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Diss Factsheets
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EC number: 238-056-5 | CAS number: 14205-39-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1983
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Single administration of seven concentrations with an application volume of 20 ml/kg to fasted rats (5 males and 5 females) via stomach tube with an observation period of 14 days
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Test material form:
- solid: crystalline
- Details on test material:
- 3-Aminocrotonsäuremethylester, solid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
Fasted (no food 16 h before and 4 h after application)
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: Lutrol (PEG 400)
- Doses:
- 1300, 1500, 1800, 1900, 2000, 2500 and 3100 mg/kg with an application volume of 20 ml/kg
- No. of animals per sex per dose:
- 10 ( 5 males and 5 females)
- Control animals:
- no
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 760 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 1 610 - <= 1 910
- Mortality:
- All deaths occurred on the first day after administration.
- Clinical signs:
- other: No symptoms at dose 1300 mg/kg. All animals at dose 1500 mg/kg and above symptomatic (e.g. reduced general condition, cyanosis, ventral or lateral position, narcosis, dyspnea). Clinical signs occurred after 5 to 10 min after administration, on day 3 all
- Gross pathology:
- Bleedings in the mucous membrane of the stomach.
- Other findings:
- No abnormal findings seen at final necropsy
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- The acute oral LD50 was 1760 mg/kg.
- Executive summary:
The acute oral toxicity of methyl 3 -aminocrotonate was determined in fasted male and female rats after single administration of seven concentrations with an application volume of 20 ml/kg via stomach tube with an observation period of 14 d. The acute oral LD50 was 1760 mg/kg.
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