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Reaction mass of Phosphonium, (4-ethoxy-3-methyl-4-oxo-2-butenyl)triphenyl bromide [4-Ethoxy-3-methyl-4-oxo-2-butenyl]-triphenylphosphonium bromide and Phosphonium, (4-ethoxy-3-methyl-4-oxo-2-butenyl)triphenyl chloride [4-Ethoxy-3-methyl-4-oxo-2-butenyl]-triphenylphosphonium chloride[4-Ethoxy-3-methyl-4-oxobut-2-en-1-yl](triphenyl[4-Ethoxy-3-methyl-4-oxobut-2-en-1-yl](triphenyl)phosphonium bromide
EC number: 900-131-1 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1993
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Well documented study according to GLP guidelines. No indication if OECD guideline was used, only 4 strains were employed
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Report date:
- 1993
Materials and methods
Test guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- Deviations:
- yes
- Remarks:
- only 4 strains were employed
- Principles of method if other than guideline:
- -
- GLP compliance:
- yes (incl. QA statement)
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Reaction mass of [(4-Ethoxy-3-methyl-4-oxobut-2-en-1-yl](triphenyl)-phosphonium bromide and [(4-Ethoxy-3-methyl-4-oxobut-2-en-1-yl](triphenyl)-phosphonium chloride
- IUPAC Name:
- Reaction mass of [(4-Ethoxy-3-methyl-4-oxobut-2-en-1-yl](triphenyl)-phosphonium bromide and [(4-Ethoxy-3-methyl-4-oxobut-2-en-1-yl](triphenyl)-phosphonium chloride
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- S. typhimurium, other: TA97, TA98, TA100 and TA102
- Additional strain / cell type characteristics:
- other: rfa, delta-uvrB, pKM101, pAQ1
- Metabolic activation:
- with and without
- Metabolic activation system:
- S9
- Test concentrations with justification for top dose:
- 0, 50, 166, 500, 1666, 5000 ug/plate
Controls
- Untreated negative controls:
- yes
- Negative solvent / vehicle controls:
- yes
- True negative controls:
- yes
- Positive controls:
- yes
- Positive control substance:
- 2-nitrofluorene
- sodium azide
- mitomycin C
- other: ICR 191, 2- Aminoanthracene
Results and discussion
Test results
- Species / strain:
- S. typhimurium, other: TA97, TA98, TA100 and TA102
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- valid
- Positive controls validity:
- valid
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Any other information on results incl. tables
-
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative
neither Wittigesterhalogenid per se, nor any of the metabolites formed under the described experimental conditions is
mutagenic in the Ames tester strains TA97, TA98, TA100 and TA102. - Executive summary:
A standard as well as a preincubation modification assay in absence and in presence of a exogenous metabolic
activation system (S9 mix) were perfomed. The four plasmid bearing tester strains TA97, TA98, TA100 and TA102 were employed. Responsiveness of the strains and activity of the S9 mix were demonstrated by including recommended positive controls in parallel to each experiment.
Wittigesterhalogenid was dissolved in dimethylsulfoxide (DMSO). The dose range 50 to 5’000 ug/plate, the generally recommended highest test concentration for non toxic compounds was evaluated. No precipitation of the compound was observed up to the chosen maximum test concentration. Toxic effects were only obtained in the preincubation modification assay starting at 500 ug/plate (TA102;-S9).
No toxic effects were observed in the standard plate incorporation assay. Wittigesterhaolgenid did not induce an incease in the number of revertant colonies.
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