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Diss Factsheets
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EC number: 208-816-0 | CAS number: 542-52-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 201 (Freshwater Alga and Cyanobacteria, Growth Inhibition Test)
- Version / remarks:
- 2011
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Dibutyl carbonate
- EC Number:
- 208-816-0
- EC Name:
- Dibutyl carbonate
- Cas Number:
- 542-52-9
- Molecular formula:
- C9H18O3
- IUPAC Name:
- dibutyl carbonate
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- Analytical evaluation of the test concentrations of Dibutyl
carbonate and the control was carried out from freshly prepared
media after 0 hours (with algae) and old test media after 72 hours
(with algae). Separate replicates for each test item concentration
and control for the test item analysis at the beginning of the exposure
were prepared with algae. The samples for the test item analysis
after 72 hours were prepared with algae and incubated under test
conditions. Samples were delivered in the original test vessels (59
mL, without headspace). The analyses were performed on the same
day. One additional retain sample was taken for each test
concentration on each occasion in the same way and stored at room
temperature for an additional analysis in case of inconclusive
results. In this study the retain samples of the test concentration
100 mg/L were analysed additionally after a maximum storage
period of three days.
Test solutions
- Vehicle:
- no
- Details on test solutions:
- Five stock solutions with a dilution factor of '110 (1.00 - 3.16-
10.0 -31.6 - 100 mg/L) were freshly prepared by pipetting the
test item to the dilution water (see Table 2). The density was
taken into account.
The stock solutions were stirred for 15 minutes at 1100 rpm,
room temperature. After this, the solution were left to stand for 30
minutes and were carefully checked for turbidity or a surface
layer. At all concentration levels no turbidity or surface layer was
observed.
Test organisms
- Test organisms (species):
- Raphidocelis subcapitata (previous names: Pseudokirchneriella subcapitata, Selenastrum capricornutum)
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 72 h
Test conditions
- Hardness:
- 26.7 CaCO3 mg/L
- Test temperature:
- 22-23°C
- pH:
- 8.0-9.3
- Salinity:
- 0.8 mmol/L
- Conductivity:
- 180 pS/cm
- Nominal and measured concentrations:
- The measured concentrations of item Dibutyl carbonate at the start of the exposure (0 h) were in
the range of 58 to 102% of the nominal concentrations without a concentration-related tendency.
At the end of the exposure (72 h), the measured concentrations of item Dibutyl carbonate were
in the range of 63 to 83% of the nominal concentrations and in the range of 80 - 133% of the
initial measured concentration. Since not all measured test item concentrations were within ± 20%
of the nominal concentrations, the contents of item Dibutyl carbonate were evaluated as
geometric mean measured concentrations. - Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate
Results and discussion
Effect concentrationsopen allclose all
- Key result
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- 10.2 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Remarks on result:
- other: 95% CL 9.43 - 11.7
- Key result
- Duration:
- 72 h
- Dose descriptor:
- EC10
- Effect conc.:
- 5.43 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Remarks on result:
- other: 94% CL 4.12 -6.70
- Details on results:
- It cannot be excluded that the effects were partly caused by undissolved test item.
- Results with reference substance (positive control):
- ErC50 = 0.559 mg/L
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
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