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EC number: 268-439-2 | CAS number: 68084-48-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2018-04-03 to 2018-05-08
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 1995
- Deviations:
- yes
- Remarks:
- Two vessels were set up in a parallel design, each vessel was sampled several times instead of sampling one vessel at every point in time/ exclusion of O2 and CO2, under inert gas (argon)
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- 2008
- Deviations:
- yes
- Remarks:
- Two vessels were set up in a parallel design, each vessel was sampled several times instead of sampling one vessel at every point in time/ exclusion of O2 and CO2, under inert gas (argon)
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- signed 2016-05-31
- Type of method:
- flask method
- Specific details on test material used for the study:
- State of matter and appearance: Green viscous liquid
Storage conditions: Room temperature tightly closed - Key result
- Water solubility:
- 183 mg/L
- Conc. based on:
- test mat. (dissolved fraction)
- Loading of aqueous phase:
- 1 g/L
- Incubation duration:
- 35 d
- Temp.:
- 20 °C
- pH:
- >= 5.86 - <= 5.92
- Remarks on result:
- other: S.D. ± 2 mg/L
- Remarks:
- calculated on mean measured dissolved copper concentration of 23.6 mg/L and a copper content of 12.89 %.
- Water solubility:
- 23.6 mg/L
- Conc. based on:
- element (dissolved fraction)
- Remarks:
- Cu
- Loading of aqueous phase:
- 1 other: g test item /L
- Incubation duration:
- 35 d
- Temp.:
- 20 °C
- pH:
- >= 5.86 - <= 5.92
- Remarks on result:
- other: S.D.: ± 0.2 mg/L
- Details on results:
- - Mean temperature: 20.0 ± 0.3 °C
- pH values: solutions containing the test item: 5.8 – 6.1, method blanks: 5.6 - 6.4
- Oxygen concentration: No oxygen was measurable
- Turbidity: The turbidity in samples from test was <1 NTU indicating that filtered solutions did not contain any undissolved material immediately after filtering, excluding test item loaded vessels after 35 days. Turbidity of test item loaded solutions after filtration of both vessels after 35 days was not measured by mistake. This is not critical because throughout the test the turbidity was always < 1 NTU.
Analytical measurements
The increase of concentrations from day 34 to day 35 was less than 15 %. Thus, the validity criteria as foreseen in OECD 105 and Regulation 440/2008/EC A.6 were fulfilled.
Copper concentrations increased during the test from day 1 and 35 and even slightly from day 34 to day 35. Thus, an equilibrium could not be observed. However, further sampling was not possible. Therefore, the water solubility of the test item is estimated with 183 ± 2 mg/L after 35 days based on the measured dissolved copper concentration of 23.6 ± 0.2 mg Cu/L on day 35 and a copper content of 12.89 % in the test item according to: 23.6 ± 0.2 mg/L (measured dissolved Cu concentration) x 100 % / 12.89 % (amount of Cu in test item) = 183 ± 2 mg/L. - Conclusions:
- Under the conditions of this test (under exclusion of CO2 and O2, under inert gas; flask method; loadings of 1.00002 and 1.00216 g/L test substance in two replicates, respectively), a solubility equilibrium was not reached after day 35 of testing. The mean measured dissolved copper concentration on day 35 at 20.0 ± 0.3 °C is 23.6 ± 0.2 mg/L.
This corresponds to a water solubility of dissolved copper(2+) neodecanoate of 183 ± 2 mg/L, calculated on a copper content of 12.89 %.
