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Diss Factsheets
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EC number: 256-589-1 | CAS number: 50448-95-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Version / remarks:
- 1992
- GLP compliance:
- not specified
- Analytical monitoring:
- no
- Vehicle:
- no
- Details on test solutions:
- Pretreatment of the test substance: dilution in tap water used for ther fish-test whilst shaking on a shaking machine for 24h followed by separation of the water-insoluble part from the water soluble part of the test substance via filtration through paper filters previously rinsed with deionised water.
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- TEST ORGANISM
- Common name: zebrafish
- Source: Aquafarm Ryba, Zeven - Test type:
- semi-static
- Water media type:
- freshwater
- Total exposure duration:
- 96 h
- Nominal and measured concentrations:
- Screening test: 10, 1, 0.1 mg/L
1st main test: 10, 8, 4, 2, 1 mg/L
2nd main test: 1, 0.8, 0.4, 0.2, 0.1 mg/L - Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 1.03 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Sublethal observations / clinical signs:
Screening test
Concentration of Test Substance
Number of dead fish [%]
24 h
48 h
72 h
96 h
10
100
100
100
100
1
0
0
0
0
0.1
0
0
0
0
1° Main test (Static Test Procedure):
Concentration of Test Substance
Number of dead fish [%]
24 h
48 h
72 h
96 h
Control
0
0
0
0
10
100
100
100
100
8
100
100
100
100
4
100
100
100
100
2
100
100
100
100
1
86
86
86
86
2" Main test (Definitive Test, Semi-Static Test Procedure):
Concentration of Test Substance
Number of dead fish [%]
24 h
48 h
72 h
96 h
Control
0
0
0
0
1.0
29
29
29
43
0.8
14
14
14
14
0.4
0
0
0
0
0.2
0
0
0
0
0.1
0
0
0
0
- Executive summary:
The test substance was tested under semi-static conditions for toxicity towards fish according to OECD-Test Guideline 203. For this purpose the animals were exposed to different concentrations of the test substance. Under the conditions used for this study the LCso-value after 96h was caiculated to be 1.03 mg of test substance per litre.
Reference
Description of key information
LC50 = 1.03 mg/L (nominal)
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Dose descriptor:
- LC50
- Effect concentration:
- 1.03 mg/L
Additional information
EHMP was tested under semi-static conditions for toxicity towards fish according to OECD-Test Guideline 203. For this purpose the animals were exposed to different concentrations of the test substance. Under the conditions used for this study the LC50-value after 96 h was caiculated to be 1.03 mg of test substance per litre.
Nominal values represent the real environmental conditions because the test substance is rapidly oxidized by the oxygen content in the aqueous phase. As the transformation products are less toxic than the parent substances (no free –SH groups) regulatory endpoints calculated on the basis of nominal concentrations represent a realistic worst case approach.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.