Registration Dossier
Registration Dossier
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EC number: 481-830-4 | CAS number: 3687-22-7
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- other: SNIF
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
Data source
Referenceopen allclose all
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
- Year:
- 2 008
- Reference Type:
- other: SNIF#001-4.150-01
- Title:
- Unnamed
- Year:
- 2 008
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Annex V.
- GLP compliance:
- yes
Test material
Constituent 1
Test animals
- Species:
- other: Rabbit, New Zealand White
Test system
- Type of coverage:
- semiocclusive
- Vehicle:
- other: None.
- Duration of treatment / exposure:
- 4 h
- Number of animals:
- 3
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Remarks:
- (mean score 2)
- Time point:
- other: overall at 24, 48 and 72 h
- Score:
- 2.3
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Remarks:
- (mean score 3)
- Time point:
- other: overall at 24, 48 and 72 h
- Score:
- 3
- Irritation parameter:
- erythema score
- Max. score:
- 3
- Remarks on result:
- other: Max. duration: d; Max. value at end of observation period: 2 (related to all animals)
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Remarks:
- (mean score 1)
- Time point:
- other: overall at 24, 48 and 72 h
- Score:
- 1.3
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Remarks:
- (mean score 2)
- Time point:
- other: overall at 24, 48 and 72 h
- Score:
- 1.7
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Remarks:
- (mean score 3)
- Time point:
- other: overall at 24, 48 and 72 h
- Score:
- 1.3
- Irritation parameter:
- edema score
- Max. score:
- 2
- Remarks on result:
- other: Max. duration: d; Max. value at end of observation period: 1 (related to all animals)
- Irritant / corrosive response data:
- Reversibility of any observed effect: Changes not fully reversible within 15 days
- Other effects:
- After a 4-hour exposure (three animals), a yellow coloration
of the skin was observed throughout the observation period
in 2/3 animals and on day 1 only in the third animal. In 1/3
animals, the evaluation of erythema was masked by this
coloration from days 1 to 3.
A dryness of the skin was recorded in all the animals
between days 4 and 15. A brownish area was observed in 1/3
animals between days 4 and 6.
Applicant's summary and conclusion
- Interpretation of results:
- irritating
- Remarks:
- Migrated information
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