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EC number: 241-503-7 | CAS number: 17496-08-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
Test material
- Reference substance name:
- Ammonium propionate
- EC Number:
- 241-503-7
- EC Name:
- Ammonium propionate
- Cas Number:
- 17496-08-1
- Molecular formula:
- C3H6O2.H3N
- IUPAC Name:
- ammonium propionate
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Doses:
- STARTING DOSE: 2000 mg/kg bw
- No. of animals per sex per dose:
- 3
- Control animals:
- no
- Details on study design:
- MORTALITY AND CLINICAL SIGNS
On the day of dosing, all animals were observed for signs of toxicity and death, periodically during the first 24 hours with special attention given during the first 4 hours (i.e. at 10 minutes, 30 minutes, 1 hour, 2 and 4 hours following dosing) and thereafter they were observed once a day for 14 days.
The appearance, progress and disappearance of these signs were recorded
BODY WEIGHTS
The body weights of rats were individually recorded at one day prior to dosing (day 0), on the day of dosing (day 1, for fasting body weight), on day 7 and at termination on day 15. Weight changes and group mean values were computed over day 0 body weights.
NECROPSY AND HISTOPATHOLOGY
At end of the study all animals were weighed and humanely sacrificed by carbon dioxide asphyxiation. All animals in the study including those found dead during study, were subjected to a complete necropsy and the gross pathological changes were recorded. Histopathological evaluations were not conducted in absence of any remarkable gross pathology.
Results and discussion
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- ca. 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- When tested on three female rats at the dose level of 2000 mg/kg body weight, Ammonium propionate (CAS: 17496-08-1; EC: 241-503-7) in aqueous solution (50-55%) did not induce any abnormal clinical signs in the treated rats during the 14 days observation period following application
- Gross pathology:
- No gross pathological alterations were encountered in any of the female rats when sacrificed at termination of the study.
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- In this study, single oral administration of undiluted Ammonium propionate (CAS: 17496-08-1; EC: 241-503-7) in aqueous solution (50-55%) was made to groups of three female rats in step-wise manner to assess its acute toxicity.
Following the starting dose of 2000 mg/kg body weight, which was also repeated in the second step of the test, Ammonium propionate (CAS: 17496-08-1; EC: 241-503-7) in aqueous solution (50-55%) did not induce any abnormal clinical signs in the treated rats during the 14 days observation period following application. Body weight change by treated rats was not adversely affected during the 14 day observation period post dosing. As evident at terminal necropsy Ammonium propionate (CAS: 17496-08-1; EC: 241-503-7) in aqueous solution (50-55%) did not induce any gross pathological alterations in their organs / tissues.
Based on these results, and according to the criteria for classification (described under section 3.5 of this report) viz. Globally Harmonised System (GHS) for classification of chemicals which cause acute toxicity, OECD series on testing and assessment, Number 33, and the European Commission’s Dangerous Substances Directive (Directive 2001/59/EC) and also the Classification, Labelling and Packaging of Substances Regulation (Regulation 1272/2008/EC), the test item, Ammonium propionate (CAS: 17496-08-1; EC: 241-503-7) in aqueous solution (50-55%), is classified in GHS Category 5 or unclassified for the obligatory labelling requirement for oral toxicity. This category corresponds to an LD50 cut of value being 5000 mg/kg body weight.
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