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EC number: 280-479-2 | CAS number: 83547-95-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1993
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods
- Qualifier:
- according to guideline
- Guideline:
- other: 87/302/EEC page 89-94 Algal Inhibition test
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- TEST MATERIAL (as stated in study report): TK 12184; trade name D 16-051
SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: Sponsor / Batch No. 0870413, within specifications
- Expiration date of the lot/batch: 07/1996
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: room temperature - Analytical monitoring:
- yes
- Details on sampling:
- Sampling for analysis: Composite samples of each test concentration were drawn by mixing Identical volumes of the test Solutions taken from the approximate center of the test vessels. They were taken immediately before exposure and after 72 hours exposure and kept at - 18 deg C to - 22 deg C until analysis.
- Vehicle:
- no
- Details on test solutions:
- Stock solution: 50.3 mg test substance were mixed and made up to 500 ml with water. 100 ml of this blend were mixed and made up to 1000 ml with water (dilution 1:10). Calculated amounts of the stock solution to produce the desired test concentrations were given into the water and were homogeneously distributed.
- Test organisms (species):
- other: Scenedesmus subspicatus
- Details on test organisms:
- TEST ORGANISM
- Source (laboratory, culture collection): Collection of algae cultures, Pflanzenphysiologisches Institut, University, Nikolausberger Weg 18, D-3400 Göttingen, Germany
ACCLIMATION
- Acclimation period: 3 days under test conditions - Test type:
- static
- Water media type:
- not specified
- Limit test:
- no
- Remarks on exposure duration:
- 72 hours
- Test temperature:
- 23 ± 1 deg C
- Nominal and measured concentrations:
- Nominal : 0.123, 0.37, 1.1, 3.3 and 10 mg test substance / L
Actual (end of exposure): 0.1, 0.1, 0.1, 1.1 and 5.3 mg test substance / L - Details on test conditions:
- Each test concentration was tested in 3 replicates, the blank control in 6.
- Reference substance (positive control):
- no
- Duration:
- 72 h
- Dose descriptor:
- other: EbC50 (0-72 h)
- Effect conc.:
- 3.1 mg/L
- Conc. based on:
- test mat.
- Basis for effect:
- biomass
- Remarks on result:
- other: Value based on actual end concentrations
- Remarks:
- 95% confidence limit: 2.2 - 3.9 mg/L
- Duration:
- 72 h
- Dose descriptor:
- other: NOEbC (0 - 72 h) (5% level)
- Effect conc.:
- 0.1 mg/L
- Conc. based on:
- test mat.
- Basis for effect:
- biomass
- Remarks on result:
- other: Value based on actual end concentration
- Reported statistics and error estimates:
- The EbC-50 values were calculated according to the maximun likellhood method, logit model (Mc Cullagh, P., Neider, J.A., 1983: Generalized linear models, Chapman & Hall, London)
- Validity criteria fulfilled:
- yes
- Conclusions:
- In a guideline algal growth inhibition study of TK 12 184, the EbC50 (0 - 72 h) was 3.1 mg/L (95% confidence limits: 2.2 - 3.9 mg/L). The NOEbC was 0.1 mg/L.
Values were based on actual end of exposure concentrations. - Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- (Q)SAR
- Adequacy of study:
- supporting study
- Study period:
- 2018
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Principles of method if other than guideline:
- Results predicted by US EPA ECOSAR v1.11 model.
- GLP compliance:
- no
- Details on results:
- No effects are expected at saturated concentrations in water. The estimated logKow for this substance is greater than the class specific cut-offs for green algae toxicity, and the predicted effect level exceeds the water solubility of this substance by more than 10x.
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- The US EPA ECOSAR v1.11 model predicts no effects at saturated concentrations in water for TGEPO (CAS No. 83547-95-9). The estimated logKow for this substance is greater than the class specific cut-offs for green algae toxicity, and the predicted effect level exceeds the estimated water solubility of this substance by more than 10x.
Referenceopen allclose all
Description of key information
In an algal growth inhibition study of TK 12 184, the EbC50 (0 - 72 h) was 3.1 mg/L (95% confidence limits: 2.2 - 3.9 mg/L). The NOEbC was 0.1 mg/L. Values were based on actual end of exposure concentrations.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 3.1 mg/L
Additional information
The US EPA ECOSAR v1.11 model predicts no effects at saturated concentrations in water for TGEPO (CAS No. 83547-95-9). The estimated logKow for this substance is greater than the class specific cut-offs for green algae toxicity, and the predicted effect level exceeds the estimated water solubility of this substance by more than 10x.
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