Registration Dossier
Registration Dossier
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EC number: 283-298-7 | CAS number: 84604-20-6 Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Silybum marianum, Compositae.
Vapour pressure
Administrative data
Link to relevant study record(s)
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- December 10, 2018 - December 17, 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 104 (Vapour Pressure Curve)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.4 (Vapour Pressure)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- effusion method: isothermal thermogravimetry
- Key result
- Temp.:
- 20 °C
- Vapour pressure:
- 0.004 Pa
- Conclusions:
- The isothermal thermogravimetrical effusion method was applied for the determination of the vapour pressure of Extract of Chardon marie without support.
A value of the vapour pressure of the test item was determined using the data obtained between 130 °C and 160 °C. The vapour pressure of the test item was estimated to be 4.20 x 10-3 Pa at 20 °C.
Reference
The evaluation of the vapour pressure was done with the reproducible weight loss values above > 1 µg/min in the temperature range between 130 °C to 160 °C.
Plot of log VT of the test item as function of the reciprocal temperatures gave the coefficient of correlation (R2) 0.9995.
The regression line of log PT as a function of log VT used for calibration. The coefficient of correlation (R2) was 0.9825. The resulting equation was:
log PT = 4.3781 + 1.0022 x log vT
Inserting the equation for log VT above, the following equation for the tempera-ture dependence of the vapour pressure of the test item is obtained:
log PT = (C + D x (a x 1000/T + b) = C + (Dxb) + (D x a x 1000) )/ T
(where: a = -3.8344, b = 6.3469, C = 4.3781 and D = 1.0022)
With this equation, a following vapour pressure results were obtained:
4.20 x 10-3 Pa at 20 °C.
Description of key information
The vapour pressure of the test item was estimated to be 4.20 x 10-3 Pa at 20 °C.
Key value for chemical safety assessment
- Vapour pressure:
- 0.004 Pa
- at the temperature of:
- 20 °C
Additional information
The isothermal thermogravimetrical effusion method was applied for the determination of the vapour pressure of Extract of Chardon marie without support.
A value of the vapour pressure of the test item was determined using the data obtained between 130 °C and 160 °C. The vapour pressure of the test item was estimated to be 4.20 x 10-3 Pa at 20 °C.
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