Registration Dossier
Registration Dossier
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EC number: 900-600-0 | CAS number: -
Endpoint summary
Administrative data
Description of key information
Based on a weight of evidence approach on data available on each constituents, the multiconstituent substance (Flux1) is considered as not bioaccumulable and does not fulfil B criterion of PBT assessment (all BCF<13).
Additional information
No experimental study was conducted on the multiconstituent substance (Flux1). Instead, a constituent-based, Weight-of-Evidence approach, was performed.
The three major constituents were targeted, representing ca 95% of a typical composition (carbon tetrachloride (CAS n° 56 -23 -5), 1,2 -Dichloroethane (CAS n°107 -06 -2) and chloroform (CAS n° 67-66 -3)). Numerous published data were available, and a single consensus value was selected for each, from a reliable source.
No average key value was derived for the multiconstituent substance: as the Risk Assessment is conducted per constituent, individual values are the key data.
Bioconcentration factors (BCF) for carbon tetrachloride (CTC) have been measured following the OECD 305C (MITI Japan, 1992). BCF values of 3.2 - 7.4 and 3.8 - 11 were determined for Cyprinus carpio with a test concentration of 1 ppb and 10 ppb (µg/L) of CTC, respectively. These results showed that CTC is not bioaccumulable.
A study to determine the bioconcentration of 1,2 -dichloroethane in bluegill sunfish (Lepomis macrochirus) was conducted with the nominal concentration of 100 µg test item/L under flow-through conditions using 14C labelled material (Barrows et al. 1980). An untreated control was run in parallel. The uptake phase was 14 days, the depuration phase lasted 7 days. Fish and water samples were taken at the same time and analysed for radioactivity and 1,2 -dichlorethane to derive the uptake and depuration constants as well as the bioconcentration factor in the state of equilibrium between uptake and elimination. As a total result of the study, the BCF of 1,2-dichloroethane can be stated with BCF = 2 and it is not considered as bioacccumulable.
A bioconcentration assay of chloroform was carried out using carp (Cyprinus carpio) in a continuous flow-through system in accordance with OECD Guideline No. 305 (MITI Japan, 1992). Fish were exposed to a nominal chloroform concentration of 0.1 mg/L for 42 days. Bioconcentration factors were found to range from 4.1 to 13. Chloroform is not considered as bioaccumulable.
Based on a weight of evidence approach on data available on each constituents, the multiconstituent substance (Flux1) is considered as not bioaccumulable and does not fulfill B criteria of PBT assessment.
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