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Diss Factsheets
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EC number: 250-195-3 | CAS number: 30431-54-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 999
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: guidelines for microbial mutagenicity testing as set forth by various international regulatory authorities (e.g., OECD, 1981; US EPA, 1982; US FDA, 1993).
- Version / remarks:
- this testing protocol complies fully with (or exceeds) proposed revised testing guidelines developed by the Organisation for Economic Co-operation and Development (Gatehouse, et al., 1994) and the International Conference on Harmonisation (ICH, 1995, 1997).
- GLP compliance:
- yes
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Bis(2,4,5-trichloro-6-carbopentoxyphenyl) oxalate
- EC Number:
- 250-195-3
- EC Name:
- Bis(2,4,5-trichloro-6-carbopentoxyphenyl) oxalate
- Cas Number:
- 30431-54-0
- Molecular formula:
- C26H24Cl6O8
- IUPAC Name:
- pentyl 2,3,5-trichloro-6-[(2-oxo-2-{3,4,6-trichloro-2-[(pentyloxy)carbonyl]phenoxy}acetyl)oxy]benzoate
- Reference substance name:
- Butyl benzoate
- EC Number:
- 205-252-7
- EC Name:
- Butyl benzoate
- Cas Number:
- 136-60-7
- Molecular formula:
- C11H14O2
- IUPAC Name:
- butyl benzoate
- Test material form:
- liquid
Constituent 1
Constituent 2
Method
Species / strainopen allclose all
- Species / strain / cell type:
- S. typhimurium TA 1535, TA 1537, TA 98, TA 100 and TA 102
- Species / strain / cell type:
- E. coli WP2 uvr A
- Metabolic activation:
- with and without
- Metabolic activation system:
- S9
- Test concentrations with justification for top dose:
- at doses of 5.00, 16.7, 50.0, 167, 500 and 1670 nl/plate under plate incorporation treatment conditions, and at doses of 1.67, 5.00, 16.7, 50.0, 167 and 500 nl/plate under liquid pre-incubation treatment conditions
- Vehicle / solvent:
- DMSO
Controls
- Negative solvent / vehicle controls:
- yes
- Positive controls:
- yes
- Positive control substance:
- 9-aminoacridine
- 2-nitrofluorene
- sodium azide
- mitomycin C
- other: ENNG for WP2 uvrA, without S9; 2-Aminofluorene for TA102, with S9, 2-anthramine for others with S9
Results and discussion
Test results
- Key result
- Species / strain:
- other: S. typhimurium tester strains (TAI535, TA1537, TA98, TAIOO and TA 102), and in E. coli strain WP2 uvrA
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- other: Inhibited growth or complete toxicity again was observed in all six tester strains at the highest 1-4 doses evaluated under both treatment conditions with and without S9.
- Vehicle controls validity:
- not applicable
- Untreated negative controls validity:
- not applicable
- True negative controls validity:
- valid
- Positive controls validity:
- valid
Applicant's summary and conclusion
- Conclusions:
- The test item is considered to be negative in the Ames/Salmonella-E. coli Reverse Mutation Assay, under the conditions, and according to the criteria, of the test protocol.
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