Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 947-945-3 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation
- Remarks:
- in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- Unexpected anaphylaxis to cashew nut
- Author:
- O. Quercia*, S. Rafanelli, L. Marsigli, F. G. Foschi, G. F. Stefanini
- Year:
- 1 999
- Bibliographic source:
- Allergy 54,892-902
Materials and methods
- Principles of method if other than guideline:
- Allergy to the cashew nut in human case report.
- GLP compliance:
- not specified
- Type of study:
- other: anaphylaxis to cashew nut
Test material
- Reference substance name:
- 8007-24-7
- Cas Number:
- 8007-24-7
- IUPAC Name:
- 8007-24-7
- Details on test material:
- - Name of test material (as cited in study report):Cashew nut
Constituent 1
In vivo test system
Test animals
- Species:
- human
- Sex:
- male
- Details on test animals and environmental conditions:
- Not available
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- other: not applicable
- Vehicle:
- no data
- Concentration / amount:
- Not available
Challengeopen allclose all
- Route:
- other: not applicable
- Vehicle:
- no data
- Concentration / amount:
- Not available
- No. of animals per dose:
- Not applicable
Results and discussion
Any other information on results incl. tables
A patient allergic to pistachio who had anaphylaxis due to cashew nuts. A 42- year-old white man was admitted to our emergency room complaining of mouth and lip itching, slurred voice, dyspnea, and vomiting a few minutes after eating some cashew nuts. Prompt treatment with steroids, antihistamines, and epinephrine relieved the patient's symptoms, leading to a complete recovery in about 24 h.
Three years later, the patient complained of the same symptoms while eating pasta with a sauce based on garlic, basil, and pine nuts and attributed the symptoms to pine nuts and basil. After a few months, mouth itching and vomiting occurred again when the patient ate pistachio nuts.
To diagnose an adverse reaction to Anacardiaceae, a skin prick by prick test was performed with a positive result for pistachio and cashew nut.
Applicant's summary and conclusion
- Interpretation of results:
- sensitising
- Remarks:
- Migrated informationCriteria used for interpretation of results: EU
- Conclusions:
- Based on the allergic reactions developed by human due to intake of pistacio and cashew nuts (cashew nut shell liquid being the extract of cashew nut)belonging to the family Anacardiaceae it is concluded that cashew nut shell liquid is a skin sensitiser.
- Executive summary:
As illustrated in the case report a patient allergic to pistachio who had anaphylaxis due to cashew nuts reported mouth and lip itching, slurred voice, dyspnea, and vomiting.Three years later, the patient complained of the same symptoms while eating similar products belonging to the family Anacardiaceae. Based on the allergic reactions developed by human due to intake of pistacio and cashew nuts (cashew nut shell liquid being the extract of cashew nut)belonging to the family Anacardiaceae it is concluded that cashew nut shell liquid is a skin sensitiser.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.