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EC number: 211-838-3 | CAS number: 700-13-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 26.02.2019 - 11.03.2019
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 019
- Report date:
- 2019
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 1995
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- GLP compliance:
- no
- Type of method:
- flask method
Test material
- Reference substance name:
- 2,3,5-trimethylhydroquinone
- EC Number:
- 211-838-3
- EC Name:
- 2,3,5-trimethylhydroquinone
- Cas Number:
- 700-13-0
- Molecular formula:
- C9H12O2
- IUPAC Name:
- 2,3,5-trimethylhydroquinone
- Test material form:
- solid: particulate/powder
Constituent 1
Results and discussion
Water solubility
- Key result
- Water solubility:
- 0.9 g/L
- Conc. based on:
- test mat. (dissolved fraction)
- Incubation duration:
- <= 72 h
- Temp.:
- 20 °C
- pH:
- < 7
Any other information on results incl. tables
For the main test three flasks were prepared with an amount of test item and water, and one flask only with water. After stirring and centrifugation the aqueous phases were dilutedwith acetonitrileand measured by means of HPLC. The solution of each flask has been measured twice. The values represented in the table are rounded values. The calculation was carried out with the original not rounded values.
After the stirring time the test solutions showed a change in colour to brownish and black undissolved particles could be observed inside the flasks. In its delivered state, the test item is an off-white powder, which does not contain any black particles. The change in colour and the formation of black particles may be caused by a reaction of the test item with water. Due to these observations, the following values have to be used with caution and a possible reaction of the test item with water should be further investigated.
Results of the flask method
Flask |
1a (72 h) |
2a (48 h) |
3a (24 h) |
4a (72 h) |
measured value [mg/L] |
42.10 / 42.77 |
41.48 / 41.57 |
45.19 / 45.82 |
0 / 0 |
aliquot of the flask [mL] |
0.05 |
0.05 |
0.05 |
0.05 |
total volume after dilution [mL] |
1 |
1 |
1 |
1 |
water solubility [g/L] |
0.84 / 0.86 |
0.83 / 0.83 |
0.90 / 092 |
0 / 0 |
average water solubility [g/L] |
0.85 |
0.83 |
0.91 |
0 |
mean value of the water solubility [g/L] |
0.86 |
0 |
||
standard deviation [g/L] |
0.04 |
-- |
||
relative standard deviation [%] |
4.8 |
-- |
To verify the accuracy of the analytical method freshly prepared standard solutions (prepared with the test item) were measured in between the samples of the flask method.
Measurements of standard solutions
Standard solution (nominal value [mg/L]) |
Measured value [mg/L] |
Repeatability [%] |
Ü1 (51.5) |
50.97 |
99.0 |
50.90 |
98.8 |
|
Ü2 (61.9) |
61.93 |
100.1 |
62.46 |
100.9 |
The recovery rate of the measured standard solutions was in the range from 98.8 % to 100.9%, which shows a good accuracy of the analytical method.
Applicant's summary and conclusion
- Conclusions:
- The water-solubility of trimethylhydroquinone was determined to be 0.9 g/L according to the flask method.
- Executive summary:
According to OECD Test Guideline 105 (1995) and Regulation EC No. 440/2008 Method A.6. the water solubility at 20°C of the test item 2,3,5-Trimethylhydroquinonewas determined to be:
cS = 0.9 g/L
RSD = 4.8 %
Due to the fact that the solution of the test item changed its colour to brownish and black particles could be observed inside the flasks after the stirring time, a reaction with water cannot be excluded and the stated value has to be used with caution. These observations should be further investigated.
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