Reference
ICP-OES
ICP-OES measurement series with corresponding LOD/LOQ, correlation coefficient and sum of quality assurance samples and recovery
Calibration [μg/L] – lowest and highest calibration point |
Chosen wavelength [nm] |
LOD [μg Cu/L] |
LOQ [μg Cu/L] |
correlation coefficient |
Sum of quality assurance samples | Recovery of quality assurance samples [%] |
February 19, 2018; measurement of samples from non GLP preliminary test |
||||||
0 – 1000 (total of 13 calibration points, 13 used + blank) |
219.227 |
1.90 |
5.71 |
1.00000 |
20 |
100 |
April 26, 2018; measurement of test samples (21 d and 22 d) and method blanks |
||||||
1 – 500 (total of 13 calibration points, 13 used + blank) |
327.395 |
1.05 |
3.15 |
0.99997 |
10 |
100 |
Recovery/ validation data Copper of measurement series
Element Cu | Recovery [%] | SD [%] | n (total) | n (valid) |
February 19, 2018 (non-GLP preliminary test) | ||||
TMDA-70.2 lot no. 0916 (dilution factor 10), nominal value Cu: 407 μg/L – diluted 40.7 μg/L | 101 | 1.3 | 3 | 3 |
TMDA-70.2 lot no. 0916, nominal value Cu: 407 μg/L | 102 | 3 | 4 | 4 |
Quality control standard (Roth) 75 μg/L | 105 | 1 | 4 | 4 |
Quality control standard (Roth) 750 μg/L | 103 | <1 | 4 | 4 |
Recalibration standard 250 μg/L | 99.5 | 1.0 | 4 | 4 |
April 26, 2018 | ||||
TMDA-70.2 lot no. 0917 (dilution factor 2), nominal value Cu: 406 μg/L – diluted 203 μg/L | 101 | 1.3 | 3 | 3 |
Quality control standard (Roth) 300 μg/L | 106 | 1.2 | 3 | 3 |
Recalibration standard 100 μg/L | 101 | 0.6 | 3 | 3 |
Fortification of measurement series on April 26, 2018.
Sample | element | measured concentration [μg/L] | calculated level after addition [μg/L] | recovery [μg/L] / [%] |
Vessel 1 sample a after 22d – (dilution 100-fold); 1 mL of sample + 3 mL 400 μg/L standard | Cu | 212 | 282 | 276 / 97.6 |
ICP-MS
ICP-MS measurement series with corresponding LOD/LOQ, correlation coefficient and sum of quality assurance samples and recovery
Calibration [μg/L] – lowest and highest calibration point |
Chosen isotope and mode |
LOD [μg Cu/L] |
LOQ [μg Cu/L] |
correlation coefficient |
Sum of quality assurance samples |
Recovery of quality assurance samples [%] |
April 10, 2018; measurement of test samples (1 d, 2 d and 3 d) and method blanks |
||||||
1– 500 (total of 13 calibration points, 13 used + blank) | 65Cu in high helium mode | 0.004 | 0.012 | 1.000 | 13 | 100 |
April 19, 2018; measurement of test samples (13 d and 14 d) and method blanks |
||||||
1 – 500 (total of 13 calibration points, 13 used + blank) |
63Cu in no gas mode |
0.016 |
0.047 |
0.9999 |
10 |
100 |
May 07, 2018; measurement of method blanks (34 d) |
||||||
1 – 500 (total of 13 calibration points, 13 used + blank) |
65Cu in high helium mode |
0.021 |
0.061 |
0.9997 |
8 |
100 |
May 08, 2018; measurement of test samples (34 d and 35 d) and method blanks | ||||||
1 – 500 (total of 13 calibration points, 13 used + blank) | 63Cu in helium mode | 0.001 | 0.002 | 0.9999 | 13 | 100 |
Recovery/ validation data Copper of measurement series
Element Cu | Recovery [%] | SD [%] | n (total) | n (valid) |
April 10, 2018 | ||||
