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Diss Factsheets
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EC number: 234-744-4 | CAS number: 12030-85-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- repeated dose toxicity: oral, other
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1965, July - August
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- The toxicity of Niobium salts
- Author:
- Downs W.L. et al.
- Year:
- 1 965
- Bibliographic source:
- American Industrial Hygiene Association Journal, 26:4, 337 - 346
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- - Principle of test: To investigate the sub-acute oral toxicity of Potassium Niobate
- Short description of test conditions: - Three groups (same number and sex) were fed diets containing 0, 0.10 and 1 % Potassium Niobate.
- Parameters analysed / observed: Body weight, histopathology of the liver, spleen, and kidney - GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Potassium niobate
- EC Number:
- 234-744-4
- EC Name:
- Potassium niobate
- Cas Number:
- 12030-85-2
- Molecular formula:
- K.NbO3
- IUPAC Name:
- niobium(5+) potassium trioxidandiide
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source of test material: Union Carbide Metals Co., Niagara Falls, N.Y.
Test animals
- Species:
- rat
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: feed
- Vehicle:
- not specified
- Details on oral exposure:
- DOSING SOLUTIONS: 0, 0.10 and 1.0% Potassium Niobate
- Duration of treatment / exposure:
- 7 weeks
Doses / concentrationsopen allclose all
- Dose / conc.:
- 1 mg/kg diet
- Dose / conc.:
- 10 mg/kg diet
- No. of animals per sex per dose:
- three groups of 5 males weanling rats each
- Control animals:
- yes, concurrent no treatment
Examinations
- Observations and examinations performed and frequency:
- BODY WEIGHT: Yes
- Time schedule for examinations: Weekly - Sacrifice and pathology:
- GROSS PATHOLOGY: Yes
Results and discussion
Results of examinations
- Clinical signs:
- not examined
- Mortality:
- mortality observed, treatment-related
- Description (incidence):
- - A total of 4 deaths occurred and two of these occurred in the control group
- Body weight and weight changes:
- no effects observed
- Food consumption and compound intake (if feeding study):
- not examined
- Food efficiency:
- not examined
- Water consumption and compound intake (if drinking water study):
- not examined
- Ophthalmological findings:
- not examined
- Haematological findings:
- not examined
- Clinical biochemistry findings:
- not examined
- Urinalysis findings:
- not examined
- Behaviour (functional findings):
- not examined
- Immunological findings:
- not examined
- Organ weight findings including organ / body weight ratios:
- no effects observed
- Gross pathological findings:
- no effects observed
- Neuropathological findings:
- not examined
- Histopathological findings: non-neoplastic:
- no effects observed
- Description (incidence and severity):
- Histopathological examination of sections of the liver, kidney, or spleen revealed no tissue changes that could be attributed to the ingestion of potassium niobate
- Histopathological findings: neoplastic:
- not examined
- Other effects:
- not examined
Effect levels
- Key result
- Dose descriptor:
- NOAEL
- Effect level:
- 10 mg/kg diet
- Based on:
- test mat.
- Sex:
- male
Applicant's summary and conclusion
- Conclusions:
- Potassium niobate was fed to three groups of 5 weaned, male rats each at dietary levels of 0, 0.10 and 1 % for a duration of 7 weeks. No treatment related effects were observed.
- Executive summary:
Potassium niobate was fed to three groups of 5 weaned, male rats each at dietary levels of 0, 0.10 and 1 % for a duration of 7 weeks. Histopathological examination of sections of the liver, kidney, or spleen revealed no tissue changes that could be attributed to the ingestion of potassium niobate.
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