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EC number: 686-241-8 | CAS number: 81058-27-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 19 December 2016 - 07 July 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7840 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- column elution method
- Specific details on test material used for the study:
- - Batch n°: M16FB2273
- Analytical purity: 101.7%
- Expiration date: 12 September 2017
- Storage condition: at room temperature - Key result
- Water solubility:
- < 0.02 mg/L
- Conc. based on:
- test mat. (dissolved fraction)
- Remarks:
- No test item was detected at flow rate of 12 and 24 mL/h. The analysed concentrations are therefore reported to be below the limit of detection of the analytical method (0.02 mg/L)
- Loading of aqueous phase:
- 52 other: mg
- Incubation duration:
- 2 h
- Temp.:
- 20 °C
- pH:
- >= 8 - <= 8.3
- Details on results:
- Main test
No test item was detected at flow rate of 12 and 24 mL/h. The analysed concentrations are therefore reported to be below the LOD of the analytical method (i.e. < 0.020 mg/L).
To demonstrate proper preparation of the carrier material, an aliquot of the carrier material was analyzed. The test item was detected in this solution and therefore demonstrated that the test item was used for the preparation of the carrier material.
The turbidity of the eluates was < 0.2 NTU. According to this, no undissolved particles were detected in the eluates.
The analytical method was re-validated for different preparation of accuracy samples. The mean accuracy at each concentration level fell below the criterion 70.00-110.00 (results are archived in the raw data). The results were accepted and no correction was made since the water solubility is reported < limit of detection - Conclusions:
- The column elution method was applied for the determination of the water solubility of JNJ-42808389-AAA (T003421).
The water solubility of the test item at 20°C was <0.020 mg/L.
The pH of the aqueous samples was 8.0 and 8.3. - Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 19 May 2009 - 28 May 2009
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study not performed in accordance with the respective test guidelines. No GLP compliance.
- Qualifier:
- no guideline followed
- GLP compliance:
- no
- Type of method:
- other: visually
- Water solubility:
- < 0.01 other: g/100 mL
- Temp.:
- 20 °C
- pH:
- 8.3
- Conclusions:
- The water solubility of T003421 was determined visually. The results show a water solubility of < 0.01 g/100 mL at 20 °C and pH 8.3.
The results of the test can be considered reliable with restriction.
Referenceopen allclose all
Description of key information
The water solubility of T003421 was determined in a GLP study performed according to the OECD Guideline 105, EU Method A.6 and EPA OPPTS 830.7840 (K1, Ciric, 2017) and was reported to be <0.020 mg/L at 20°C and at pH 8.0 - 8.3.
Key value for chemical safety assessment
Additional information
In a supporting study performed at Anabiotec (K2, Vercruysse, 2009) the water solubility of T003421 was determined visually as <0.01 g/100 mL at 20°C and pH 8.3.
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