Registration Dossier
Registration Dossier
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EC number: 268-453-9 | CAS number: 68092-29-5
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because exposure of humans via inhalation is not likely taking into account the vapour pressure of the substance and/or the possibility of exposure to aerosols, particles or droplets of an inhalable size
- Justification for type of information:
- JUSTIFICATION FOR DATA WAIVING
Waived based on a low vapour pressure of 0.0005 Pa at 25°C. In accordance with Annex VIII of Regulation (EC) 1907/2006 (REACH), section 8.5.2 it is considered justified to omit the acute toxicity by inhalation as testing by this route is inappropriate. Exposure via the inhalation route is not relevant due to the substance being a liquid with a very low vapour pressure. Such liquids require strong measures to be taken to generate airborne particulates of sufficiently high respirability. Consequently the acute oral and acute dermal studies are more applicable to the evaluataion of acute toxicity and relavence to human exposure. In addition, a supporting publication by Knaak et al (1997) "Toxicology of Mono-, Di-, and Triethanolamine" documented an acute inhalation study with triethanolamine in which the low vapour pressure limited the technically highest attainable concentration to ca. 1.8 mg/m3 (0.29 ppm).
Data source
Materials and methods
Results and discussion
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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