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Diss Factsheets
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EC number: 291-768-8 | CAS number: 90480-35-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin irritation/corrosion
For skin irritation and skin corrosion there is one key in vitro study available each. Both studies were performed according to their respective OECD guidelines and in compliance to GLP.
Under the experimental conditions reported, the test item is irritant to skin but is non corrosive.
Eye irritation
For eye irritation there is one key in vivo test available. The in vivo study (1984) was performed according to OECD guideline 405 but not according to GLP (pre-GLP).
The test item is not irritant to the eye in the key in vivo study.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation/corrosion
One key in vitro study was performed to assess the irritation potential of the test item by means of the Human Skin Model Test. The test was according to OECD 439 and GLP.
Compared to the relative absorbance value of the negative control the mean relative absorbance value was reduced to 37.4% after exposure of the skin tissues to the test item, which is below the threshold for irritancy of ≤ 50%.
In conclusion, it can be stated that in this study and under the experimental conditions reported, the test item is irritant to skin.
One key in vitro study was performed to assess the corrosive potential of the test item by means of the Human Skin Model Test with EpiDerm™ tissues models. The study was performed in compliance to OECD TG 431 and GLP.
Independent duplicate tissues of EpiDerm™ were exposed to either the test item, the negative control (deionised water) or the positive control (8.0 N KOH) for 3 minutes and 1 hour, respectively.
After exposure of the tissues to the test item the corrected relative absorbance value did not decrease (101.1%) after 3 minutes exposure as well as after 1 hour exposure (119.7%,corrected value).
Since the thresholds for corrosivity are defined to be 50% after the 3minutes exposure and 15% after the 1 hour exposure, the test item is not considered to be corrosive.
Ski Eye irritation
The key study (1984) evaluated the eye irritant effects of the test item according to OECD 405.
100% of the test item was applied to the right eye of 3 rabbits, while the left served as control. Reactions were read 1, 24, 48 and 72 hours after treatment.
The test material caused irritation in all rabbits 1 hour after application. After 24 hours only 2 animals showed mild conjunctival inflammation, however, the reactions were fully reversible.
The calculated mean scores at 24, 48 and 72 hours for the 3 animals were 0.0 for the cornea, 0.0 for the iris, 0.2 for the conjuctival redness and 0.0 for conjunctival chemosis.
The substance is not irritant to the eye and should not be classified.
Justification for classification or non-classification
Skin irritation/corrosion
In conclusion, it can be stated that under the reported experimental conditions and according to EU CLP regulations, the test item is irritant to skin and should be classified as category 2 (irritant) and the test item is non corrosive to skin and does not need to be classified as corrosive.
Eye irritation
The criteria to classify a substance for eye irritation are set out in Table 3.3.1 and Table 3.3.2 of the EU Regulation No. 1272/2008 on the Classification, Labelling and Packaging of Substances and Mixtures (CLP).
Accordingly, test item is not irritant to the eye in the key in vivo study (1984) and does not need to be classified.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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