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EC number: 241-698-9 | CAS number: 17696-62-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Hazard for air
Hazard for terrestrial organisms
Hazard for predators
Additional information
Conclusion on classification
According to regulation (EC) No 1907/2006 toxicity tests with fish are not required for a tonnage of 1 to 10 tpa. Nevertheless, according to Article 12 of the mentioned regulation shall include all physicochemical, toxicological and ecotoxicological information that is relevant and available to the registrant. Three trophic levels (fish, daphnia, algae) are covered by the toxicity data set and can be used for hazard assessment. Fish species were observed to be the most sensitive species:
The available results from the fish studies reveal that fish is the most sensitive organism towards phenyl 4-benzoate and are therefore included in the present dossier and considered for classification according to Regulation (EC) No 1272/2008.
Two publications on short-term toxicity for fish are available indicating the following effect values:
The key study from Yamamoto et al. revealed a 96 h LC50 for Oryzias latipes. In the exposure experiment from Dobbins et al. (2009) a 48 h LC 50 of 3.3 mg/L was determined for Pimephales promelas, which is in the same range as the LC50 derived by Yamamoto et al. a 96 h LC50 for Oryzias latipas equalling 0.73 mg/L.
The lower value was set as key value for acute toxicity.
The key value for long-term toxicity to fish results from a VTG assay (14 -d exposure of male medaka). The effect concentrations from Yamamoto et al. (2011) were determined as follows:
LOEC: 20 µg/L a.i./L
NOEC: 100 µg a.i./L
A second long-term study (7 -day exposure of Pimephales promelas larvae, Dobbins et al. 2009) indicates similar values:
LOEC: 1.7 mg/L
NOEC: 0.85 mg/L
Based on the mentioned effect concentrations phenyl 4-hydroxybenzoate has to be classified as Aquatic Acute 1 (H400) and Aquatic Chronic 1 (H410).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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