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EC number: 265-929-8 | CAS number: 65799-47-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1993-08-12 to 1993-09-09
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.4-A (Determination of the "Ready" Biodegradability - Dissolved Organic Carbon (DOC) Die-Away Test)
- GLP compliance:
- yes
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic (adaptation not specified)
- Details on inoculum:
- - Source of inoculum/activated sludge (e.g. location, sampling depth, contamination history, procedure): primarily communal sewage treatment plant (Marl - East)
- Preparation of inoculum for exposure: washed
- Concentration of sludge: 26.8 g/l - Duration of test (contact time):
- 28 d
- Initial conc.:
- 9.51 other: mg DOC/l
- Based on:
- DOC
- Parameter followed for biodegradation estimation:
- DOC removal
- Details on study design:
- TEST CONDITIONS
- Test temperature: 21.8-22.2°C
- Continuous darkness: yes
TEST SYSTEM
- Culturing apparatus: 2000 ml Erlenmeyer flask with loose closure of aluminium foil
- Number of culture flasks/concentration: 6 flasks : 2 with test substance, two blanks, two with reference substance.
SAMPLING
- Sampling frequency: 0, 7, 14, 21, 27, 28 days
CONTROL AND BLANK SYSTEM
- Inoculum blank: yes - Reference substance:
- benzoic acid, sodium salt
- Key result
- Parameter:
- % degradation (DOC removal)
- Value:
- 37
- Sampling time:
- 28 d
- Details on results:
- Biodegradation of reference substance was >60% within a 10 day window (100% after 28 days)
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- not readily biodegradable
- Conclusions:
- Biodegradation of 37% in 28 days (EU Method C.4-A; DOC) was determined in a reliable study conducted according to an appropriate test protocol, and in compliance with GLP.
Reference
Table 1: Dissolved organic carbon levels (mg/l) and calculated % DOC reduction
Type of suspension |
0 |
7 |
14 |
21 |
27 |
28 |
||||||
DOC (mg/l) |
DOC reduction (%) |
DOC (mg/l) |
DOC reduction (%) |
DOC (mg/l) |
DOC reduction (%) |
DOC (mg/l) |
DOC reduction (%) |
DOC (mg/l) |
DOC reduction (%) |
DOC (mg/l) |
DOC reduction (%) |
|
Test sample Replicate 1 |
9.92 |
0 |
7.46 |
31 |
6.79 |
34 |
7.03 |
31 |
5.97 |
43 |
6.43 |
37 |
Test sample Replicate 2 |
10.05 |
0 |
7.52 |
31 |
6.87 |
34 |
6.75 |
35 |
6.28 |
40 |
6.55 |
37 |
Median value |
0 |
31 |
34 |
33 |
41 |
37 |
||||||
|
||||||||||||
Blank mean value |
0.48 |
- |
0.96 |
- |
0.57 |
- |
0.49 |
- |
0.55 |
- |
0.48 |
- |
Reference substance Replicate 1 |
12.05 |
0 |
0.99 |
100 |
0.77 |
98 |
0.91 |
96 |
0.70 |
99 |
0.46 |
100 |
Reference substance Replicate 2 |
10.71 |
0 |
1.04 |
99 |
0.76 |
98 |
0.45 |
100 |
0.57 |
100 |
0.51 |
100 |
Median value |
0 |
100 |
98 |
98 |
99 |
100 |
Description of key information
Biodegradation in water (screening tests): 37% in 28 days (EU Method C.4-A), read-across from an analogous substance. No significant biodegradation of the silanol hydrolysis product is expected.
Key value for chemical safety assessment
- Biodegradation in water:
- under test conditions no biodegradation observed
Additional information
There are no reliable ready biodegradation data available for [3-(2,3-epoxypropoxy)propyl]dimethoxy(methyl)silane (CAS No. 65799-47-5), therefore good quality data for the structurally-related substance, [3-(2,3-epoxypropoxy)propyl]trimethoxysilane (CAS No. 2530-83-8), have been read across. Both substances hydrolyse in the time scale of the test and have structurally similar silanol hydrolysis products, [3-(2,3-epoxypropoxy)propyl]methylsilanediol and [3-(2,3-epoxypropoxy)propyl]silanetriol respectively.
The other hydrolysis product is methanol in both cases. Methanol is readily biodegradable (OECD 2004).
[3-(2,3-Epoxypropoxy)propyl]dimethoxy(methyl)silane (CAS No. 65799-47-5) and [3-(2,3-epoxypropoxy)propyl]trimethoxysilane (CAS No. 2530-83-8) are within an analogue group of substances within which, in general, there is no evidence of any significant biodegradation once hydrolysis and subsequent biodegradation of alkoxy/acetoxy groups has been taken into account. This analogue group for the ready biodegradability endpoint consists of a number of sub-classes of substances (based on structure/functionality) with different main codes (used to represent the different sub-classes). However, read-across is carried out between substances with the same main code in most cases. The table below presents ready biodegradation data for substances within the sub-class III-12 of epoxyalkyl alkoxysilanes. [3-(2,3-epoxypropoxy)propyl]dimethoxy(methyl)silane (CAS No. 65799-47-5) and [3-(2,3-epoxypropoxy)propyl]trimethoxysilane (CAS No. 2530-83-8) are members of this sub-class.
It is therefore considered valid to read-across the results for [3-(2,3-epoxypropoxy)propyl]trimethoxysilane (CAS No. 2530-83-8) to fill the data gap for the registered substance. Additional information is given in a supporting report (PFA, 2013f) attached in Section 13.
Table: Ready biodegradation data available for substances within the relevant sub-class III-12 of chemicals
CAS |
Name |
Main code |
Readily biodegradable? Yes/no |
Result: Biodegradation after 28 day |
Guideline |
Reliability |
Corrected % biodegradation once alkoxy/acetoxy biodegradation is accounted for |
|
10217-34-2 |
Triethoxy-[2-(7-oxabicyclo[4.1.0]hept-3-yl)ethyl]silane |
III-12 |
No |
28% |
OECD 301D |
1 |
-15 |
|
2530-83-8 |
[3-(2,3-Epoxypropoxy)propyl]trimethoxysilane |
III-12 |
no |
37% |
Annex V C4-A |
1 |
4 |
|
2602-34-8 |
[3-(2,3-Epoxypropoxy)propyl]triethoxysilane |
III-12 |
no |
53% |
OECD 301F |
1 |
3 |
In the study with [3-(2,3-epoxypropoxy)propyl]trimethoxysilane (CAS No. 2530-83-8), 37% biodegradation was observed in 28 days.
[3-(2,3-Epoxypropoxy)propyl]trimethoxysilane (CAS No. 2530-83-8) hydrolyses within the timescale of the ready biodegradation study to [3-(2,3-epoxypropoxy)propyl]silanetriol and methanol. The biodegradation observed in the study is attributable to the biodegradation of the methanol hydrolysis product.
Methanol is readily biodegradable (OECD 2004).
No significant biodegradation is expected for the silanol hydrolysis product.
There is a less reliable study available for [3-(2,3-epoxypropoxy)propyl]trimethoxysilane (CAS No. 2530-83-8) (Prost, 1983) which reports a much higher biodegradation of 90% in 7 days (ISO 7827; DOC). However, the source of inoculum is not stated in the study report, and it is possible that the bacteria were acclimated to the test substance.
References:
OECD (2004). SIDS Initial Assessment Report for SIAM 19, Berlin, Germany, 18-20 October 2004, Methanol, CAS 67-56-1.
PFA (2013f). Peter Fisk Associates, Biodegradation Main Analogue Group report, PFA.300.005.007
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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