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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 06 - 14 November 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2018
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 1995
- Deviations:
- yes
- Remarks:
- see principles of method if other than guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- Regulation (EC) No 440/2008
- Deviations:
- yes
- Remarks:
- see principles of method if other than guideline
- Principles of method if other than guideline:
- Due to the high water solubility of the test item, the present study was conducted according to a modified TG OECD 105 design. Instead of equilibrating substantial amounts of test item (about five times in excess) with water by stirring over several days and subsequently separating the test item from the saturated solution, water was added in a stepwise procedure to a defined amount of test item until complete dissolution occurred.
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- determination of total phosphorus was performed by a third laboratory under the QA system ISO/IEC 17025 and is therefore excluded from the statement of GLP compliance
- Type of method:
- flask method
Test material
- Reference substance name:
- Fructose-1,6-Diphosphate, raw: Glucose anaerobically fermented by Saccharomyces cerevisiae, concentrated, phosphorylated
- Molecular formula:
- Molecular formula of the eponymous compound: C6H14O12P2
- IUPAC Name:
- Fructose-1,6-Diphosphate, raw: Glucose anaerobically fermented by Saccharomyces cerevisiae, concentrated, phosphorylated
- Test material form:
- solid
- Details on test material:
- Batch No.: 18224600
Constituent 1
Results and discussion
Water solubility
- Key result
- Water solubility:
- >= 882 g/L
- Conc. based on:
- test mat. (dissolved fraction)
- Temp.:
- 22 °C
- pH:
- 4
- Details on results:
- Preliminary test
The preliminary test indicated a water solubility of >1000 g/L, as ca. 0.1 g were completely dissolved in 0.1 mL of ultra-pure water.
Main test
The results are given in the table in "any other information on results". The water solubility was determined as the mean of the triplicate test assays analysed. As this method does not ensure complete saturation of the solution, it is given as minimum value in mass per volume of solution. The test is satisfactory, if the concentrations of the three vessels do not differ by more than 15%.
Any other information on results incl. tables
Analytical determinations:
Test vessel | pH | Determined total phosphorous concentrations (g/L) | Determined test concentrations (g/L)* |
No. 1 |
4 |
104 |
884 |
No. 2 |
4 |
103 |
875 |
No. 3 |
4 |
105 |
888 |
|
|
Overall Mean |
882 |
*Using a total phosphorous content of 11.77%
The concentrations of the three vessels differed by 1% (validity criterion given by OECD is met).
Applicant's summary and conclusion
- Conclusions:
- The water solubility of Fructose-1,6-Diphosphate, raw: Glucose anaerobically fermen-ted by Saccharomyces cerevisiae, concentrated, phosphorylated (CAS no. 944-754-7) was determined according to a modified TG OECD 105 design. The water solubility of the test item at 22°C was >=882 g/L. The pH of the aqueous samples was 4.
- Executive summary:
The water solubility of the test item “Fructose-1,6-Diphosphate, raw: Glucose anaerobically fermented by Saccharomyces cerevisiae, concentrated, phosphorylated“ was determined according to a modified TG OECD 105 design. To this end, increasing volumes of water were added in a stepwise procedure, to approximately 1 g of the test item at 22 ± 2 °C until complete dissolution, which occurred after addition of 0.6 mL of ultra-pure water. The concentration of test item was subsequently determined by total phosphorous analysis.
The determined water solubility of the test item is >=882 g/L at pH 4 and at 22 °C.
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