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Diss Factsheets
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EC number: 908-114-0 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- The in vivo test was performed before the REACH regulation came into force, requesting in vitro studies. This information is used for read-across to Citronellyl Acetate Multi
Cross-reference
- Reason / purpose for cross-reference:
- read-across: supporting information
Reference
- Endpoint:
- eye irritation: in vivo
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 2018
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Read-across information
- Justification for type of information:
- The read-across justification is presented in the Endpoint summary Irritation. The accompanying files are also attached there.
- Reason / purpose for cross-reference:
- read-across source
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Remarks:
- all animals tested
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Remarks on result:
- other: read-across from Citronellyl Acetate ('mono')
- Irritation parameter:
- iris score
- Basis:
- mean
- Remarks:
- all animals tested
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Reversibility:
- other: not applicable
- Remarks on result:
- other: read-across from Citronellyl Acetate ('mono')
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Remarks:
- all animals tested
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 3
- Reversibility:
- other: not applicable
- Remarks on result:
- other: read-across from Citronellyl Acetate ('mono')
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Remarks:
- all animals tested
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Remarks on result:
- other: read-across from Citronellyl Acetate ('mono')
- Interpretation of results:
- other: Not an eye irritant
- Remarks:
- according to EU CLP (EC No. 1272/2008 and its amendments.
- Conclusions:
- The substance is not considered an eye irritant based on adequate information of one its key constituents.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Citronellyl acetate
- EC Number:
- 205-775-0
- EC Name:
- Citronellyl acetate
- Cas Number:
- 150-84-5
- Molecular formula:
- C12H22O2
- IUPAC Name:
- 3,7-dimethyloct-6-en-1-yl acetate
- Test material form:
- liquid
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Dr. K. Thomae GmbH, Biberach, Germany
- Age at study initiation: young adults
- Animal identification: ear tattoo
- Weight at study initiation: females 3.60 kg, 3.96 kg; male 3.98 kg
- Housing: single housing, stainless stell wire mesh cages with grating, floor area: 3000 cm2
- Bedding: no bedding in the cages; sawdust in the waste trays
- Diet: Kliba-Labordiaet 341, Klingentalmuehle AG, Kaiseraugst, Switzerland (about 130 g/animal/day)
- Water: tap water (about 250 ml/animal/day)
- Acclimation period: at least 1 week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 - 24
- Humidity (%): 30 - 70
- Photoperiod (hrs dark / hrs light): 12 h / 12 h
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated eye of same animal
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 ml in single application to conjunctival sac of right eyelid - Duration of treatment / exposure:
- once continously
- Observation period (in vivo):
- 1 h, 24 h, 48 h, 72 h
- Number of animals or in vitro replicates:
- 3
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): no washing
GENERAL OBSERVATIONS
- check for dead or moribund animals: twice daily (Mo - Fr), once daily (Sa/Su)
SCORING SYSTEM:
-according to OECD guideline 405 (adopted Feb. 24, 1987) and EEC L 383A, B.5 (Dec. 29, 1992)
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Remarks:
- all animals tested
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Irritation parameter:
- iris score
- Basis:
- mean
- Remarks:
- all animals tested
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Reversibility:
- other: not applicable
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Remarks:
- all animals tested
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 3
- Reversibility:
- other: not applicable
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Remarks:
- all animals tested
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
Any other information on results incl. tables
For calculation of the means of opacity, iris, redness and swelling, the 24, 48 and 72 hours readings were taken into consideration.
Irritant response data:
Readings | Animal | cornea | Iris | conjunctiva | Symptoms | |||
opacity | area | redness | swelling | discharge | ||||
1 h | 1 | 0 | 0 | 0 | 1 | 0 | 2 | - |
2 | 0 | 0 | 0 | 1 | 0 | 1 | - | |
3 | 0 | 0 | 0 | 1 | 0 | 1 | - | |
24 h | 1 | 0 | 0 | 0 | 0 | 0 | 0 | - |
2 | 0 | 0 | 0 | 0 | 0 | 0 | - | |
3 | 0 | 0 | 0 | 0 | 0 | 0 | - | |
48 h | 1 | 0 | 0 | 0 | 0 | 0 | 0 | - |
2 | 0 | 0 | 0 | 0 | 0 | 0 | - | |
3 | 0 | 0 | 0 | 0 | 0 | 0 | - | |
72 h | 1 | 0 | 0 | 0 | 0 | 0 | 0 | - |
2 | 0 | 0 | 0 | 0 | 0 | 0 | - | |
3 | 0 | 0 | 0 | 0 | 0 | 0 | - | |
Mean 24 - 72 h | 1 | 0 | 0 | 0 | 0 | 0 | 0 | |
2 | 0 | 0 | 0 | 0 | 0 | 0 | ||
3 | 0 | 0 | 0 | 0 | 0 | 0 | ||
Mean | 0 | 0 | 0 | 0 | 0 | 0 |
Animal 1: female; animal 2: female; animal 3: male
Applicant's summary and conclusion
- Interpretation of results:
- other: Not an eye irritant.
- Remarks:
- according to EU CLP (EC No. 1272/2008, and its amendments).
- Conclusions:
- The scores for cornea opacity, conjunctiva effects (redness, swelling or discharge) and iris effects were 0 at all time-points for all rabbits. Based on these results, it is concluded that Citronellyl acetate (mono) has no eye irritant effects.
- Executive summary:
An in vivo eye study was performed with Citronellyl Acetate (‘mono’) according to OECD guideline 405 and following GLP principles. Three rabbits received a single instillation of 0.1 mL in the conjunctival sac of their right eyelid. No washing as performed, animals were observed at one hour after instillation and after 24, 48 and 72 hours. The scores for cornea opacity, conjunctiva effects (redness, swelling or discharge) and iris effects were 0 at all time-points for all rabbits. Based on these results, it is concluded that Citronellyl acetate (mono) has no eye irritant effects.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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