Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 923-927-0 | CAS number: -
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vitro / ex vivo
- Type of information:
- other: review article
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- secondary literature
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Coordination compounds in medicinal chemistry
- Author:
- Chad W. Schwietert, John P. McCue
- Year:
- 1 999
- Bibliographic source:
- Coordination Chemistry Reviews 184 67–89
Materials and methods
- Objective of study:
- other: review article
- Principles of method if other than guideline:
- A review of work involving the development of Fe(II), Pt(II), and Ti(IV) complexes as pharmaceuticals, and what this work reveals about transport of metal compounds across cell membranes
Results and discussion
Applicant's summary and conclusion
- Executive summary:
This review covers the early uses of titanium (IV) compounds to treat topical infections, investigations into anti-tumour activity, effects on proteases, and effects on bacteria. The article also provides a review of titanium (IV) transport into cells. Studies in both man and in animals given titanium (IV) compounds through the orak route, and via i.p and i.m. injection have shown titanium may be taken up into lungs, liver, kidney, heart and spleen.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
