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EC number: 257-104-6 | CAS number: 51277-96-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Freshwater
- Hazard assessment conclusion:
- PNEC aqua (freshwater)
- PNEC value:
- 45.5 ng/L
- Assessment factor:
- 1 000
- Extrapolation method:
- assessment factor
- PNEC freshwater (intermittent releases):
- 455 ng/L
Marine water
- Hazard assessment conclusion:
- PNEC aqua (marine water)
- PNEC value:
- 4.55 ng/L
- Assessment factor:
- 10 000
- Extrapolation method:
- assessment factor
- PNEC marine water (intermittent releases):
- 45.5 ng/L
STP
- Hazard assessment conclusion:
- PNEC STP
- PNEC value:
- 200 mg/L
- Assessment factor:
- 10
- Extrapolation method:
- assessment factor
Sediment (freshwater)
- Hazard assessment conclusion:
- PNEC sediment (freshwater)
- PNEC value:
- 158 µg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Sediment (marine water)
- Hazard assessment conclusion:
- PNEC sediment (marine water)
- PNEC value:
- 15.8 µg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Hazard for air
Air
- Hazard assessment conclusion:
- no hazard identified
Hazard for terrestrial organisms
Soil
- Hazard assessment conclusion:
- PNEC soil
- PNEC value:
- 934 µg/kg soil dw
- Extrapolation method:
- equilibrium partitioning method
Hazard for predators
Secondary poisoning
- Hazard assessment conclusion:
- no potential for bioaccumulation
Additional information
PNEC aqua (freshwater), PNEC aqua (marine), PNEC aqua (intermittent release)
Three acute studies with freshwater fish, invertebrates and algae are available for C16 Alkylamidopropyltrimethylammonium Chloride, but no long-term or reproduction study, nor studies with marine organisms. Therefore, in accordance with the Guidance on Information requirements and chemical safety assessment, R.10, an assessment factor of 1000 was applied and the PNEC aqua (freshwater) was derived from the 96 h LC50 value of 45.5 µg/L, determined with embryonic stages of Danio rerio, the most sensitive of the organisms tested. This results in a PNECaqua (freshwater) of 45.5 ng/L.
An assessment factor of 10000 was applied and the PNEC aqua (marine) was derived from the 96 h LC50 value of 45.5 µg/L, determined with embryonic stages of Danio rerio. This results in a PNECaqua (marine) of 4.55 ng/L.
An assessment factor of 100 was applied to the lowest L(E)C50, which was the 96 h LC50 = 45.5 µg/L, determined with embryonic stages of Danio rerio. Thus, the PNECaqua(Intermittent release) was calculated to be 455 ng/L.
PNEC STP
The PNEC STP was based on the 14 d NOEC of 2000 mg/L obtained in a Ready Biodegradability - Manometric Respirometry Test. Based on the available data, an assessment factor of 10 was applied in accordance with the Guidance in Information requirements and chemical safety assessment, R.10, to calculate the PNEC STP = 200 mg/L.
PNEC air
The registration substance has a low vapour pressure of 2.7E-07 Pa at 20°C. Based on this no risk for air breathing animals and humans is expected.
PNECoral (secondary poisoning)
Bioaccumulation potential has been estimated to be low. There is no concern for secondary poisoning and therefore no PNECoral (secondary poisoning) was derived.
PNEC sediment(freshwater), PNEC sediment (marine waters), PNEC soil
No toxicity tests with sediment dwelling or terrestrial organisms are available. Thus, in accordance with the Guidance on information requirements and chemical safety assessment, Chapter R.10: Characterisation of dose [concentration]-response for environment, 2008, the PNEC for freshwater and marine water sediment as well as the PNEC soil have been calculated with the equilibrium partitioning method using EUSES 2.1.
The following data have been taken into account for calculation:
Molecular weight |
291.07 g/mol |
Melting point |
89°C |
Vapour pressure |
2.7E-07 Pa at 20°C (Set to minimum value of 1E-06 in EUSES) |
Water solubility |
203 mg/L at 20.1!C |
Log Kow |
2.49 |
PNEC Aqua(freshwater) |
45.5 ng/L |
PNEC Aqua(marine water) |
4.55 ng/L |
Kd |
915.22 L/kg |
Kp (soil-water) |
1372.83 L/kg |
Kp (sediment-water) |
457.61 L/kg |
Kp (suspended matter-water) |
228.8 L/kg |
Kp (solids-water in raw sewage sludge) |
27.5 L/kg |
Kp (solids-water in settled sewage sludge) |
27.5 L/kg |
Kp (solids-water in activated sewage sludge) |
27.5 L/kg |
Kp (solids-water in effluent sewage sludge) |
27.5 L/kg |
The calculation resulted in a PNEC sediment(freshwater) of 158 µg/kg sediment dw, a PNEC sediment (marine waters) of 15.8 µg/kg sediment dw and a PNEC soil of 934 µg/kg soil dw.
Conclusion on classification
The most sensitive organism to C16 Alkylamidopropyltrimethylammonium Chloride was Danio rerio. Thus, the lowest acute toxicity value is the 96 h LC50 to embryonic stages of Danio rerio of 45.5 µg/L. This value was used for the calculation of PNECs. Chronic toxicity data are available for algae only (ErC10 = 0.205 mg/L).
In accordance with Regulation EC No 1272/2008, based on these results and the substance being rapidly biodegradable, C16 Alkylamidopropyltrimethylammonium Chloride has to be classified as Aquatic Acute 1 with an M factor of 10 and Aquatic Chronic 3.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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