Registration Dossier
Registration Dossier
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EC number: 282-617-7 | CAS number: 84281-74-3
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data is from OECD SIDS.
Data source
Reference
- Reference Type:
- secondary source
- Title:
- SIDS Initial Assessment Profile.
- Author:
- United Nations Environmental Programme (UNEP)
- Year:
- 2 003
- Bibliographic source:
- SIDS Initial Assessment Profile, United Nations Environmental Programme (UNEP), 2003.
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- The acute Dermal toxicity test of test chemical in rat.
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- 2,2'-[(3,3'-dichloro[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[N-(2,4-dimethylphenyl)-3-oxobutyramide]
- EC Number:
- 225-822-9
- EC Name:
- 2,2'-[(3,3'-dichloro[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[N-(2,4-dimethylphenyl)-3-oxobutyramide]
- Cas Number:
- 5102-83-0
- Molecular formula:
- C36H34Cl2N6O4
- IUPAC Name:
- 2,2'-[(3,3'-dichloro[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[N-(2,4-dimethylphenyl)-3-oxobutyramide]
- Details on test material:
- Name: 2,2'-[(3,3'-dichloro[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[N-(2,4-dimethylphenyl)-3-oxobutyramide]
InChI:1S/C36H34Cl2N6O4/c1-19-7-11-29(21(3)15-19)39-35(47)33(23(5)45)43-41-31-13-9-25(17-27(31)37)26-10-14-32(28(38)18-26)42-44-34(24(6)46)36(48)40-30-12-8-20(2)16-22(30)4/h7-18,33-34H,1-6H3,(H,39,47)(H,40,48)/b43-41+,44-42+
Smiles: C([C@@H](\N=N\c1c(cc(cc1)c1cc(Cl)c(\N=N\ [C@@H](C(Nc2c(cc(cc2)C)C)=O)C(=O)C)cc1)Cl) C(=O)C)(Nc1c(cc(cc1)C)C)=O
- Name of test material (as cited in study report):Pigment Yellow 13
- Molecular formula (if other than submission substance):C36H34Cl2N6O4
- Molecular weight (if other than submission substance):685.609 g/mol
- Substance type:Organic
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- not specified
Administration / exposure
- Type of coverage:
- other: Dermal
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- not specified
- Duration of exposure:
- not specified
- Doses:
- 3000 mg/kg
- No. of animals per sex per dose:
- not specified
- Control animals:
- not specified
- Details on study design:
- not specified
- Statistics:
- not specified
Results and discussion
- Preliminary study:
- not specified
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 3 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No mortality was observed
- Mortality:
- No mortality was observed at 3000 mg/kg bw.
- Clinical signs:
- not specified
- Body weight:
- not specified
- Gross pathology:
- not specified
- Other findings:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Conclusions:
- The acute Dermal LD50 value was considered to be >3000 mg/kg bw, when rats were treated with test chemical by dermal application to the skin.
- Executive summary:
Acute Dermal toxicity study of test chemical was conducted in rats at the concentration of 3000 mg/kg bw. No mortality was observed in treated rats at 3000 mg/kg bw. Therefore, LD50 was considered to be >3000 mg/kg bw, when rats were treated with test chemical by dermal application to the skin.
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