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Diss Factsheets
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EC number: 701-168-4 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Between 04 February 1981 and 25 February 1981
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study conducted in compliance with agreed protocols, with limited reporting and no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not affect the quality of the relevant results.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: Section 772 .112-21 CFR 40
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- 61789-86-4
- IUPAC Name:
- 61789-86-4
- Reference substance name:
- Sulfonic acids, petroleum, calcium salts
- EC Number:
- 263-093-9
- EC Name:
- Sulfonic acids, petroleum, calcium salts
- IUPAC Name:
- 263-093-9
- Details on test material:
- Identification: OS#47860
Date received: 28 January 1981
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- other: Sherman-Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- Five groups of five male albino rats of the Sherman-Wistar strain weighing between 200 and 300 gm were employed in this study.
The rats were deprived of food but not water overnight prior to dosing.
The animals were housed and maintained in compliance with the Animal Welfare Act, (Pub. L-94-279) 9 CFR Part 3.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- Each animal was weighed and dosed by direct administration of the experimental material into the stomach by means of a syringe and dosing needle.
The sample was dosed as supplied and warmed slightly. - Doses:
- The following dosage levels were administered
1.0 gm/kg
2.0 gm/kg.
4.0 gm/kg
8.0 gm/kg,
16.0 mg/kg. - No. of animals per sex per dose:
- 5 animals per dose, 5 dose groups
- Control animals:
- no
- Details on study design:
- Five groups of five male albino rats of the Sherman-Wistar Stain weighing between 200 and 300 gm were employed in this study.
The rats were deprived of food but not water overnight prior to dosing.
Each animal was weighed and dosed by direct administration of the experimental material into the stomach by means of a syringe and dosing needle.
The sample was dosed as supplied and warmed slightly.
The following dosage levels were administered
1.0 gm/kg
2.0 gm/kg.
4.0 gm/kg
8.0 gm/kg,
16.0 mg/kg.
Following administration the animals were allowed food and water ad libitum for the 14 day observation period during which time the rats were observed for signs of toxicity and mortalities. - Statistics:
- None recorded.
Results and discussion
Effect levels
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 16 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 95% CL not reported
- Mortality:
- Two animals died at the 16.0 mg/kg dose level
No mortalites observed at any other dose level
Individual mortality data are given in Table 1 - attachment 1 - Clinical signs:
- other: 8.0 gm/kg - Within 2 hours the animals were ruffled and slightly depressed. They appeared essentially normal after 24 hours. 16.0 gm/kg - Within 2 hours the animals were ruffled, dirty and depressed. They remained in generally poor health through the firs
- Gross pathology:
- 16.0 mg/kg - Gross pathologic examination revealed nothing remarkable.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The subject material when studied in male albino rats has an acute oral LD50 greater than 16.0 gm/kg.
- Executive summary:
To study the acute oral toxicity in rats of the subject material.
Five groups of five male albino rats of the Sherman-Wistar Strain weighing between 200 and 300 gm were employed in this study.
The following dosage levels were administered
1.0 gm/kg
2.0 gm/kg
4.0 gm/kg
8.0 gm/kg
16.0 gm/kg.
Acute Oral Toxicity LD50 Study - the LD50 is greater than 16.0 gm/kg
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