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Diss Factsheets
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EC number: 205-785-5 | CAS number: 151-13-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Not acutely toxic
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 2000
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- not specified
- Test type:
- fixed dose procedure
- Limit test:
- yes
- Specific details on test material used for the study:
- Not specified
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- 10 total
- Control animals:
- not specified
- Details on study design:
- Not specified
- Statistics:
- Not specified
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Mortality:
- One animal died receiving this dose
- Clinical signs:
- isolated instances of diarrhea, chromorhinorrhea, ptosis, and chromodacryorrhea
- Body weight:
- Not specified
- Gross pathology:
- At necropsy, gross observations were normal for eight animals. Necropsy of the remaining two animals revealed the following changes in either one or both animals: red and/or yellow areas in the intestines, red areas in the stomach, mottled liver, mottled spleen, mottled kidneys, dark lungs, red exudate in the anogenital area, and a large amount of blood in the bladder.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The test substance was evaluated for acute oral toxicity in rats using a limit test dose of 5000 mg/kg bw. The LD50 of the test substance was greater than this dose. According to GHS criteria for acute oral toxicity, criteria for classification for acute oral toxicity are not met.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
- Quality of whole database:
- adequate
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 2000
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- not specified
- Test type:
- fixed dose procedure
- Limit test:
- yes
- Specific details on test material used for the study:
- Not specified
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- Not specified
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Details on dermal exposure:
- Not specified
- Duration of exposure:
- Not specified
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- 6 total
- Control animals:
- not specified
- Details on study design:
- Not specified
- Statistics:
- Not specified
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Mortality:
- one animal receiving this dose died
- Clinical signs:
- Isolated instances of lethargy, diarrhea, ptosis, and yellow nasal discharge, and moderate erythema (six rabbits), slight edema (one rabbit), and moderate edema (five rabbits).
- Body weight:
- Not specified
- Gross pathology:
- At necropsy, gross observations were normal for three animals. Necropsy of the remaining animals revealed the following changes: red areas in the intestines, mottled liver, white nodules in the liver, dark areas in the lungs, mottled kidneys, pale kidneys, dark spleen, and dark areas in the stomach.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The test substance was evaluated for acute dermal toxicity in rabbits using a limit test dose of 5000 mg/kg bw. The LD50 of the test substance was greater than this dose. According to GHS criteria for acute dermal toxicity, criteria for classification for acute dermal toxicity are not met.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
- Quality of whole database:
- adequate
Additional information
Justification for classification or non-classification
The LD50 values for acute lethality for analogue substances do not meet the criteria for classifcation according to Regulation EC No. 1272/2007.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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