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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1989
Report date:
1989

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
yes
Test type:
standard acute method

Test material

Constituent 1
Chemical structure
Reference substance name:
Nonafluoro(trifluoromethyl)cyclopentane
EC Number:
217-298-5
EC Name:
Nonafluoro(trifluoromethyl)cyclopentane
Cas Number:
1805-22-7
Molecular formula:
C6F12
IUPAC Name:
1,1,2,2,3,3,4,4,5-Nonafluoro-5-(trifluoromethyl)cyclopentane
Test material form:
solid - liquid: suspension
Details on test material:
Test materual suspended in arachis oil

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female
Details on test animals or test system and environmental conditions:
Males weighed 120-155g, females weighed 132-155g and were approx 5-8 weeks old.

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
arachis oil
Doses:
5000mg/kg bodyweight
No. of animals per sex per dose:
5
Control animals:
no

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
discriminating dose
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
Mortality:
None
Clinical signs:
No evidence of systemic toxicity was notice.
Body weight:
All animals showed expected gain in bodyweight during the study period.

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Remarks:
Migrated information Criteria used for interpretation of results: other: EEC directive 84/449/EEC
Conclusions:
Acute oral median lethal dose (LD50) of the test material in the Sprague Dawley strain rat is greater than 5000mg/kg bodyweight.