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EC number: 234-232-0 | CAS number: 10605-21-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- May 1988
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 009
- Report date:
- 2009
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 201 (Alga, Growth Inhibition Test)
- GLP compliance:
- no
Test material
- Reference substance name:
- Carbendazim
- EC Number:
- 234-232-0
- EC Name:
- Carbendazim
- Cas Number:
- 10605-21-7
- Molecular formula:
- C9H9N3O2
- IUPAC Name:
- carbendazim
Constituent 1
Test solutions
- Vehicle:
- no
- Details on test solutions:
- Five test concentrations plus one control were tested in triplicate. Rifty ml of algal pre-culture were added to 50 ml of sterile nutrient medium containing the appropriate amount of the test substance. All test vessels were loosely stoppered and placed at random in an orbital incubator. The cultures were incubated, without media renewal, for 120 hrs under continuous illuminations of app. 700 lux. This level of illumination was necessay to ensure satisfactory growth at 72 h in compliance with OECD guideline.
Test organisms
- Test organisms (species):
- Raphidocelis subcapitata (previous names: Pseudokirchneriella subcapitata, Selenastrum capricornutum)
Study design
- Total exposure duration:
- 72 h
Test conditions
- Test temperature:
- 24 +/- 1 °C
- pH:
- Initial pH of the nutrient medium was 7.5.
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 72 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.5 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- 1.3 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- biomass
- Details on results:
- There were no abnormalities detected in controls or test cultures at 0.05 and 1.0 mg/l. Test concentrations of 2.0, 4.0 and 8.0 mg/l appeared to be clumped. Aliquots (0.5 ml) were removed from each replicate culture at the lowest test concentrations resulting in severe inhibition (8.0 mg/l) and the replicate pooled. One hundred ml of fresh sterile nutrient medium was added to ensure that the test concentration was reduced to below the inhibition lever. The subcultures were incubated at 24°C for 9 days. regrowth occurred in the control but not test culture after a period of 9 day demonstrating that the test substance was algicidal.
Applicant's summary and conclusion
- Conclusions:
- The EbC50(72 hr) was calculated as 1.3 mg/l. Lack of regrowth of inhibited cultures indicated that the test substance is algicidal. The NOEL was determined to be 0.5 mg carbendazim/l under test conditions.
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