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EC number: 226-827-9 | CAS number: 5495-84-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 23 October 1998 to 11 November 1998
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 998
- Report date:
- 1998
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- 2-isopropyl-9H-thioxanthen-9-one
- EC Number:
- 226-827-9
- EC Name:
- 2-isopropyl-9H-thioxanthen-9-one
- Cas Number:
- 5495-84-1
- Molecular formula:
- C16H14OS
- IUPAC Name:
- 2-isopropyl-9H-thioxanthen-9-one
- Test material form:
- solid: particulate/powder
- Details on test material:
- - Appearance: yellow powder
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Crl:Han Wist(Glx:BRL)BR
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Females nulliparous and non-pregnant: Yes
- Age at study initiation: Five to seven weeks old
- Weight at study initiation: 113 to 128 g (males) and 107 to 126 g (females)
- Fasting period before study: Overnight fasting prior to dosing which continued until approximately three hours after dosing
- Housing: Up to five rats of the same sex were accommodated in suspended stainless steel mesh cages (with minimum internal dimensions of 55 x 34 x 20 cm). The cages were suspended over cardboard lined trays for collection of excreta. The liners were replaced at least twice weekly.
- Diet: Ad libitum
- Water: Ad libitum
- Acclimation period: 8 days
ENVIRONMENTAL CONDITIONS
- Temperature: 19 to 25 °C
- Humidity: 40 to 80 % RH
- Air changes: At least 14 air changes per hour
- Photoperiod: The rooms were illuminated by fluorescent strip-lights for twelve hours daily.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- methylcellulose
- Details on oral exposure:
- VEHICLE
- Amount of vehicle: 20 mL/kg
- Lot/batch no.: T71685
- Purity: 1 % Methyl cellulose
MAXIMUM DOSE VOLUME APPLIED: 20 mL/kg - Doses:
- 2 000 mg/kg
- No. of animals per sex per dose:
- Preliminary study: Two females at 2 000 mg/kg
Main study: Five animals per sex at 2 000 mg/kg. - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Clinical signs: Treated rats were observed closely for clinical signs of reaction to treatment. Clinical signs were recorded frequently on Day 1 and regularly for the remainder of the study, (the minimum schedule being at least once within half an hour of dosing and four times within the first four hours following administration, twice daily on Days 2, 3 and 4 and once daily from the fifth to last day of the observation period). Individual records of clinical signs were maintained for each treated rat.
- Body weights: Rats were weighed on Day -1 ( day before dosing), on Day 1 and Day 8 and on Day 15 of the main study.
- All rats were killed by intraperitoneal injection of sodium pentobarbitone on Day 15. After exsanguination a full macroscopic necropsy was performed and any lesions recorded. The necropsy procedure included inspection of external surfaces and orifices, all viscera and tissue within the abdominal, thoracic and cranial cavities, free-hand sectioning of the liver and kidneys and examination of representative sections of mucosa} surfaces of the stomach, small and large intestines.
Results and discussion
- Preliminary study:
- A preliminary group of two female fasted rats was subjected to a single oral dose of the test material at 2000 mg/kg. There was no death and no overt clinical signs following treatment. Necropsy on Day 8 revealed no macroscopic changes.
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No animal died following a single oral administration of the test material at 2 000 mg/kg.
- Clinical signs:
- other: No clinical signs of reaction to treatment were seen during the observation period.
- Gross pathology:
- No macroscopic changes were observed at necropsy on Day 15.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Under the conditions of this study, the oral LD0 value was established to exceed 2 000 mg/kg body weight.
- Executive summary:
The acute oral toxicity of the test material was investigated in accordance with the standardised guidelines OECD 401 and EU Method B1 under GLP conditions.
The test material was formulated in 1 % methyl cellulose at the limit dose of 2 000 mg/kg. The test formulation was kept stirring during dosing.
A preliminary group of two female fasted rats was subjected to a single oral dose of the test material at 2 000 mg/kg. There was no death and no overt clinical signs following treatment. Necropsy on Day 8 revealed no macroscopic changes. Five male and five females were then subjected to the same limit dose and observed for a period of 14 days.
No animal died following a single oral administration of the test material at 2 000 mg/kg. No clinical signs of reaction to treatment were seen during the observation period. All rats gained weight during the first and second weeks of the observation period and no macroscopic changes were observed at necropsy on Day 15.
Under the conditions of this study, the oral LD0 value was established to exceed 2 000 mg/kg body weight.
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