC measurement in an aluminium crucible with a hole up to 150 °C showed an endothermal effect in the temperature range of 80 – 140 °C, but the test item appeared unchanged after the measurement (mass loss 1 %). Whereas the DSC measurement in an aluminium crucible with a hole up to 240 °C showed two endothermal effects in the temperature range of 90 – 135 °C and 135 – 240 °C and the test item changed into a yellow solidified melt (mass loss: 25 %).
The results of the DSC measurements are summarized in Table 1.
Table 1: DSC measurements
Ident No. | Test item / mg | Starting temperature / °C | Final test temperature / °C | Temperature range / °C | Crucible | Observations after the measurement |
38800 | 10.84 | 25 | 500 | 70 – 135 (endothermal) 160 – 260 (endothermal) 320 – 460 (multistage exothermal) |
Aluminium with a hole | Test item was a black residue; mass loss: 50 % |
38801 | 6.90 | 25 | 500 | 80 – 140 (endothermal) 160 – 250 (endothermal) 320 – 460 (multistage exothermal) |
Aluminium with a hole | Test item was a black residue; mass loss: 48 % |
38802 | 10.42 | 25 | 150 | 80 – 140 (endothermal) | Aluminium with a hole | Test item was a light yellow solid; mass loss: 1 % |
38803 | 9.23 | 25 | 240 | 90 – 135 (endothermal) 135 – 240 (endothermal) |
Aluminium with a hole | Test item was a yellow solidified melt; mass loss: 25 % |
Due to these results, it was assumed that the second peak in the temperature range of 135 – 240 °C belonged to the melting. Because of a mass loss of 25 % after the DSC measurement up to 240 °C additional measurements with the capillary method were performed in order to clarify the melting behavior.
Melting point / melting range: capillary tube in a metal block
Two measurements with the capillary method were performed to clarify the results of the DSC measurements. Since the measurements were performed only as a verifying screening a high heating rate of 10 K/min was chosen and therefore the absolute temperature values derived with the capillary method are not as accurate as the DSC results. For both measurements the filling height of the test item was approximately 5 mm. The results are summarized in Table 2.
Table 2: Results of the capillary method
No. | Set point / °C | Heating rate / K/min | End point / °C | Remarks |
1 | 100 | 10 | 250 | 100 °C: Test item appeared unchanged Approx. 202 °C: Test item changed partly into a light-yellow liquid (start of melting) Approx. 210 °C: Bubble formation (test item rose partly up in the melting tube) Approx. 217 °C: Test item was completely molten into a yellow liquid |
2 | 100 | 10 | 250 | 100 °C: test item appeared unchanged Approx. 120 °C: Test item started to soften Approx. 120 °C to 203 °C: Continuous softening of the test item Approx. 203 °C: Test item changed partly into a light-yellow liquid (start of melting) Approx. 211 °C: Bubble formation (test item rose partly up in the melting tube) Approx. 216 °C: Test item was completely molten into a yellow liquid. |
Under consideration of the results from the DSC measurements and the capillary method it was concluded that the test item melted under decomposition starting at 135 °C. The decomposition (bubble formation and mass loss) could have been caused by an evaporation of the DMSO (Dimethyl sulfoxide, boiling point: 189 °C ), that is included in the test item as solvate (Test item: BAY 1021189 (Vericiguat) DMSO-Solvat).
Description of key information
The test item BAY 1021189 (Vericiguat) DMSO-Solvat melted under decomposition starting at 135 °C. The decomposition (bubble formation and mass loss) could have been caused by an evaporation of the DMSO, that is included in the test item as solvate.
Key value for chemical safety assessment
Additional information
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