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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Toxicity to microorganisms

Currently viewing:

Administrative data

Endpoint:
toxicity to microorganisms, other
Remarks:
antibacterial effect
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
secondary literature

Data source

Reference
Reference Type:
review article or handbook
Title:
Unnamed
Year:
2006

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
The antibacterial effect of pressed and unpressed high purity SAS (Aerosil, unspecified) (0.2 g silica + 0.15 ml bacteria strain suspension) kept at 22°C was investigated
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Silicon dioxide
EC Number:
231-545-4
EC Name:
Silicon dioxide
Cas Number:
7631-86-9
Molecular formula:
O2Si
IUPAC Name:
Silicon dioxide
Test material form:
solid
Specific details on test material used for the study:
high purity SAS (Aerosil, unspecified)

Test organisms

Test organisms (species):
other: Escherichia coli, Proteus sp., Pseudomonas aeruginosa, Aerobacter aerogenes, Micrococcus pyrogenes aureus, Streptococcus faecalis, Streptococcus pyrogenes humanus, Corynebacterium diphtheriae, Candida albicans and Bacillus subtilis.

Study design

Total exposure duration:
3 d

Results and discussion

Effect concentrations
Key result
Duration:
3 d
Dose descriptor:
other: mortality
Effect conc.:
ca. 0.2 other: g
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
other: mortality
Remarks on result:
not determinable
Details on results:
The antibacterial effect of pressed and unpressed high purity SAS (Aerosil, unspecified) (0.2 g silica + 0.15 ml bacteria strain suspension) kept at 22°C has been investigated (SAS is sometimes pressed to remove air before transportation). Rod-shaped gram-negative organisms (Escherichia coli, Bacterium proteus, Pseudomonas aeruginosa and Aerobacter aerogenes) died between 6 hours and 3 days in contact with unpressed SAS. Gram-positive micro-organisms were somewhat more resistant. In addition, the tests demonstrated that survival of bacteria was shorter in unpressed than in pressed SAS

Applicant's summary and conclusion

Conclusions:
The antibacterial effect of pressed and unpressed high purity SAS (Aerosil, unspecified) (0.2 g silica + 0.15 ml bacteria strain suspension) kept at 22°C has been investigated (SAS is sometimes pressed to remove air before transportation). Rod-shaped gram-negative organisms (Escherichia coli, Bacterium proteus, Pseudomonas aeruginosa and Aerobacter aerogenes) died between 6 hours and 3 days in contact with unpressed SAS. Gram-positive micro-organisms were somewhat more resistant. In addition, the tests demonstrated that survival of bacteria was shorter in unpressed than in pressed SAS.
Executive summary:

The antibacterial effect of pressed and unpressed high purity SAS (Aerosil, unspecified) (0.2 g silica + 0.15 ml bacteria strain suspension) kept at 22°C has been investigated (SAS is sometimes pressed to remove air before transportation). Rod-shaped gram-negative organisms (Escherichia coli, Bacterium proteus, Pseudomonas aeruginosa and Aerobacter aerogenes) died between 6 hours and 3 days in contact with unpressed SAS. Gram-positive micro-organisms were somewhat more resistant. In addition, the tests demonstrated that survival of bacteria was shorter in unpressed than in pressed SAS