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Diss Factsheets
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EC number: 208-594-5 | CAS number: 534-22-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic and germ cell study: gene mutation
- Remarks:
- genotoxic effects in somatic and meiotic tissue
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 989
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- not specified
- Type of assay:
- other: genotoxic effects in somatic and meiotic tissue
Test material
- Reference substance name:
- 2-methylfuran
- EC Number:
- 208-594-5
- EC Name:
- 2-methylfuran
- Cas Number:
- 534-22-5
- Molecular formula:
- C5H6O
- IUPAC Name:
- 2-methylfuran
Constituent 1
- Specific details on test material used for the study:
- not specified
Test animals
- Species:
- mouse
- Strain:
- Swiss
- Remarks:
- albino
- Details on species / strain selection:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- test animals:
age: 8 to 10 weeks
Administration / exposure
- Route of administration:
- oral: feed
- Vehicle:
- not specified
- Details on exposure:
- somatic test system: feeding: 24 h interval for five days
meiotic test system: 24 h feeding - Duration of treatment / exposure:
- somatic test system: 5 days
meiotic test system: 1 day - Frequency of treatment:
- 24 h
- Post exposure period:
- somatic test system: scoring after 24, 48 and 72 hours after oral feeding
meiotic test system: 1 to 5 weeks after exposure
Doses / concentrationsopen allclose all
- Dose / conc.:
- 1 000 ppm
- Dose / conc.:
- 2 000 ppm
- Dose / conc.:
- 4 000 ppm
- No. of animals per sex per dose:
- not specified
- Control animals:
- not specified
- Positive control(s):
- not specified
Examinations
- Tissues and cell types examined:
- somatic test sytem: bone marrow cells (synthesis of spindle proteins, cell division)
meiotic test system: sperm cells (spermatogenetic cycle, sperm abnormalities) - Details of tissue and slide preparation:
- not specified
- Evaluation criteria:
- not specified
- Statistics:
- not specified
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- Under the conditions of the test, the test substance did not induce chromosome mutations in bone marrow cells, inhibit synthesis of spindle proteins or retardation of cell division. In a meiotic test system, the test substance did not induce genotoxic effects or causing sperm head abnormalities. In conclusion the test substance did not cause any genotoxic hazards to the mammalian test system.
- Executive summary:
In this study 2-methylfuran was evaluated by a cytogenetic assay employing somatic and meiotic tissues on 8 to 10 week old Swiss albino mice as test system.
In the somatic test system chromosome mutations were scored from bone marrow cells, 24, 48 and 72 h after oral feeding at 1000, 2000 and 4000 ppm at 24 h intervals for five days. The test substance did not induce chromosome mutations in bone marrow cells, inhibit synthesis of spindle proteins or retardation of cell division.
In a meiotic test system, the test was carried out for 24 h and scored from 1 to 5 weeks at weekly intervals to cover one spermatogenetic cycle. The test substance did not induce genotoxic effects or causing sperm head abnormalities.
In conclusion, under the conditions of the test the test substance did not cause any genotoxic hazards to the mammalian test system.
The assay was not performed according to an OECD TG nor in compliance to GLP.
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