Registration Dossier
Registration Dossier
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EC number: 268-211-2 | CAS number: 68037-36-5
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- May 16, 2017 - May 19, 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- OECD 117
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - HPLC Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7570 (Partition Coefficient, n-octanol / H2O, Estimation by Liquid Chromatography)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: SCA Title 40 of the Federal Code of Regulations, Part 796, Section 1570: Partition Coefficient (n-Octanol/Water) – Estimation by Liquid Chromatography
- Deviations:
- no
- Principles of method if other than guideline:
- Partition coefficient was calculated from solubilities of the substance in water and n-octanol.
- GLP compliance:
- yes
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- < 2.98
- Temp.:
- 40 °C
- pH:
- 6.5
- Conclusions:
- Under the chromatographic conditions specified, the test substance eluted as three peaks on the ultraviolet (UV) detector. The corresponding Log POW for the test substance was a range from
- Executive summary:
Under the chromatographic conditions specified, the test substance eluted as three peaks on the ultraviolet (UV) detector. The corresponding Log POW for the test substance was a range from <thiourea to 2.98.
Reference
Table 2: Results
Sample |
Retention time (minutes) |
Mean (SD) |
Log Pow |
Mean (SD) |
Peak 1 |
||||
1 |
0.774 |
0.776 (0.0015) |
< Thiourea |
N/A (N/A) |
2 |
0.776 |
< Thiourea |
||
3 |
0.777 |
< Thiourea |
||
Peak 2 |
||||
1 |
0.957 |
0.959 (0.0015) |
0.520 |
0.539 (0.017) |
2 |
0.595 |
0.543 |
||
3 |
0.960 |
0.554 |
||
Peak 3 |
||||
1 |
1.617 |
1.611 (0.012) |
2.98 |
2.98 (0.019) |
2 |
1.598 |
2.95 |
||
3 |
1.619 |
2.99 |
||
Values less than thiourea not retained.
Description of key information
Under the chromatographic conditions specified, the test substance eluted as three peaks on the ultraviolet (UV) detector. The corresponding Log POW for the test substance was a range from <thiourea to 2.98.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 2.98
- at the temperature of:
- 40 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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