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EC number: 204-524-2 | CAS number: 122-14-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 21 January 1985 - 20 March 1986
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- traditional method
- Limit test:
- no
Test material
- Reference substance name:
- Fenitrothion
- EC Number:
- 204-524-2
- EC Name:
- Fenitrothion
- Cas Number:
- 122-14-5
- Molecular formula:
- C9H12NO5PS
- IUPAC Name:
- O,O-dimethyl O-3-methyl-4-nitrophenyl phosphorothioate
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- Fenitrothion
Batch No.: 40805
Purity: 96.6%
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Nominal concentration of the test material in the chamber air (mg/m3)
Group I: vehicle only (vehicle control)
Group II: vehicle only (negative control)
Group III: 6.57
Group IV: 16.4
Group V: 65.7
Group VI: 1640
Group VII: 3280
Mean concentration measured (mg/m3)
Group III: 3.91
Group IV: 8.90
Group V: 38.2
Group VI: 1,010
Group VII: 2,210
Median aerodynamic diameter: 0.59 to 0.82 µm
Chamber air temperature: 28.4 to 30.8 °C
Relative humidity: 59.8 to 90.3 %
Administration / exposure
- Route of administration:
- inhalation: dust
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: corn oil
- Mass median aerodynamic diameter (MMAD):
- >= 0.59 - <= 0.82 µm
- Remark on MMAD/GSD:
- Particle size adequately small: in the respirable range
- Details on inhalation exposure:
- Fenitrothion was dissolved in corn oil and administered by inhalation of a test atmosphere containing dust generated from the test substance; single administration, 4-hour whole body exposure.
- Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Remarks on duration:
- Standard exposure period
- Concentrations:
- Mean measured concentrations were 3.91, 8.90, 38.2, 1010 and 2210 mg/m3.
- No. of animals per sex per dose:
- 20/sex: each group had a main group for general observation, body weight, cholinesterase activity and pathological examination, and a satellite group for assessment of cholinesterase activity only.
- Control animals:
- yes
- Remarks:
- Two control groups; control and non-exposed
- Details on study design:
- Fenitrothion was dissolved in corn oil and administered by inhalation of a test atmosphere containing dust generated from the test substance; single administration, 4-hour whole body exposure, two control groups (vehicle and negative controls) and five test groups of Sprague-Dawley rats. Each exposure group had a main group for general observation, body weight, cholinesterase activity and pathological examination, and a satellite group for assessment of cholinesterase activity only.
- Statistics:
- Not required
Results and discussion
- Preliminary study:
- Not reported
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 2 210 mg/m³ air (analytical)
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Mortality:
- One male exposed to 2210 mg/m3 died on Day 6. There were no further mortalities.
- Clinical signs:
- other: Irregular respiration, hyperpnoea, nasal discharge, muscular fibrillation, intermittent tremors, reduced spontaneous activity, lacrimation, salivation and urinary incontinence were observed in both sexes at >= 1010 mg/m3 and above. Males also showed exci
- Body weight:
- Slight transient reductions in body weight or weight gain was seen at >=1010 mg/m3.
- Gross pathology:
- Necropsy did not reveal any effects of treatment.
- Other findings:
- Inhibition of cholinesterase activity was observed 1-7 days after exposure. Plasma cholinesterase activity was reduced in males and females exposed to >=8.90 mg/m3; erythrocyte cholinesterase activity was reduced in males of groups exposed to >=1010 mg/m3 and in females exposed to >= 38.2 mg/m3. Brain cholinesterase activity was reduced in males and females exposed to >= 1010 mg/m3.
Any other information on results incl. tables
Summary of mortality
Exposure level
|
Males |
Females |
||
Cumulative Mortality |
Time of death |
Cumulative Mortality |
Time of death |
|
3.91 mg/m3 |
0 |
- |
0 |
- |
8.90 mg/m3 |
0 |
- |
0 |
- |
38.2 mg/m3 |
0 |
- |
0 |
- |
1010 mg/m3 |
0 |
- |
0 |
- |
2210 mg/m3 |
1 |
Day 6 (1) |
0 |
- |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The acute inhalation LC50 of fenitrothion was found to be >2.21 mg/L (reported to be the maximum attainable concentration). Classification for acute inhalation toxicity is not required according to CLP criteria.
- Executive summary:
The acute inhalation toxicity of fenitrothion was investigated in a study in the rat. Groups of Sprague-Dawley rats (20/sex) were exposed for four hours (whole body) to mean measured concentrations of 3.91, 8.90, 38.2, 1010 and 2210 mg/m3 (MMAD 0.59 -0.82 um). One male exposed to 2210 mg/m3 died on Day 6. There were no further mortalities. Irregular respiration, hyperpnoea, nasal discharge, muscular fibrillation, intermittent tremors, reduced spontaneous activity, lacrimation, salivation and urinary incontinence were observed in both sexes at >= 1010 mg/m3 and above. Males also showed excitation, tonic convulsion, ataxia and soft faeces. Signs of toxicity were observed from 30 minutes after the initiation of exposure and resolved within 9 days of exposure in surviving rats. Slight transient reductions in body weight or weight gain was seen at >=1010 mg/m3. Inhibition of cholinesterase activity was observed 1-7 days after exposure. Plasma cholinesterase activity was reduced in males and females exposed to >=8.90 mg/m3; erythrocyte cholinesterase activity was reduced in males of groups exposed to >=1010 mg/m3 and in females exposed to >= 38.2 mg/m3. Brain cholinesterase activity was reduced in males and females exposed to >= 1010 mg/m3. Gross necropsy did not reveal any effects of treatment. The acute inhalation LC50 of fenitrothion was found to be >2210 mg/m3 (>2.21 mg/L; reported to be the maximum attainable concentration). Classification for acute inhalation toxicity is not required according to CLP criteria.
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