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Diss Factsheets
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EC number: 236-195-6 | CAS number: 13223-03-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- February-March, 1995
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Test material form:
- liquid
- Details on test material:
- METHACRYLOYLDIMETHYLETHYLAMMONIUMETHYLSULFATE, 39 .6% AQUEOUS FORMULATION
SUBSTANCE NUMBER: 94/521
LOT NUMBER: PARTIE 7/94
DATE OF MANUFACTURING: 10-SEP-1994
PHYSICAL STATE/APPEARANCE : LIQUID, ACHROMATIC
Constituent 1
- Specific details on test material used for the study:
- METHACRYLOYLDIMETHYLETHYLAMMONIUMETHYLSULFATE, 39 .6% AQUEOUS FORMULATION
SUBSTANCE NUMBER: 94/521
LOT NUMBER: PARTIE 7/94
DATE OF MANUFACTURING: 10-SEP-1994
PHYSICAL STATE/APPEARANCE : LIQUID, ACHROMATIC
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- ANIMAL SPECIES : RAT / WISTAR / CHBB : THOM (SPF)
ANIMAL BREEDER : DR . K . THOMAE GMBH, BIBERACH, FRG
AGE OF THE ANIMALS : YOUNG ADULT ANIMALS .
ANIMAL WEIGHTS AT START OF THE STUDY : ANIMALS OF COMPARABLE WEIGHT ; (150G - 300G) (+- 20$ OF THE MEAN WEIGHT) .
ANIMAL IDENTIFICATION : INDIVIDUAL IDENTIFICATION USING CAGE CARDS AND GROUP IDENTIFICATION BY TAIL MARKING .
ROOM TEMPERATURE/RELATIVE HUMIDITY : THE ANIMALS WERE HOUSED IN FULLY AIR-CONDITIONED ROOMS . CENTRAL AIR-CONDITIONING GUARANTEED A RANGE OF 20 - 24 DEGREES CELSIUS FOR TEMPERATURE AND OF 30 - 70 $ FOR RELATIVE HUMIDITY . THERE WERE NO DEVIATIONS FROM THESE RANGES WHICH INFLUENCED THE RESULTS OF THE STUDY .
DAY/NIGHT RHYTHM : 12 H/12 H(6 .00 A .M . - 6 .00 P .M / 6 .00 P .M . - 6 .00 A .M . )
TYPE OF CAGE : STAINLESS STEEL WIRE MESH CAGES, TYPE DK-III (BECKER 6 CO ., CASTROP-RAUXEL, FRG )
NO . OF ANIMALS PER CAGE : SINGLE HOUSING .
BEDDING : NO BEDDING IN THE CAGES ; SAWDUST IN THE WASTE TRAYS .
DRINKING WATER : TAP WATER AD LIBITUM PER DAY .
DIET : KLIBA-LABORDIAET 343, KLINGENTALMUEHLE AG, KAISERAUGST, SWITZERLAND ,
AD LIBITUM .
ANALYSIS OF DRINKING WATER : THE DRINKING WATER IS REGULARLY ASSAYED FOR CHEMICAL CONTAMINANTS BY THE MUNICIPAL AUTHORITIES OF FRANKENTHAL AND THE TECHNICAL SERVICES OF BASF AKTIENGESELLSCHAFT AS WELL AS FOR THE PRESENCE OF GERMS BY A CONTRACT LABORATORY .
ANALYSIS OF FEED : THE FEED USED IN THE STUDY WAS ASSAYED FOR CHEMICAL AND MICROBIOLOGICAL CONTAMINANTS .
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- SINGLE ORAL ADMINISTRATION BY GAVAGE .
- Doses:
- 2 dose level groups: Dose levels 200 and 2000 mg/kg b.w.
Administration volume 10 mL/kg b.w. - No. of animals per sex per dose:
- Number of animals = 3 males and/or 3 females
- Control animals:
- no
- Details on study design:
- THE ANIMALS WERE GIVEN NO FEED AT LEAST 16 HOURS BEFORE ADMINISTRATION, BUT WATER WAS AVAILABLE AD LIBITUM .
TIME OF DAY OF ADMINISTRATION : IN THE MORNING .
OBSERVATION PERIOD : 14 DAYS
BODY WEIGHT DETERMINATION : INDIVIDUAL BODY WEIGHTS SHORTLY BEFORE APPLICATION (DAY 0), WEEKLY THEREAFTER AND AT THE END OF THE STUDY (BEFORE FASTING PERIOD) .
SIGNS AND SYMPTOMS : RECORDING OF SIGNS AND SYMPTOMS SEVERAL TIMES ON THE DAY OF ADMINISTRATION, AT LEAST ONCE EACH WORKDAY FOR THE INDIVIDUAL ANIMALS ; THESE RECORDS ARE MAINTAINED WITH THE RAW DATA.
GENERAL OBSERVATIONS AND A CHECK WAS MADE TWICE EACH WORKDAY AND ONCE ON MORTALITY : SATURDAYS, SUNDAYS AND ON PUBLIC HOLIDAYS FOR GENERAL OBSERVATIONS AND FOR ANY DEAD OR MORIBUND ANIMALS
PATHOLOGY : NECROPSY AT THE LAST DAY OF THE OBSERVATION PERIOD. WITHDRAWAL OF FOOD AT LEAST 16 HOURS BEFORE KILLING WITH C02 ; THEN NECROPSY WITH GROSSPATHOLOGY EXAMINATION . NECROPSY OF ALL ANIMALS THAT DIED BEFORE AS EARLY AS POSSIBLE . - Statistics:
- No statistical analysis was performed (the method used is not intended to allow a calculation of a precise LD50 value).
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- 2 000 mg/kg bw
- Based on:
- test mat.
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality
- Clinical signs:
- other: No clinical signs
- Gross pathology:
- No signs of abnormalities were noted at necropsy at any dose level.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Under the conditions of this study, the range of mortality of the test substance after oral application was found to be greater than 2000 mg/kg body weight for male and female animals. The LD0 was 2000 mg/kg and the LD 50 was greater than 2000 mg/kg.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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