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EC number: 701-216-4 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Indium-113m-Labeled Polyfunctional Phosphonates as Bone Imaging Agents
- Author:
- Subramanian G, McAfee JG, Rosenstreich M, Coco M.
- Year:
- 1 975
- Bibliographic source:
- J Nucl Med. 1975 Nov; 16(11):1080-4; http://jnm.snmjournals.org/content/16/11/1080.long
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- ¹¹³m-In-labelled DTPMP was injected intravenously to adult albino rabbits. One to three hours after injection the rabbits were imaged in the posterior projection with a scintillation camera. Organ distribution of radiolabel was determined after the animals were sacrificed from 1 to 4 hours after injection.
- GLP compliance:
- no
Test material
- Reference substance name:
- [[(phosphonomethyl)imino]bis[ethane-2,1-diylnitrilobis(methylene)]]tetrakisphosphonic acid
- EC Number:
- 239-931-4
- EC Name:
- [[(phosphonomethyl)imino]bis[ethane-2,1-diylnitrilobis(methylene)]]tetrakisphosphonic acid
- Cas Number:
- 15827-60-8
- Molecular formula:
- C9H28N3O15P5
- IUPAC Name:
- Diethylenetriaminepentakis(methylphosphonic acid)
- Test material form:
- not specified
Constituent 1
- Radiolabelling:
- yes
- Remarks:
- ¹¹³m-In and ⁸⁵Sr
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Details on species / strain selection:
- Albino
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 3.5 - 5 kg
- Age at study initiation: adult
Administration / exposure
- Route of administration:
- intravenous
- Details on exposure:
- PREPARATION OF DOSING SOLUTIONS: ¹¹³m-In or ¹¹¹In with 25-50 mg of the desired phosphonates in a volume of 4-5 ml. The pH was adjusted to 7.5-8.0 with dilute (0.1 N) sodium hydroxide or dilute (0.1 N) HCl as required since phosphonates salts dissolved in water exhibited high pH as expected and the initial pH of the mixture varied depending on the volume of the acidic indium solution. The preparation was sterilized by membrane filtration through 0.22-micron-size filters. The amount of free indium in the preparation was determined by paper electrophoresis.
- Duration and frequency of treatment / exposure:
- 1 to 4 hours after administration
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.5-1 mCi of ¹¹³m-In and 2-5 mg of DTPMP
- No. of animals per sex per dose / concentration:
- No data
- Positive control reference chemical:
- 10-20 µCi of ⁸⁵Sr was used as biological standard
Results and discussion
Main ADME resultsopen allclose all
- Type:
- distribution
- Results:
- 4.79 % body weight of DTPMP was distributed to average bones (Indium)
- Type:
- excretion
- Results:
- 70 % of DTPMP was excreted in the urine at 4 hours post-administration
Toxicokinetic / pharmacokinetic studies
- Details on distribution in tissues:
- The liver and soft tissue concentration of the indium complexes was lower than the ⁸⁵Sr concentration. The bone marrow concentration was low. The bone-to-blood, bone-to-marrow and bone-to-muscle ratios were comparable to those for ⁸⁵Sr.
- Details on excretion:
- At 4 hours post-administration, almost 70 % of DTPMP complex was excreted in the urine.
Toxicokinetic parameters
- Toxicokinetic parameters:
- half-life 1st: 100 min
Metabolite characterisation studies
- Metabolites identified:
- not measured
Any other information on results incl. tables
Table 2: Distribution of ¹⁵³Sm-labeled DTPMP
Tissue |
Distribution following 4h intravenous administration (% dose/1% body weight) Subramanian (1975) (species: rabbit) |
|
Radiolabel |
85-Sr |
113m-In |
Blood |
0.7 |
0.4 |
Plasma |
Not determined |
Not determined |
Average bone |
8.1 |
4.8 |
Marrow |
0.3 |
0.2 |
Muscle |
0.2 |
0.04 |
Kidney |
0.9 |
2.3 |
Liver |
0.3 |
0.2 |
Testes |
Not determined |
Not determined |
Applicant's summary and conclusion
- Conclusions:
- The study reports that the polyfunctional phosphonate DTPMP-H selectively concentrates in the skeleton of experimental animals and has fast blood clearance.
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