TMDA-70.2 lot no. 0917 (dilution factor 4), nominal value Cu: 406 μg/L – diluted 203 μg/L | 104 | 5.1 |
4 |
4 |
Quality control standard (Roth) 250 μg/L |
112 |
2.9 |
4 |
4 |
Recalibration standard 100 μg/L |
101 |
1.6 |
4 |
4 |
April 19, 2018 |
||||
TMDA-70.2 lot no. 0917 (dilution factor 4), nominal value Cu: 406 μg/L – diluted 101.5 μg/L |
98.3 |
2.5 |
3 |
3 |
Quality control standard (Roth) 250 μg/L |
106 |
4.4 |
3 |
3 |
Recalibration standard 100 μg/L |
95.3 |
0.9 |
3 |
3 |
May 07, 2018 |
||||
TMDA-70.2 lot no. 0917 (dilution factor 2), nominal value Cu: 406 μg/L – diluted 203 μg/L |
96.7 |
0.4 |
2 |
2 |
Quality control standard (Roth) 400 μg/L |
102 |
0.4 |
3 |
3 |
Recalibration standard 100 μg/L |
102 |
1.6 |
3 |
3 |
May 08, 2018 |
||||
TMDA-70.2 lot no. 0917 (dilution factor 2), nominal value Cu: 406 μg/L – diluted 203 μg/L |
97.1 |
2.4 |
4 |
4 |
Quality control standard (Roth) 400 μg/L |
99.4 |
2.6 |
4 |
4 |
Recalibration standard 100 μg/L |
99.6 |
1.8 |
4 |
4 |
Fortification of measurement series
sample | element | measured concentration [μg/L] | calculated level after addition [μg/L] | recovery [μg/L] / [%] |
April 10, 2018 | ||||
Vessel 1 sample a after 3d – (dilution 100-fold); 1 mL of sample + 4 mL 300 μg/L standard | Cu | 154 | 271 | 271 / 100 |
April 19, 2018 | ||||
Vessel 1 sample a 13d – (dilution 100-fold); 1 mL sample 4 mL 400 μg/L standard | Cu | 165 | 353 | 343 / 97.2 |
May 08, 2018 | ||||
Vessel 1 sample a 35d – 1 mL sample 4 mL 400 μg/L standard | Cu | 236 | 367 | 360 / 98.0 |
Mean dissolved copper concentrations of solutions containing the test item
Sampling [d] | sample | LOD [μg/L] |
LOQ [μg/L] |
Cu conc. per vessel ± SD [g/L] |
Mean Cu conc. all vessels ± SD [g/L] |
Variation / change between samplings [%] |
1 | Vessel 1 | 0.004 | 0.012 | 10.9 ± 0.3 | 10.2 ± 1.0 | - |
Vessel 2 | 0.004 | 0.012 | 9.51 ± 0.20 | |||
2 | Vessel 1 | 0.004 | 0.012 | 14.7 ± 0.1 | 14.2 ± 0.7 | 39.2 |
Vessel 2 | 0.004 | 0.012 | 13.7 ± 0.1 | |||
3 | Vessel 1 | 0.004 | 0.012 | 15.9 ± 0.8 | 15.2 ± 1.1 | 6.7 |
Vessel 2 | 0.004 | 0.012 | 14.4 ± 0.5 | |||
13 | Vessel 1 | 0.016 | 0.047 | 15.7 ± 1.2 | 16.8 ± 1.6 | 10.6 |
Vessel 2 | 0.016 | 0.047 | 17.9 ± 0.5 | |||
14 | Vessel 1 | 0.016 | 0.047 | 16.6 ± 0.1 | 17.7 ± 1.5 | 5.5 |
Vessel 2 | 0.016 | 0.047 | 18.7 ± 1.1 | |||
21 | Vessel 1 | 1.05 | 3.15 | 19.9 ± 0.1 | 20.6 ± 1.0 | 16.4 |
Vessel 2 | 1.05 | 3.15 | 21.3 ± 0.1 | |||
22 | Vessel 1 | 1.05 | 3.15 | 20.9 ± 0.4 | 20.8 ± 0.2 | 1.3 |
Vessel 2 | 1.05 | 3.15 | 20.7 ± 0.7 | |||
34 | Vessel 1 | 0.001 | 0.002 |
22.8 ± 0.3 |
23.3 ± 0.6 |
11.6 |
Vessel 2 |
0.001 |
0.002 |
23.7 ± 0.1 |
|||
35 |
Vessel 1 |
0.001 |
0.002 |
23.5 ± <0.1 |
23.6 ± 0.2 |
1.7 |
Vessel 2 |
0.001 |
0.002 |
23.7 ± 0.4 |
Description of key information
The mean measured dissolved copper concentration on day 35 at 20.0 ± 0.3 °C is 23.6 ± 0.2 mg/L.This corresponds to a water solubility of dissolved copper(2+) neodecanoate of 183 ± 2 mg/L, calculated on a copper content of 12.89 %.
Key value for chemical safety assessment
- Water solubility:
- 183 mg/L
- at the temperature of:
- 20 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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